According to Lieutenant Colonel, Associate Professor, Assoc. Prof. Dr. Chu Van Men, Director of the Center for Clinical Trials and Bioequivalence, Military Medical Academy, phase 3 injected the Nano Covax vaccine to 13,000 people and administered only a single dose group injection. at least 25 mcg and the placebo injection group. Specifically, according to the protocol approved by the Ministry of Health, the first 1,000 trial injectors of the first phase of phase 3, the volunteers are injected with the ratio of “6 people vaccinated, 1 person injected placebo”. The remaining 12,000 people injected according to the ratio “2 people vaccinated, 1 person injected placebo”. It is expected that the first phase of phase 3 will be conducted by the Military Medical Academy and the Pasteur Institute in Ho Chi Minh City with 1,000 volunteers, each with 500 people. Vietnam’s first COVID-19 vaccine tested in phase 3 on humans. Regarding the reason for choosing the dose group of 25 mcg, Assoc. Prof. Dr. Chu Van Men said that testing at 3 dose levels of 25-50-75 mcg showed that the vaccine was safe on volunteers, capable of generating immunity in 3 doses. There was no difference in dose groups. Therefore, the National Ethical Council in Biomedical Research, Ministry of Health decided to only inject 1 optimal dose of 25 mcg at this stage. Phase 3 is implemented in many centers in the country: The North is deployed by the Military Medical Academy as the focal point at Military Medical Hospital 103, in collaboration with the Preventive Medicine Center of Hung Yen province to deploy locally; In the South, the Ho Chi Minh City Pasteur Institute is the focal point to deploy, in collaboration with the Preventive Medicine Centers of Long An and Tien Giang provinces to deploy locally. After the phase 1 and phase 2 trials, the Nano Covax vaccine is judged to be quite safe, so the criteria for recruiting volunteers will be relaxed more than the previous two phases. 13,000 volunteers participating in phase 3, aged 18-75 years old, only need to check their blood count and check for antibodies to the SARS-CoV-2 virus. People who have been exposed to the SARS-CoV-2 virus or already have antibodies will be excluded from the test population. As of June 11, more than 6,500 volunteers have registered to test the Nano Covax vaccine against COVID-19 phase 3. Senior Colonel, Assoc. Prof. Dr. Ho Anh Son, Deputy Director of the Military Medical and Pharmaceutical Research Institute, Military Medical Academy added: “It is expected that by mid-September 2021, after about 42 days of the second injection. In two of the first 1,000 experimental injections, we will summarize the results of the quality assessment to report. If it is favorable, we will submit the dossier and propose the Government, the Ministry of Health, and the National Ethical Council in the study. In parallel with that process, the unit will continue to test the Nano Covax vaccine on 12,000 volunteers to continue to control the experimental injection and evaluate the effectiveness. protective power of vaccines”. During the testing process and after the antibody sample is available, the Military Medical Academy will coordinate with the Nanogen Pharmaceutical Biotechnology Joint Stock Company, the testing units to conduct the assessment of the ability to neutralize the SARS-CoV virus. -2 in the laboratory for existing virus strains to determine the development direction of vaccine research in the coming period. Through discussions with the expert group of Nanogen Pharmaceutical Biotechnology Joint Stock Company, in addition to recombinant protein technology, there are other technologies for research and production of vaccines. Nanogen as well as many Vietnamese scientists are very interested in mRNA technology – which has been of great interest to the world in recent years. This technology has the advantage of reacting very quickly to the disease, quickly getting a vaccine. According to available information, vaccines produced by this technology are very safe for human use. More information about the phase 3 trial, Lieutenant General, Prof. Dr. Do Quyet, Director of the Military Medical Academy, said that this trial phase is designed according to the adaptive design method, continuing to inject the experimental vaccine. trial and placebo group; health assessment at the time of the first injection, the second dose (done on the 28th day), the 35th day and the 42nd day after injection. The Director of the Military Medical Academy expressed confidence in the safety of the Nano Covax vaccine with the results achieved through the previous two testing phases. Specifically, the concentration of SARS-CoV-2 virus antibodies after the phase 2 trial injection showed that the antibody titre increased very high, from tens to hundreds of times. After the second injection, the volunteers had a physical examination (blood test, blood pressure measurement…) once a week to assess the amount of antibodies appearing in the body; then continue to be monitored for 6 months to get information, assess health as well as immunity ability. Up to now, 100% of volunteers who have been vaccinated with Nano Covax vaccine have produced antibodies in the blood. – Phase I (December 2020), the COVID-19 vaccine Nano Covax was administered to 60 volunteers. – Phase II (February 2021) injected over 554 people. From phase 2, the trial was conducted both at the Military Medical Academy and the Medical Center of Ben Luc district – Long An province (by the Pasteur Institute in Ho Chi Minh City).

Illustration. At the meeting of the National Steering Committee for COVID-19 prevention and control on the afternoon of June 11, Deputy Minister of Health Tran Van Thuan informed that the Ministry of Health had officially approved the phase 3 clinical trial of the vaccine. Vietnam’s first COVID-19 room named Nano Covax. According to Deputy Minister Tran Van Thuan, the Ministry of Health has just approved the phase 3 clinical trial of Nano Covax vaccine of Nanogen Company. According to Lieutenant Colonel, Assoc. Dr. Chu Van Men – Director of the Center for Clinical Trials and Bioequivalence, Military Medical Academy, Ministry of National Defense, phase 3 injected the Nano Covax vaccine to 13,000 people and injected only a single dose group. 25 mcg and placebo injection group (with a ratio of “6 people vaccinated to 1 person injecting placebo” according to the design approved by the Ministry of Health). As for the reason for choosing the 25 mcg dose group, Assoc. Prof. Dr. Chu Van Men said that when the phase 2 trial showed that, the 3 dose levels of 25-50-75 mcg had equivalent safety and immunogenicity. undifferentiated. Therefore, in order to ensure the safety and increase the effectiveness of the number of doses of vaccine production, the National Ethical Council in Biomedical Research, the Ministry of Health decided to inject only 1 optimal dose of 25 mcg at the initial stage. this. Minister of Health Nguyen Thanh Long and Minister of National Defense Phan Van Giang asked and encouraged volunteers to test the vaccine against COVID-19 Nano Covax. Photo: PV. On June 11, the Military Medical Academy said that this unit has started to deploy the phase 3 trial injection of the COVID-19 Nano Covax vaccine for the first 19 volunteers. On the day of injection for 200 people, divided into 2 groups. Accordingly, one group injected the Nano Covax vaccine with a dose of 25mcg, the other group injected a placebo with aluminum excipients. Military medical students will inject 1,000 volunteers in the first time. According to the research outline, phase 3 will test on about 13,000 volunteers in many provinces such as Hanoi, Hung Yen, Long An, Tien Giang… At the Military Medical Academy, there are currently more than 7,000 volunteers registered to participate in the trial, of which more than 600 people have been screened and are eligible to participate. Besides, IVAC’s Covivac vaccine is also preparing to complete phase 1 trial and enter phase 2 in July 2021. Regarding the subjects of vaccination, according to Deputy Minister Tran Van Thuan, in addition to the priority subjects for COVID-19 vaccination under Resolution 21, the Ministry of Health has added workers in industrial zones and will propose more subjects working in establishments dealing in essential goods.

Illustration GS. Dr. Truong Viet Dung, Chairman of the National Ethics Council in Biomedical Research, said in the SK & DS newspaper, in phase 3, the subjects of the Nano Covax vaccine trial in Vietnam will expand. The object here means the area, which can be extended to other areas such as workers in industrial zones. However, areas or industrial zones with COVID-19 cases were not selected for clinical trials because it would be interpreted as the epidemic situation that made people too worried and accepted to participate in the research. Therefore, research can only be carried out in industrial zones at risk of disease outbreaks, not in industrial zones with epidemics. Testing participants for COVID-19 to confirm the absence of antibodies is required. In the spirit of “testing as quickly as possible” of the Government, the Ministry of Health assigned testing units. Fast does not mean cutting, skipping stages. Any stage must comply with international requirements and standards. Do it very quickly but must be very standard, giving it to the Council must be approved immediately. In general, in accordance with the process and step by step of each phase, so that the Ministry of Health has enough scientific basis to be able to grant urgent and conditional use of Nano Covax vaccine in Vietnam. Information on Vietnam plus, Deputy Director of Military Medical Research Institute Ho Anh Son said that according to the latest information, it is possible that as soon as next week (expected in early June 2021) will enter vaccine research. Nano Covax phase 3 with the expected number of volunteers to participate is about 13,000 people. In phase 3, the implementation is very fast, following the correct process, and at the same time meeting the needs of disease control in Vietnam. Up to now, the Military Medical Academy has mobilized a lot of doctors, technicians, students… to participate in the testing process so that it can be ready for deployment in 10 provinces/cities across the country at the same time. country. After testing phase 1 and phase 2, Nano Covax vaccine is quite safe, so the criteria for recruiting volunteers will be relaxed more than the previous 2 phases. Volunteers participating in phase 3 from 18-75 years old, only need to check the blood count and check for antibodies to the SARS-CoV-2 virus. People who have been exposed to the SARS-CoV-2 virus or already have antibodies will be excluded from the test population. More about the phase 3 trial, Lieutenant General, Professor-Dr. Do Quyet, Director of the Military Medical Academy, Ministry of National Defense said that he believes in the safety of the Nano Covax vaccine with the results achieved. through the previous two phases of testing. According to the Director of the Military Medical Academy, immunogenicity is reflected in two main factors: antibody concentration and antibody immunogenicity. Specifically, the concentration of SARS-CoV-2 virus antibodies after injection of the phase 2 trial showed a very high increase in antibody titres, from tens to hundreds of times. Antibody immunogenicity to assess the ability to neutralize SARS-CoV-2 virus living at the 35th day of good response, above the prescribed threshold. As for the ability to neutralize the virus at day 42, the team has now evaluated 22/110 samples; expected to be completed in early June 2021 to report to the National Ethics Council in Biomedical Research. Phase 3 aims to evaluate the protective effect of the vaccine on the community, designed in many centers, expanding to other localities with a larger number of samples with only 1 injection. Based on the results of the evaluation, the National Ethical Council in Biomedical Research selected the experimental injection of 25mcg dose. Strictly following international guidelines, the National Ethical Council for Biomedical Research also identified a phase 3 trial in 10,000 people. Military Medical Academy complies with the approved outline and deploys to recruit volunteers.

Illustration Ronilza Johnson, 46 years old, a British citizen, has just died in a hospital in the city of Anapolis, Brazil, due to a cheap butt lift plastic surgery. The incident shook the beauty world in general and the beauty industry in particular in England and Brazil. Accordingly, during a trip to Brazil, Ronilza Johnson, introduced by a few friends, decided to do butt lift surgery at a underground facility. After surgery by biomedical scientist Lucas Santana, this man claimed to be able to perform butt lift surgery at a dizzying price. Specifically, only 2,000 pounds (nearly 2,800 USD), with the help of a medical student was able to perform major surgery to upgrade the buttock. A very cheap price, while in Vietnam, third-round surgery has to cost you from 75 million VND to hundreds of million VND depending on the quality and the service as well as the warranty that comes with it. Due to complications after butt lift surgery, Ronilza Johnson did not return to the grief of relatives and family. Ronilza Johnson was hospitalized with an infection following a butt-lift surgery in Brazil. Butt lift surgery is what? Butt lift surgery is basically understood to remove the skin layers, excess fat due to loss of elasticity and make the third ring sagging. Butt augmentation with surgery differs from butt pump or butt bag placement in that fat grafting or muscle lifting is taken from the body of the person wanting to have surgery and reconstructing the surrounding tissues to create a toned butt and round stretch. The Kylie sisters’ buttocks are the desire of all women in the world. Who can do butt lift surgery? The person who lifts the buttock by surgery must have enough butt skin to perform the procedure, be free of alcohol, smoke, and have good health and a healthy lifestyle. Diet must also be healthy and scientific, and especially to have an optimistic spirit, learn carefully about plastic surgery as well as go to reputable hospitals, leading in the field to lift buttocks. avoid panic and excessive anxiety. Complications of butt lift surgery: Blood loss, too much hematoma. The wound is difficult to heal, leading to necrosis. Leaving scars to lose aesthetics of the third circle. Prolonged swelling and swelling due to weakness. Pain and tenderness, may not be able to sit for long periods of time. The buttocks are skewed, unequal. And most importantly, over the years, the skin of the buttocks will sag again. May not be able to sit for long periods after butt lift surgery.

Illustration. “We don’t want to talk, because people ask me to share. Actually, Bkav researched Corona virus vaccine (Covid-19) a year ago, ”Mr. Quang told VnEconomy a few minutes ago, regarding a recent online discussion about Covid-19 and he revealed. Bkav has established a new generation vaccine research group. Bkav Chairman said that after finishing the first epidemic, around May 2020, Bkav went to meet with representatives of the Central Epidemiological Party to learn about vaccines, and this activity of Bkav came. Currently still in theoretical research phase. Mr. Nguyen Tu Quang. The new technology vaccine is like making a chemical – 3D printed – that gives the shape of a virus “to fool the body into making antibodies”. “At that time, Bkav’s Institute of AI Technology set up a group to specialize in researching vaccines and epidemic prevention issues, which Mr. Quang said he often shared. Research activities on this vaccine are still going on, ”said Bkav Chairman. According to Mr. Quang, now the new generation vaccine mainly uses technology. Vaccines are like 3D printing. Conventional vaccines have to be grown on other hosts or have real samples and then transplanted to other things before it can be replicated and vaccinated. While new technology vaccines are like creating chemicals, but in 3D printing with nanotechnology, the technology content is very high. This vaccine can be produced in large quantities, and cultured normally cannot do much. According to this leader, the field of research and production of vaccines is very potential because the technology is very high. Because you can imagine virus variation very quickly. If the traditional method of making vaccines responds to variations is many years. But the new method can be adjusted immediately by technological measures … like programming. To put it simply, it is very related to Bkav as programming anti-virus software in your computer, this is a program to create a new virus shape corresponding to a variant virus, like programming anti-virus software. So, Mr. Quang added. Vietnam’s current vaccine technology, according to Bkav President, is still using mainly culture, of course there is also new technology in culture, but the efficiency is still low – it is difficult to produce hundreds of millions of doses. Whereas the new technology vaccine is like making a chemical – in 3D printed form – that gives the shape of a virus “to fool the body into making antibodies”. This is like programming to make vaccines, and technology plays an important role. Mr. Quang also said that when he met with the leader of a vaccine manufacturing company, the leader also analyzed research and production of new generation vaccines now that the technology factor occupies more position – the computer, programming, is information technology, with a lot of content. Of course, there must be knowledge about biomedical science, so Bkav has recruited more human resources in this biomedical field. However, according to Mr. Quang, this is a long-term story, of many decades, not a day or two. And in fact, new technology vaccines have been studied for decades, so when facing the urgent “Covid” period, they were immediately brought to the market and confirmed that they are effective. Why does Bkav want to participate in this field? Mr. Quang questioned and explained to VnEconomy that, as the “Covid disaster” has been going on, the coming here will not be a nuclear weapon and a biological weapon, which everyone can see. And if there is no technology to make vaccines with new technologies, it is “difficult to survive” with viruses similar to Corona virus. Second, according to Quang, in the world today, the production of vaccines depends on several companies, so Vietnam must also master new vaccine production technologies. . “Especially in Vietnam with a hundred million people, we have to master such things, as before, other vaccines we also have to master. Bkav’s goal in entering this field is to master new vaccine technologies, and this is something technology companies must take part in, ”said Bkav Chairman Nguyen Tu Quang. And only that, according to Mr. Quang, if an epidemic occurs, Vietnam can take the initiative. Bkav’s “Vaccine Journey” is a long story with a vision of a biological weapon, after the Covid-19 story, there will certainly be more (large) countries that have more motivation to manufacture weapons. biogas, but Bkav must prepare (research vaccine) right now ”, said Mr. Nguyen Tu Quang.

People were tested with Nano Covax vaccine phase 2. In phase 2, the volunteers were divided into 4 groups, including groups of injections with doses of 25mcg, 50mcg, 75mcg and placebo. All 3 doses of 25mcg, 50mcg and 75mcg injected to volunteers were immunogenic, of which the 25mcg dose level is considered to be the most effective. The research team will report the results of phase 2 to the Ministry of Health. It is expected that on April 27, it will submit to the National Bio-Medical Research Ethics Council of the Ministry of Health a plan to deploy the clinical trial injection of Nano Covax vaccine phase 3. According to the plan, Nano Covax vaccine in this phase will be tested in large groups, from 10,000 to 15,000 people, starting from May 5-2021. The research team is expected to propose a single test injection dose of 25 mcg. Previously, as reported by the New Hanoi News, Nano Covax was the first Covid-19 vaccine in Vietnam to be injected for clinical trials in humans, researched and developed by Nanogen Technology Joint Stock Company. In phase 2, there were 560 volunteers registered for the trial, expanding the subjects from 18 to over 60 years old, of which, some people had background diseases such as hypertension, dyslipidemia, diabetes, heart disease. 1 degree circuit … not too heavy. The test vaccination of Covid-19 Nano Covax vaccine phase 2 was held at two bridge points: the Military Medical Academy and the Pasteur Institute of Ho Chi Minh City (participating in the study, conducted in Ben Luc district, province. Long An). For objective reasons, there were 4 people who asked to withdraw from the list of experimental injections. As a result, 556 people completed the second phase of Nano Covax vaccine trial. Step 1: Access to https://www.bluezone.gov.vn or directly download at App Store or Play Store. Step 2: Once downloaded, the app will ask for Bluetooth permission to record contact with other Bluezone installed users. If Bluetooth isn’t open, drag the status notification bar and turn on Bluetooth; Or go to Settings, select Bluetooth and turn it on. Step 3: After the installation is complete, click Scan Around. If someone near you less than 2m has used Bluezone, the application will automatically identify these users and put them on the contact list.

Scientists’ discoveries at the Smithsonian National Museum of Natural History (NMNH) and University of Florida (UF) have shown that marine biodiversity studies can enhance biomedical research. The naming of the compound Gatorbulin-1 (GB1) found in blue algae is a tribute to UF researchers and global partners who lit the torch for the discovery and traits of algae. lam. From self-defense to drugs Cyanobacteria are single-celled terrestrial and aquatic organisms around the world. They can use chemicals to defend themselves against predators. These chemicals also play a role in helping the cyanobacteria communicate. “ We studied a series of compounds called Quorum’s emotional inhibitors that affect the chemical signals that cyanobacteria have, ” said Dr. Valerie Paul, a chemical ecologist at Smithsonian Marine Station. used to communicate. The Quorum emotion is a name for the way bacteria communicate using chemical signals. The scientists examined the cyanobacteria’s communication and defense compounds to test for biomedical properties. Often they realize the compound’s medical potential before understanding why cyanobacteria take it. In a new study, GB1 was shown to have significant anticancer activity with the potential for a new drug formulation. But scientists are not quite sure how cyanobacteria use it. TS. Nature has optimized these compounds, which are created for a certain purpose, in the case of blue-green algae, said Paul, as self-defense. Chemical structure of Gatorbulin-1 (GB1) molecule. From the sea to the lab The blue-green algae targeted, Lyngbya confervoides, was discovered more than a decade before Dr. Paul started collecting this species. She quickly realized that the algae produced many different compounds, so she sent the samples to her collaborator Professor Hendrik Luesch for further study. But finding a new compound like GB1 that has the potential to make a new drug is a long process (not including the time it takes to add and test it to convert the compound into a safe, functional drug). The first stage of the procedure is to isolate and demonstrate that the purified compound can selectively kill cancer cells. Spurred by this discovery, Prof. Hendrik’s team was trying to find a way to synthesize the substance in the laboratory. A reliable way to produce GB1 is the first important thing to do in-depth research. “We like to stay in place to collect more cyanobacteria to isolate enough materials for advanced research,” Dr. Hendrik said. As organic chemists, we are able to replicate these natural molecules in larger quantities in the laboratory without having to depend on cyanobacteria. GB1 has been added to additional stages for the synthesis process. Scientists have discovered that GB1 targets a protein in cells called Tubulin – the same protein cells require during cell division and uses it to build ” internal scaffolding ”. While there are many chemotherapy drugs that target Tubulin, Prof. Hendrik and colleagues assert that GB1 is more special because it interacts with Tubulin in new ways. Now researchers are eager to see GB1 as effective in the real world as well as its potential to make anti-cancer drugs. The cyanobacteria that produced Gatorbulin-1 (GBI) was recognized as the algae Lyngbya confervoides. Healing ability of biochemistry Organic chemists often turn to nature to study drug formulation. For example, compounds in terrestrial life mechanisms such as plants and fungi led to the creation of important drugs such as penicillin that is now a staple of modern medicine. In the ocean, about three-quarters of the earth’s surface has yet to be touched by humans. “It’s really a chemical war in the ocean,” said Professor Hendrik. The more battles and communications like that will help us humans understand more about the active compounds that can apply to mankind. ” And Dr. Paul said: “From a chemical ecologist’s point of view, this biodiversity is equivalent to chemical diversity. We can find everything in the ocean we never dreamed of. ” Nguyen Thanh Hai ( (According to smithsonianmag) )