US Secretary of State in Berlin Solution to pipeline dispute by August?

Status: 23.06.2021 13:57

During his inaugural visit to Berlin, US Secretary of State Blinken demonstrated unity with his counterpart Maas. In the dispute over the Nord Stream 2 pipeline, an agreement is expected soon. The German government wants to find a solution to the transatlantic dispute over the Nord Stream 2 gas pipeline by August. This was announced by Foreign Minister Heiko Maas in Berlin after a meeting with US Secretary of State Antony Blinken. The Chancellor’s trip to Washington in mid-July would certainly also be a suitable date, said Maas. But in August the US Congress will again deal with possible sanctions. “It is extremely important to us to achieve results that can also be supported in Washington,” emphasized the SPD politician.

USA: Nord Stream 2 is “Russia’s geopolitical project”

Blinken warned that Russia could use energy to leverage Ukraine. “Our goal is to ensure that Russia does not use energy as a means of coercion, as a weapon against Ukraine or anyone else in Europe,” said the US Secretary of State, who told his counterpart Maas in the run-up to the second Libya conference met in Berlin. The US continues to believe that the pipeline is a geopolitical project by Russia that threatens Europe’s energy security. In view of the difference of opinion between Washington and Berlin on this point, Blinken emphasized: “It happens from time to time among friends.”

USA waived sanctions

For years, the US has been against the construction of the Baltic Sea pipeline, which is supposed to pump gas from Russia to Germany bypassing Ukraine. Nevertheless, in May the new administration of US President Joe Biden partially gave up its longstanding resistance to the project and waived sanctions against the operating company – also out of consideration for relations with Germany.

Since then, talks have been going on between Germany and the USA about how to proceed. In essence, it is about how Ukraine, as a previous transit country, can secure long-term income, since it is dependent on Russian billions for gas transfers. The corresponding contract between Russia and Ukraine is limited to 2024

Specifically, in order for businesses to promptly resume operations after the Covid-19 epidemic is controlled, the Vietnam Tourism Association will organize the VITM Hanoi Fair 2021 from July 29 to August 1. 2021 at the International Exhibition Center ICE Hanoi – Palace of Vietnam-Xo Friendship Culture (91 Tran Hung Dao, Hanoi). VITM 2020 has the participation of more than 300 units and obtained many excellent results Earlier on April 28, 2021, due to the complicated and unpredictable developments of the Covid-19 pandemic, the Vietnam Tourism Association announced to postpone the opening date of VITM Hanoi Expo 2021 to June 2021. . Although the time has changed, the Organizing Committee still retains the information that the units have registered. With the theme “New normal, new opportunities”, VITM Hanoi Expo 2021 will contribute to reactivating the tourism industry and related industries. In addition to B2B business contact activities, during VITM 2021, businesses also prepare demand-stimulating products to provide directly to visitors to the fair. On this occasion, the Vietnam Tourism Association will organize the awarding of VITA Awards, the launch of the MICE Travel Club and many conference and seminar programs./.

At the Fosun Pharma’s shareholders’ meeting held last week, Fosun Pharma stated thatBioNTechThe co-developed new crown mRNA vaccine Fubitai is still waiting for approval. At present, the approval process for pharmacy is basically completed, and the approval requirements and materials to be carried out in the follow-up have basically been sorted out.

Fosun Pharma: mRNA Covid-19vaccineAwaiting approval, the localized production line will be completed in August

Wu Yifang, Chairman of Fosun Pharma, revealed that “mRNA is a brand-new technical route. Under approval,countryThe Food and Drug Administration has some groundbreaking things to do, and we conducted in-depth exchanges throughout the process.countryThe Food and Drug Administration has given a lot of guidance and feedback is very fast. “It is understood that the matters required for the pharmacy-related conditional approval have been basically completed, and the subsequent conditional research and clinical requirements to be carried out are basically clear.

At the general meeting of shareholders, Fosun Pharma revealed thatBioNTechTechnology transfer and equipment ordering are already underway.BioNTechDispatchedexpertI have gone to the Jinshan plant in Shanghai to work with the Fosun Pharma team. Both parties have a daily meeting on various professional working groups. The localized production line is expected to be completed in August,beginnormal production.

Source: Network

Some people in the industry have put forward a point of view that Fosun Pharma and Germany’sBioNTechIt belongs to the joint venture agency model, and its essence is to exchange technology for the market.

As early as May 9, Fosun Pharma issued a major announcement stating that its holding subsidiary Fosun PharmaBioNTechInvest in the establishment of a joint venture company to realize the new mRNA crownvaccineLocalized production and commercialization of products.

At the beginning of last year, the two parties signed a license agreement, agreed to pay a license fee and pay a sales commission based on a certain percentage of the product’s annual gross profit.forGuaranteeChinese market mRNA Covid-19vaccineSupply, Fosun Pharmaceutical Industry andBioNTechSigned the “License Agreement Amendment One” on December 15, 2020, to promote mRNA COVID-19 in stages such as the import of finished products, the import of large-package preparations in China (excluding Hong Kong, Macao and Taiwan), and localized production.vaccineChina sales and supply reached an agreement.In order to further implement the relevant mRNA new crown in the “License Agreement Amendment One”vaccineArrangements for localized production, both partiesup to dateThe announcement announced the signing of the “Terms”, the establishment of a joint venture company, and an agreement that Fosun Pharmaceutical Industry should provide an annual production capacity of up to 1 billion doses of mRNA.vaccineProduction facilities and injected the facility as part of the capital contribution into the joint venture company.

onvaccineFor subsequent commercialization issues, the two parties agreed that the joint venture company will hire an affiliate of Fosun Pharmaceutical Industry as the CSO to provide mRNA new crowns in China (excluding Hong Kong, Macao and Taiwan)vaccineMarket and sales services, and pay corresponding fees to the CSO in accordance with the contract.

Subsequently, at the beginning of 2021, the BNT162b2 vaccine (Fobitai) was approved for emergency use in the Hong Kong Special Administrative Region and Macau Special Administrative Region respectively, and was used in the vaccination programs of the above-mentioned two regional governments in March.

According to CCTV News, as of June 14th, 31 provinces, municipalities (including the Corps) across the country had cumulatively reported vaccination against the new crownvaccineThe number of doses exceeded 900 million, even if Fosun Pharma’svaccineWhen approved, how much market will be left to it is a question of great concern to many investors.

There are barriers to the production technology of mRNA vaccines entering the sprint stage

At present, the domestic competition for the approval and listing of mRNA vaccines has entered a fierce stage.In addition to Fosun Pharma, the mRNA vaccines that Abbio is responsible for research and development, and Watson Bio is responsible for the production and promotion of mRNA vaccines are the current domesticthe firstA mRNA vaccine that has entered clinical phase III. On May 11, the Mexican Foreign Minister announced that the mRNA new crown vaccine developed by a Chinese companyARCoVWill start in Mexico on the 30th of this monthIIIPhase trial, it is estimated that 6000 volunteers will participate, thisvaccineIt is the joint research and development of the Military Academy of Sciences, Aibo Biology, Watson Biology, and the three parties.

Different from the cooperation model of Fosun Pharma, the research and development of Aibo Biological and Watson BiologicalARCoVThe vaccine has independent intellectual property rights, and itscoreThe raw materials and key equipment have been made domestically. In December 2020, Watson builds China’s first mRNA new crownvaccineProduction workshop,ARCoVThe vaccine is expected to be completed and put into production within 8 months, with a production capacity of 120 million doses per year in the first phase.

It has always been a concern in the industry that the domestically produced mRNA vaccines of Watson Biologics and Fosun Pharma will be the first to cross the line in China.Former Shanghai Center for Disease ControlvaccineExpert Tao Lina believes that Fubitai is an imported product after all. If it is successfully approved for listing in the future, it is most likely to be listed conditionally.He told Ao Yi News reporter that, in comparison, the local company Watson Biotech may have an advantage in production. “After all, it is our local Chinese company, and Fosun andBioNTechBecause of the cooperation model, it may be slower in production. ”

Regarding the localized production of Fubitai, Fosun Pharma stated that the company hasBioNTechTechnology transfer and equipment ordering are already underway.BioNTechDispatchedexpertI have gone to the Jinshan plant in Shanghai to work with the Fosun Pharma team. Both parties have a daily meeting on various professional working groups. Fosun Pharma expects that the joint venture agreement will be implemented in June 2021 and the localized production line will be completed in August.beginnormal production. According to Wu Yifang, in terms of production capacity design, considering that the production line will be transferred to other mRNA vaccines and global demand, production capacity will retain the possibility of growth.

Earlier, Abbio and its partner institutions introduced its mRNA COVID-19 vaccine in a paper published in the journal Cell in September 2020.ARCoVProduction process. The paper introduces that the aqueous solution of mRNA and the ethanol solution of lipid molecules are quickly mixed, so that the lipid molecules form LNP that encapsulates the mRNA, and then the ethanol is removed by tangential flow filtration and concentrated to obtain the original solution.

Although the above process seems simple, the founder andchiefIn an interview with the media, executive InBev pointed out that it involved the determination of a large number of process parameters.coreTechnology”. The determination of these parameters fundamentally determines the performance of the product, and only a few companies have it.

Tao Lina introduced to Ao Yi reporters that the two domestically producedvaccineThere are two differences in the technical details: Fubitel uses all the S protein of the virus asvaccineTarget ingredient, WatsonvaccineUse the RBD region on the viral S protein asvaccineTarget component. RBD is the key to the virus being able to attach to human cells. The mutation is not large. If the mutation is large, it may not be able to infect the human body.vaccineIt may be more effective in dealing with virus mutations; in addition, there are other areas on the S protein that can stimulate the body to produce antibodies. These antibodies may not have the effect of neutralizing the virus, and theoretically may also lead to ADEeffect, Which helps the virus infect the human body.So, theoretically, the RBD vaccine may be moreSafetysome.The lipid carrier used in both is LNP, but Fubitai must be cryopreserved, WatsonvaccineIt is announced that it can be stored at 2-8 degrees.

HaitongInternationalAccording to the research report, there are many difficulties in mRNA production. One is that the carrier used is usually nanometer-sized, with a diameter of usually less than 200 nanometers, so the production process is more demanding; in addition, the capping rate will also affect the activity and side effects of the product. However, the preparation process has a great influence on the stability of the product, and how to maintain the purity of the product is also a challenge. “Capping” is the process of modifying mRNA molecules.

“Fragrant Rice Cakes” in the Capital Market: What is the prospect of mRNA?

With the outbreak of the new crown epidemic in 2020, mRNA vaccines became famous in the first battle.

Former Shanghai Center for Disease ControlvaccineExpert Tao Lina told Ao Yi news reporter that in the new crownvaccinePreviously, most of the early work on mRNA vaccines focused onTumoraspect.cancerThe vaccine istreatmentSexual, not preventive, aimed atTumorPreferentially expressed by cellsTumorRelated antigens, therefore, stimulating cell-mediated immune responses can reduceTumorburden.

In this new crown epidemic, the unprecedented cooperation environment and government investment have prompted effective data and large-scale applications tovaccineProvides a conceptualverification.Government support helps manufacturers scale up at risk while gainingthe firstBatch validity data. Two foreign companies that first developed mRNA vaccines——BioNTech(Bintech),Moderna(Modena) Announced separatelyIIIClinical data,ModernaIn the clinical data of (Modena), among 30,000 vaccinators,vaccineThe effective rate is 94.5%, and the critical illness protection is 100%. November 9, 2020BioNTechofIIIPhase clinical data released, mRNA vaccineThe effective rate exceeds 90%.

Tao Lina believes that the mRNA vaccine is effective, and the corresponding vaccinators should also receive a “greater response.” “ThisvaccineTo stimulate antibody immunity and cellular immunity at the same time, and cellular immunity will release a lot of cytokines, leading to adverse reactions in the vaccinated person. “He thinks that because there are other less reactivevaccineFor reference, it is not ruled out that the people will inoculate different types of vaccines according to their own acceptance.vaccine.

Since the outbreak of the new crown epidemic, there have been many cases of cooperation between domestic pharmaceutical companies and mRNA companies:

On May 20, 2020, CanSino and Precision Canada NanoSystems(PNI) companies jointly developed a technology based on mRNA lipid nanoparticles (mRNA-LNP)vaccine；

On December 7, 2020, Zhifei Biological announced that it plans to subscribe for 10.189% of the shares of Shenxin Biological with its own funds of 35 million yuan to deploy the third-generation mRNA vaccine technology platform.

On May 9, 2021, Fosun Pharma invested 100 million U.S. dollars to cooperate with a German biotech companyBioNTechSet up a joint venture company to realize the new mRNA crownvaccineLocalized production and commercialization.

It can be said that the outbreak of the new crown epidemic has pushed the mRNA pharmaceutical industry to an unprecedented climax, and the domestic mRNA pharmaceutical industry has finally ushered in the spring of development.

Large-scale financing of mRNA technology companies has also received attention. Just at the beginning of June, Si Microbiology announced that it has officially completed a new round of financing of 200 million US dollars, breaking the record of a single financing for domestic mRNA companies.At the “2021 Pujiang Innovation Forum” held recently, Li Hangwen, founder, chairman and CEO of Sri Microbiology, stated that mRNA vaccines should have become the world’s most frequently administered vaccine.vaccine, Both in clinical trial results and in the real world have shown good results, suchvaccineIt can also be adjusted quickly to deal with virus mutations. In addition, unlike many traditionalvaccineCompared with the development route, mRNA vaccines can activate stronger cellular immunity.

Gao Fu, director of the Chinese Center for Disease Control and Prevention, once stated at an industry conference that mRNA technology is effective for infectious diseases,AIDS, Genetic diseases, rare diseases,TumorWill provide various opportunities, hoping to develop classic traditionsvaccineWhen considering the benefits that mRNA vaccines may bring to humans.

Ao Yi News reporter Lin Shiyan

Samsung Electronics Co.’s Galaxy S21 smartphone on display at a store in Seoul. Photo: Yonhap According to industry sources on May 9, Samsung, the world’s largest smartphone vendor, is in talks with local mobile service providers about launching new smartphone models. Galaxy S21 FE, Galaxy Z Fold3 and Galaxy Z Flip2 at the end of August. If approved, these new smartphone models will be released sooner than usual. Industry experts say the early launch of these new smartphone models is intended to fill the void of the Galaxy Note phablet line that is launched in August every year. Samsung has not confirmed any information regarding upcoming smartphone models, but technology experts predict that the Galaxy Z Fold3 lineup is the first smartphone to fold screens with camera below the screen and has support for S-Pen stylus. Samsung was the world’s leading smartphone supplier in the first quarter of 2021 after shipping 77 million smartphones, accounting for 23% of the market share, according to market research firm Strategy Analytics.

According to Mr. Le Tan Thanh Tung, Deputy General Director of Vietnam Tourism Joint Stock Company (Vitours), the company is focusing mainly on the domestic market and has prepared most carefully to welcome visitors this summer. As long as domestic epidemic control is good, domestic tourism will thrive, Tung said. It is predicted that in the second half of May to the end of August, domestic tourists will boom strongly. If visitors who previously went abroad, people waited until 2020 until 2021, they will still not be able to travel abroad, this year will definitely go in the country as long as we are under control of the epidemic. “In my opinion, this object will help recover 70-80% from the time when tourism thrives in 2019. We have now fully prepared for transportation, accommodation and especially human resources. service forces, guides, to be ready to welcome visitors “, said Mr. Tung. Da Nang beach was crowded again on weekends, including many tourists. Ms. Tran My Quyen, Deputy Director of Hanh Huong Viet One Member Limited Company, said that in the summer, tourists want to tour in the direction of family, group of friends and want to go to places of entertainment, swimming and relaxation. check in the beautiful landscape. Therefore, the company has given many options to meet all requirements of all components and groups of customers. For example, cooperating with other travel companies to sell vacation tours connecting Da Nang with other lands and localities (Hue, Hoi An, Da Lat, Phu Quoc, Ha Long, Con Dao. ..). “We continue to explore resort services at homestays, villas, 4-star hotels or more with swimming pools and buffet and eco-tourism areas, vegetable gardens … At the same time, price promotions. Best for travelers who choose tours with experience activities on the sea such as rowing, fishing, swimming, … combining rustic tours, camping, fire, overnight cultural exchanges, pick me up … like a tour “ Thong Son Cha “That we have introduced to visitors”, Ms. Quyen shared. Tourists are excited to experience yachts watching the Han River at night. Identifying the tourism trend this year has a big change, with the first priority of visitors is ensuring health safety, Ms. Le Thi Bich Huong, Marketing and Communication Director of Mineral Park Tourist Area hot Nui Than Tai (Da Nang), said the unit focused more on the quality of the destination, interested in medical tourism and health care, towards ecology. “In preparation for the tourist recovery this summer, Nui Than Tai Hot Spring Park renovated and put into operation new service items to increase the experience for visitors such as renovating and expanding the mineral lake. Hot Huyet Long Ho with new lake clusters, planting more orchid species to create a fresh landscape; both taking care of your health but meeting the need of taking check-in photos for visitors, creating for visitors to like To be in harmony with nature At the same time, we add the Himalayan salt rock sauna, with free Japanese style Onsen bath service to help visitors have more new experiences … to meet the needs tourism demand for health care “, Ms. Huong shared. Mr. Nguyen Son Thuy, Director of Dong Duong Duy Nhat Tourism Co., Ltd said, in the past year, tourism businesses not only of Da Nang but also neighboring localities have very close links to create. products to stimulate demand according to customer needs. The new trend of domestic tourists is going in small groups, choosing safe spots, so tourism businesses also choose to increase service values, increase new experiences for tourists at their tourist destinations. Da Nang in particular, Central in general. “Enterprises are proactively diversifying products, building products close to nature, targeting the practical needs of domestic tourists to attract tourists in this tourist season,” said Thuy. know. All destinations measure body temperature, are equipped with masks, disinfectant water … for customers to ensure safety. According to the General Director of Tourism Nguyen Trung Khanh, in 2021, the tourism industry determined that domestic tourism is still the main direction of exploitation. To do that, localities need to support businesses, especially mechanisms and policies to attract visitors back; building new tourism products suitable to the context and needs of tourists. For Da Nang, the city has been very creative in developing tourism stimulus programs that are attractive in both price and quality. This shows the determination of the city tourism industry, as well as the local tourism businesses. “Da Nang needs to identify specific solutions to both recovering and doing business in tourism; concentrating on domestic tourists as the main source, but also preparing plans to welcome international visitors when eligible and available. appropriate policies to attract returning visitors Special attention should be paid to the structure and reconstruction of unique and attractive tourism products suitable for new types of tourism such as sea resorts, mountain resorts, health care, short-term travel … At the same time, ensuring quality human resources for the tourism industry when activities are gradually returning “, said Mr. Nguyen Trung Khanh. More than anyone, each tour company must commit to ensuring the 5K criterion when welcoming tourists on their tour. It is necessary to keep the safety on the tour so that we can hope and expect the exciting return of the tourism industry in the coming time.

German soldiers, joining NATO missions in Afghanistan, patrol in the Mazar-i-Sharif area, April 26, 2016. Photo: AFP / VNA

According to the VNA correspondent in Berlin, in his April 16 statement, German Defense Minister Kramp-Karrenbauer emphasized: “If everything goes according to plan, all German forces will leave Afghanistan by mid-August. “. This means German troops will leave Afghanistan by 9/11.

According to Minister Kramp-Karrenbauer, with the withdrawal of troops from Afghanistan, the deployment of German troops in the country ended “after nearly 20 years for the most lost and heavy duty in German military history”. She emphasized that the primary goal is to bring all soldiers, civilian personnel and international teammates back to their homeland healthy and safe. In addition to the US forces, there are about 7,000 foreign soldiers deployed in Afghanistan, including about 1,300 German soldiers.

Earlier on April 14, the NATO Council decided to join the US to begin withdrawing troops from Afghanistan from May 1. According to US President Joe Biden, the withdrawal lasted until September 11, the 20-year period of terrorist attacks on the twin towers of the World Trade Center in New York and the ministry. Defense of the US in Washington, the capital, the reason for the US to launch the war later in Afghanistan.

At a previous conversation between German Chancellor Angela Merkel and US President Biden, the two sides agreed to cooperate regarding NATO’s military presence in Afghanistan. According to German government spokesman Steffen Seibert, the German and American leaders emphasized the importance of close coordination and cooperation as well as continued political commitment to the waning Southeast Asian nation. demolition after decades of war.

Despite the planned withdrawal, the United Nations (UN) still wants to continue its political and humanitarian mission in Afghanistan. United Nations spokesman Stéphane Dujarric stressed: “We will study the situation further, but our work in Afghanistan will continue. It is clear that the withdrawal of NATO and the US forces will have an overall impact on the country, he said. According to him, the UN has a long presence in Afghanistan, working in the field of humanitarian development. The United Nations Assistance Mission to Afghanistan (UNAMA) consists of about 1,200 personnel, most of whom are Afghan citizens, and does not include a peacekeeping force.