Marie Antoinette syndrome is a phenomenon in which a person’s hair suddenly turns white (depigmentation). The condition’s name comes from the folk tale of French queen Marie Antoinette, whose hair is said to have suddenly turned white before her execution on October 16, 1793. People often assume that this syndrome is caused by pressure – perhaps this is most evident in the photos of the head of state before and after taking office. Compare President Obama before and after taking office, retiring. However, because the specific mechanism of graying hair has not been elucidated, it is not clear that 3 factors of aging, genetic factors and stress will affect gray hair to what extent. Recently, researchers from Harvard University published a study in the journal Nature that identified the mechanism by which rat hair turns gray prematurely under stress. The average human scalp has 100,000 hair follicles, and humans also have many different hair colors. Hair color is determined by melanocytes, which produce melanin that absorb light in various combinations. Melanocytes are derived from melanocytes (MeSC), located in the protruding part of the hair follicle. The hair growth cycle is divided into three phases, namely the anagen growth phase, the catagen resting phase, and the telogen long metabolic (shedding) phase. Hair growth cycle: growth phase, resting phase and shedding phase (from left to right). Melanocytes are produced during the growth phase. As a person ages, the melanin stem cells will gradually deplete, and the pigment produced will have a “salt-and-pepper” color, then turn gray, and finally white – the pigment is completely lost. in all hair follicles. At first, researchers suspected that stress would trigger an immune attack on melanin stem cells. But this was later proven to be a false hypothesis, as the mice lacked immune cells but remained mutated and had white spots. Stress increases the secretion of the hormone cortisol, so researchers are beginning to suspect that the hormone cortisol is responsible for the hair color change. However, when the cortisol-producing glands were removed in the mice, the mice’s fur would still turn white. Finally, the scientists focused on the sympathetic nervous system, the system in the body that is used to control the stress response in dangerous situations. Through studies, scientists discovered that melanocytes are located in the bulging part of the hair follicle, surrounded by neurons of the sympathetic nervous system, and release a neurotransmitter molecule. nerve is called norepinephrine. Melanin stem cell activity under normal and stressful conditions. As can be seen in figure a, under normal conditions, melanin stem cells (MeSCs) migrated from the bulge (in the direction of the red arrow) and differentiated into melanocytes during the analysis. From there, melanocytes synthesize pigment to make the regenerated hair dark. During the degenerative and resting phase, these stem cells begin to die. However, in the next growth phase, there will still be a large amount of new MeSC used to replace the dead stem cells. In figure b, the researchers found that external pressure stimulates and activates the sympathetic nervous system, increasing adrenaline release in the hair follicles. Norepinephrine then causes the MeSCs to completely transform into melanocytes, and none of the stem cells survive the growth phase in the next cycle. Since no new melanocytes are produced, the hair is naturally greyish white. The researchers also tested the effects of different pressures on the fading of the mice’s fur. At different stages of hair growth, they exposed the mice to three different stressors – pain, limited mobility, and psychological stress. All three of these factors induce MeSC depletion, which eventually leads to the appearance of white hairs. Previous popular theories believed that stress-induced hormonal changes (such as corticosterone) or autoimmune reactions were responsible for graying hair. The researchers examined these underlying mechanisms, first by blocking corticosterone signaling, and then by stressing the mice’s immune systems. In either case, corticosterone changes or autoimmune responses did not induce MeSC depletion. However, the researchers found that the expression of MeSCs depends on an adrenaline receptor, which responds to adrenaline. The adrenal glands are the main source of adrenaline. But surprisingly, the researchers found that removing these glands still did not prevent the mice’s coat color from turning gray under stress. Another source of adrenaline is the sympathetic nervous system (SNS), which is active in response to stress. The researchers demonstrated that the bulge area is internally connected by sympathetic neurons. Using neurotoxin molecules to destroy the SNS or prevent sympathetic neurons from releasing adrenaline could prevent hair from turning gray due to stress. Next, the researchers studied mice with activated sympathetic neurons and found that over-activating the SNS in these mice could cause hair to turn gray without stress. Taken together, these results indicate that adrenaline released from activated sympathetic neurons induces MeSC depletion. The red shows the melanin stem cells at the bottom of the hair follicles and the sympathetic nerves are shown in green around them. Therefore, the culprit behind Marie Antoinette Syndrome is adrenaline, but our problem is not over yet. Stress produces adrenaline which turns our hair gray, so can a silvery bangs help relieve stress? The team from Harvard University, led by Xu Yajie, believes that hair-whitening is actually a side effect of sympathetic nervous system stress processing: “For species like octopuses and geckos flowers have the ability to change color rapidly, the pigment cells in their body will be activated under the influence of the nervous system, but in today’s mammals, only melanocytes remain. very sensitive to the hormones secreted by the nervous system. Once the hormone is secreted in excess, these cells are inadvertently activated.” Gray hair color is not life-threatening, so in the process of evolution, this small defect has remained. In fact, in the face of stress, hair doesn’t actually turn completely white overnight, which is a slow process and lasts for several months. In addition to being associated with stress and age, gray hair can sometimes be related to experience, leadership, and trust. For example, when a male silverback mountain gorilla is fully grown, it will grow gray hair on its back and become the leader of the gorillas. After being subjected to enough pressure, individuals that are “dyed” white often have a higher status in the community than their age.

Lack of sleep is also the reason for dark circles under the eyes. Lack of sleep: This is the leading cause of dark circles under the eyes. Because, not sleeping enough, staying up late regularly makes blood not circulate, lack of oxygen, the skin is not supplied with enough nutrition, thereby forming dark circles under the eyes and gradually causing wrinkles. . What are the causes of dark circles under the eyes and how to treat them? Constantly staying up late makes the skin under the eyes dark circles Genetics: According to the results of studies, there are many people with thin skin under the eyes or with many small blood vessels, the excessive distribution of melanin is due to genetics of parents. Due to lack of water: When the body lacks water, the blood vessels under the sensitive skin in the eyes will swell, causing puffiness and darkening. Due to a lot of sun exposure: The ultraviolet rays of the sun will stimulate the melanin pigment under the skin to increase. Due to smoking and using stimulants: Excessive use of tobacco, alcohol, and coffee causes blood vessels to constrict, causing poor blood circulation, causing wrinkles and dark circles under the eyes. Due to eating nutrients: Poor diet, little water intake, the body will react and that is manifested in the dark eye area. Cure eye bags with salt water Salt water can help you get rid of dark circles under your eyes. Step 1: First, prepare 1 teaspoon of salt (you can use large-grained salt or iodized salt) and dissolve it thoroughly with 100ml of hot water. Step 2: Wait for the mixture to cool completely, take a cotton ball or cotton pad and dip it into the prepared ingredients. Step 3: Next, wash your face with warm water to remove any remaining sebum on the skin. Step 4: After completing the steps, take a cotton pad and apply it in a circular motion to help blood vessels circulate best. Note: Never let water get into your eyes. Step 5: Perform continuously for about 10-15 minutes, then use a towel wrapped with ice cubes to apply a few more times to finish the beauty process.

Moreover, turmeric has an extremely fast disinfecting and healing effect. Although it brings many effects, many women are still afraid to use turmeric on their face for fear that it will be difficult to remove the yellow turmeric stains on the face, causing cosmetic loss. However, you do not need to worry too much, because the ways to treat acne with turmeric below can completely help you. How to treat acne with yellow turmeric powder Illustration. Turmeric starch is a product extracted from fresh turmeric root. The composition of turmeric starch is the same as fresh turmeric, so it is also very effective to treat acne. To treat acne with turmeric powder, you do the following: Mix 1 teaspoon of turmeric powder with 2 tablespoons of water. – Exfoliate, clean your face, then rinse with a little warm water. – Use a brush to sweep the turmeric mask on the dark scar area. Relax for 15 minutes then rinse with cool water, pat dry with a soft towel. Note when treating acne with turmeric – The yellow color of fresh turmeric on the skin is difficult to wash off with water. After applying the mask, you can use olive oil or fresh milk to clean the yellow stains of turmeric. – With fresh turmeric, you should choose the old turmeric, and the turmeric starch you use will not be lumpy. – Every day you should have a suitable lifestyle and proper skin care. Apply the mask about 2-3 times a week to ensure that the skin is always regenerated, the skin is bright and smooth, no acne, no dark spots. Clean your face twice a week.

How do ultraviolet rays affect the eyes? Eyes are very sensitive to any touch, including light. Looking at objects that are too bright for a long time, the eyes will quickly get tired, the feeling of eye pain appears. In the bright sunlight of summer, radiation from the sun easily causes blurred vision and premature degeneration… Therefore, protecting eyes from ultraviolet rays is very necessary. Ultraviolet rays appear in the sun, located in the 400-100nm wave band, appearing more and more, making eye diseases at an increased risk. If you look directly into the sunlight, it is more dangerous for your eyes. Ultraviolet rays (also known as UV rays, ultraviolet rays) cause eye burns, corneal damage, cataracts… The first harmful effects of ultraviolet rays can cause eye burns, easily encountered if we stand in the sun for a long time and do not have the protection with sunglasses, a hat. Symptoms of the disease are burning of eyelids, feeling of burning, itching, dry eyes and continuous blinking, blistering of endothelial cells. This phenomenon occurs a lot can lead to blurred vision, blurred vision. At first, ultraviolet rays only affect the eyelids and cornea. If severe, UV rays will affect the lens, leading to cataracts. In addition, damage to the endothelial cells of the retina leads to macular degeneration. Eye damage can be immediate or permanent after absorbing the UV rays present in the sun. In the eyelids, sunlight can cause some types of blepharitis, especially ciliary cancer such as basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. Normally, after being exposed to ultraviolet rays, from 6-15 hours, there will be visual disturbances such as decreased vision, seeing halos around light sources. After that, the patient will feel like there is a foreign object in the eye, watery eyes, very afraid of light. Usually, if progress is good, after 8 hours, these symptoms will go away on their own. In case of prolonged exposure to sunlight, ultraviolet rays can also cause more serious eye diseases such as retinal damage, cataracts, and even blindness. How to protect your eyes: The most important way to avoid sun damage to your eyes is to avoid direct exposure to the sun, avoiding the time when UV rays are the most, such as from 11am to 4pm. If we must work in the sun, we must find ways to limit the sun’s penetration into the body in many different ways such as wearing hats, wide-brimmed hats, covering the face… Ultraviolet every time you go out. Hair also needs to be shielded from the bad effects of the sun. Hair also needs proper sun protection Every day, the hair has to endure a lot of harmful effects from the environment: wind, dust, sun … making the hair worse and worse. At the same time, factors such as: age, aging process, daily hair care habits, abuse of dyes, excessively hot hair drying… are also causes of faster aging process. hair, causing the hair to lose more and more natural tolerance, become weak and break. To protect the hair, Health of life We recommend that you perform the following solutions: Sun protection for scalp and hair: Standing in the sun for a long time, especially when the scalp is wet from sea water or water from the pool, can easily cause the scalp to burn and become red. Therefore, you should wear a wide-brimmed hat to protect your hair from the sun. Rinse your hair with clean water before and after swimming: Another enemy of hair is chlorine in swimming pool water. The simplest way to reduce the impact of chlorine on the hair is to rinse the hair with clean water before swimming, helping the hair follicles to expand and fill with water, minimizing the amount of chlorine absorbed into the hair when swimming. After swimming, wash and rinse your hair thoroughly with clean water. Let your hair dry naturally: If possible, instead of using a blow dryer, be patient and let your hair dry naturally. While a hair dryer is convenient, it can easily dry, break and damage hair if not used properly. Daily you should use nourishing and care oils with essential protective ingredients such as moisture, UV protection. Make it a habit to steam your hair once a week to directly provide essential nutrients to your hair. Sunscreen spray for hair: You should not only protect your skin from the sun but forget about protecting your hair from the sun, UV rays and high temperatures from the sun. Your solution is hair-specific sunscreen sprays with UV protection that help protect hair from signs of damage without being greasy. Note: For healthy hair, do not wash your hair too much. After each wash, the scalp needs 48-54 hours to recover. When you wash your hair too much (wash several times a day or wash it every day) and use too much shampoo, you will make the oil layer on the scalp lose, the protective layer of the hair roots is affected, making the hair easy to fall and break. than. Eating enough nutrients such as vitamin B2 found in milk, meat, liver, bread helps healthy hair; vitamin B5 found in chicken, oranges, egg yolks… has the effect of nourishing hair; especially vitamin B3 found in yeast, fish, beans because this is an important ingredient, without it, hair will turn gray at a fast rate. Regularly drink milk and eat dairy products to provide optimal nutrition for your hair.

Ugly melasma appears on the skin of the face Illustration. There are many causes of skin pigmentation, some of the main causes are listed below. – Pigmentation disorders: Melasma often occurs due to hyperpigmentation, its manifestation is the appearance of brown spots with levels ranging from light to dark, small to large, sporadic or continuous. – Endocrine disorders: often occur during the menstrual cycle or menopause, prolonged stress, pregnancy or taking birth control pills. – Due to the sun: the impact of ultraviolet rays will stimulate the production of melanin pigment and push it up to the surface of the skin to change the color of the skin. – Abuse of cosmetics: cosmetics containing corticosteroids reduce and lose melasma in a short time due to rapid and strong reduction of skin pigmentation, but only after a while, facial pigmentation appears worse than before. – Due to genetic factors. Factors such as lack of sleep, stress, stress, and improper diet are also the causes of melasma. Treat melasma with honey and lemon juice Ingredients: 2 tablespoons of honey, 2 tablespoons of lemon juice Method: Mix honey and lemon juice together. Clean the skin and then apply the solution on the face and keep it for 20 minutes. Finally, when the mask begins to dry, use warm water to wash your face. Repeat 2-3 times a week for best results. Treat melasma with honey and eggs Take only the egg whites and beat them with a whisk. At the same time, slowly add the honey and stir well. Wash your face with warm water, use a brush to apply the mixture on your face, after 20-30 minutes the mask has dried, then rinse with cold water. Do it twice a week, persist for about a month, you will see the effect. You can use this same recipe but replace the egg whites with the yolks. Egg yolk is suitable for dry, sensitive skin, making your skin smoother.