Researchers wear protective gear at the Wuhan Institute of Virology. Photo: Xinhua US President Joe Biden announced last week that the US intelligence community had questioned two possible origins of the COVID-19 pandemic: “Human contact with infected animals or a laboratory incident. “. He ordered a new investigation “to bring us closer to a final conclusion”. According to Bloomberg, no matter where the investigation leads, the history of laboratory safety shows that leakage of pathogens has happened, sometimes with deadly consequences. Smallpox virus leak By the late 1970s, smallpox had been eradicated from the wild, but research on the disease continues in several laboratories around the world, including one in Birmingham (UK). where a virulent strain of smallpox virus is handled. In the summer of 1978, a medical photographer working there named Janet Parker became ill. When pustules spread on her body, the local doctor diagnosed it as a severe case of smallpox. Victim Janet Parker in the smallpox virus leak from the laboratory. It was the third leak of the smallpox virus in that decade from a UK laboratory. The British government has drastically stopped the outbreak by urgently isolating hundreds of people and vaccinating many others. Thanks to those efforts, only one other person became infected, and that was Parker’s mother. However, the female photographer experienced a painful, lonely death in quarantine, and is believed to be the last known fatal victim of smallpox. But there are other victims of the incident. At that time the press mentioned the director of the laboratory in Birmingham, a smallpox virus expert named Henry Bedson. Although there was no evidence, the media still blamed him for the incident. Quarantined at home and in despair, Bedson slit his own throat and died shortly thereafter. The British government has organized a thorough investigation into the outbreak. An investigation found Mr Bedson may not have followed adequate safety procedures and speculated that Parker contracted smallpox from a virus that leaked into the gas pipeline. Technicians at a laboratory in Rockville, Maryland (USA), where smallpox vaccine is produced. A lawsuit later dismissed this explanation, and raised the disturbing possibility that Parker herself had entered one of the workspaces without proper protection. To this day, the debate over the Parker incident remains unresolved. Anthrax spores from the lab When laboratories let pathogens leak in a secret environment, it is much harder to confirm the source of the outbreak. A case in point is the anthrax outbreak in Sverdlovsk, a rather isolated city in the former Soviet Union. In 1979, rumors of anthrax killing dozens, even thousands, began to spread to the West. Later that year, Soviet newspapers confirmed some reports, noting that more than 100 people had contracted anthrax after eating contaminated meat, and over 60 had died. It was a tragedy, but perhaps unavoidable because anthrax is readily apparent in local animal populations. However, US intelligence officials are not convinced by that. Satellite images show disinfecting truck-like objects around the city, with a significant focus of activity on a mysterious military facility known as Complex 19. CIA analysts have reported hypothesized that the Soviet Union leaked a weaponized form of anthrax. The Soviets reacted indignantly to this allegation. In 1980, Russia’s official news agency Itar Tass published a rebuttal titled “A Seed of Deception,” accusing the US of making false statements to gain geopolitical advantage. Sverdlovsk was once one of the military secret cities of the Soviet era. Then, under the administration of President Ronald Reagan, the CIA sought to better handle what happened. They asked Matthew Meselson, a distinguished geneticist at Harvard who worked on the bioweapons ban program, to directly assess the evidence. Mr. Meselson was not convinced by the US intelligence findings. In the 1980s, he rejected another theory that the Soviet Union used some kind of fungal weapon in Laos – and he initially held the same view on the anthrax case, endorsing the main explanation. information from the Soviet Union, with one important caveat: Without a thorough investigation in Sverdlovsk, it would be impossible to know for certain what happened. Essentially, Mr. Meselson supported the explanation that the meat was tainted, judging it to be “completely reasonable and consistent” based on what was known about anthrax. He also arranged meetings with Soviet scientists to add credence to this interpretation, with slides of pathology samples taken from the victims. The US intelligence community, however, remains skeptical. And in this case, the intelligence agencies, not the scientists, turned out to be right. After the breakup of the Soviet Union, Meselson and other researchers finally had access to pathological samples taken from the victims’ lungs, which showed they had died from inhaling anthrax spores. Subsequent revelations added to the picture of what happened. Turns out Complex 19 is a biological weapons facility. Here they produce anthrax spores. According to the Laboratory Director of Complex 19 at the time, a filter connected to the spore dryer was clogged. This still happens often. The military officer in charge left a message for his replacement on the next shift but did not enter the logbook as is customary. When it came to the next shift, the replacement team looked at the notebook, saw nothing, and restarted the purifier. A series of anthrax spores quickly spread throughout the vicinity. Mr. Meselson eventually pieced together all the data and published a paper in the journal Science, which combined wind data with interviews, pathological samples and other evidence to describe the outbreak. Coal killed more than 60 people. That was in 1994, 15 years after the incident. Mysterious flu virus leak In addition, there is another incident that took place in the Soviet Union that is still a mystery. In the same decade that witnessed the leaks of smallpox in Britain and anthrax in the Soviet Union, there was also an unusual strain of flu at the time, called H1N1. Laboratory virus leaks have had deadly consequences. Photo: Atlantis In 1977, an H1N1 outbreak broke out on the border between China and the Soviet Union. The epidemic eventually spread worldwide that year, causing an unusual proportion of young patients. The mortality rate from epidemics is relatively low compared to some strains of influenza. But that’s not the problem. The worrying aspect of the epidemic is that this particular strain of H1N1 has not been present since 1950, when it was superseded by other strains of influenza. The appearance of that kind of “back in time” was confusing. Some researchers speculate that the virus may have “escaped” from a laboratory in the Soviet Union or China, but both countries deny this theory. However, the matter remains a puzzle for virologists. Many theories have been born and come to explain the so-called “frozen evolution”, among which the most prominent is the hypothesis that the virus spread to humans from a laboratory, possibly testing a vaccine to neutralize the disease. swine flu. A scientist involved in the development of a vaccine. Photo: Reuters The exact origin of COVID-19 may not be known All of the above incidents occurred in the 1970s. Laboratory safety was expected to have improved since then, but that has not always been the case. After the SARS outbreak in 2003, laboratories around the world began studying the virus. Since that time, there have been no less than 6 laboratory leaks of SARS. The first occurred at the National University of Singapore, where a student contracted the virus from a sample of the virus. This was followed by an incident in Taiwan/China, where a researcher contracted the virus, possibly during the disinfection of waste products from the laboratory. After that, several leaks happened at the National Institute of Virology of China. In one incident, a researcher infected her mother with the virus, and she died of SARS. In all cases, human negligence, mainly exacerbated by inadequate safety protocols, was the cause of the pathogen leakage. History has supported the theories being put forward that the current COVID-19 pandemic may not have a natural origin, but we are not in a position to rush into judgment. When it comes to lab leaks, the investigation and review process often takes a long time, and sometimes the answers remain unsatisfactory and incomplete. In the case of the COVID pandemic, we must prepare for the possibility that the world may never know the exact origins of a pandemic that has claimed millions of lives.

The root cause is believed to be 30 years of not trying to clear people’s doubts about vaccine side effects, according to the above article. Nikkei Asia 10/5. The landmark court ruling of 1992 During the 1980s, Japan possessed world-leading vaccine technology for the treatment of chickenpox, encephalitis, and pertussis. These technologies are licensed to the US and other countries. But vaccine development in Japan came to a near complete halt following a 1992 court ruling ordering the government to compensate people for side effects after vaccination. The Japanese people see this as a landmark ruling that opens the way for victims to seek compensation on a broader scale. A Japanese official injects a vaccine against Covid-19. Photo: Reuters. The Japanese government did not appeal the ruling. Vaccination was also no longer mandatory after the government revised the law in 1994. Since then, vaccination rates in Japan have declined as parents become more concerned about side effects. The AIDS crisis also has a negative impact. In 1996, a Japanese health ministry official was convicted of negligent manslaughter following a scandal involving HIV-contaminated blood products. Despite the government’s efforts to hold responsible, the incident still made officials in Japan feel that they would suffer the consequences if anything happened, while the politicians were unharmed. Gaps in policy Japan is currently facing a “vaccine gap”. In the US and Europe, the product licensing process takes only a few years, but in Japan it is more than 10 years. The Japanese Ministry of Health has issued a special license for the Pfizer vaccine to be administered to the elderly, but this licensing process only applies to foreign vaccines. Meanwhile, the US administration has accelerated vaccine development since the 2001 anthrax attack. When there is a public health crisis in the country, the US Department of Health and Human Services will coordinate with other agencies. research institutes and pharmaceutical companies to respond appropriately. The agency also supports development budgets, clinical trials, as well as emergency approvals. The global vaccine market is growing by nearly 7% per year. New vaccines are released every time a new deadly infectious disease emerges, such as Middle East Respiratory Syndrome (MERS) and Ebola. The mRNA technology used in making vaccines has been studied for the past 20 years and is being applied to fight Covid-19. But private companies in Japan can hardly solve this problem alone because of the lack of motivation to promote the development, purchase, or stockpile of vaccines. Japan currently does not have a domestically produced vaccine. Photo: AFP. “There is a gap in the vaccine because there is still a gap in policy,” said Tetsuo Nakayama, a professor at Kitasato University in Tokyo. One can mention the case of UMN Pharma, a Japanese biotech company that uses new technology to develop flu vaccines. UMN Pharma used to spend more than $100 million to build a manufacturing plant, but the company’s application for a license was rejected in 2017. The grounds for the rejection were that the product “lacked clinical importance” compared to vaccines. available. UMN Pharma currently has negative total assets and is owned by Shionogi – another Japanese pharmaceutical company. The vaccine made by UMN Pharma has been approved in the US. This has led one in the Japanese vaccine industry to question whether anyone still wants to make new vaccines in the country. Complicated legal regulations Technology and research talent are also flowing outside of Japan. “Japan has a lot of regulations but it has a weak support system,” said one virus expert. The country has only two research facilities that can handle the most dangerous viruses. But one of the two establishments has only recently reopened because it was previously opposed by the local people. Public Administration Reform Minister Taro Kono was appointed on January 18 as the person in charge of Japan’s vaccination campaign. Photo: Japan Times. Vaccine research in Japan is subject to complicated regulations by many ministries. Experiments involving gene editing are limited to the Cartagena Protocol. This is an international legal document on biosafety management with genetically modified organisms that Japan has approved. Meanwhile, Europe exempts pharmaceutical companies from applying the Cartagena Protocol. The United States has not yet ratified this document. Japanese manufacturers even ignore the domestic market. Takeda Pharmaceutical, for example, has no plans to license its dengue vaccine in Japan. The same thing happened with the vaccine made from tobacco leaves of Mitsubishi Tanabe Pharma company. In the immediate future, Tokyo has quickly appointed a minister in charge of the Covid-19 vaccine. But products made by AnGes, Shionogi, and other Japanese companies are not expected to be approved before 2022.