Because of the more frequent mutations of the new coronavirus recently, “is the vaccine still effective?” has become a concern for everyone. If you want to add annual keywords to the new crown virus, then “mutation” is probably not inferior to “popularity.” “Preliminary research results show that my country’s existing vaccines can cope with the variant strains emerging in India.” Shao Yiming, a researcher at the China Centers for Disease Control and a member of the Vaccine R&D Team of the Scientific Research Group, said in an interview a few days ago that the domestic new crown vaccine still has a protective effect. . How can the domestic new crown vaccine be able to deal with the variant strains emerging in India? A reporter from Science and Technology Daily interviewed industry experts on this matter. The virus has changed Can the antibodies raised by the vaccine not drop? Today, when the antibodies in our body encounter the new coronavirus, it is very likely that we will whisper the phrase “you have changed.” In fact, it is difficult to stay the same, because it travels the world and meets different people and even animals. In the latest “Epidemiology Weekly Report” released by the World Health Organization on May 18, 10 variants were “named”, including 4 “needs of concern” that were first discovered in the UK, South Africa, Brazil, and India. The mutated strains also include 6 strains that “need attention” found in the Philippines, France and other places (slightly lower than the strains of concern). The report specifies the location of the virus mutation sequence change in detail. When the virus changes, can the antibodies raised by the vaccine fail to drop? Not necessarily, it depends on where the virus has changed. Most of the mutations of the concerned strains and the concerned strains fall on the key spike protein, which is responsible for allowing the virus to invade the cell. Its mutation may enhance the virus’s infectivity and may also invalidate existing vaccines, especially for the spike protein. Designed vaccine. “Relevant departments have previously shown based on sequence mutation predictions that although the mutation of the Indian strain falls on the spike protein, it may have little impact on the protective effect of the existing vaccine. Of course, this needs further experimental confirmation.” Said Lu Shan, project commissioner and deputy director of the Public Health and Modern Medicine Division of China Biotechnology Development Center, Ministry of Science and Technology. Changes in viral RNA sequence must pass at least three passes to affect the formation of a protein structure, including changes in coding amino acids, changes in protein folding, and changes in protein three-dimensional conformation. Therefore, from the perspective of sequence analysis, protein simulation, neutralization reaction prediction, etc., the mutation of the Indian strain has not reached the level of “cannot be reduced”. In addition, for the mutant strains that emerged in India, relevant departments are also conducting “practical drills” on them with neutralizing antibodies. Previously, similar studies were conducted on the mutant strains discovered for the first time in South Africa. “The Lancet-Microbe” published the results of two Chinese vaccines on April 13th. The 24 serum samples of vaccine subjects were tested for the neutralization activity of live virus, and wild-type virus strain HB02 and the virus strain BJ01 carrying the D614G mutation were used as controls. The results showed that the neutralization ability of the vaccine evoked antibodies was maintained at a percentage. It’s about sixty or seventy. Multi-party attention and continuous tracking of virus changes Shao Yiming said at the meeting that relevant departments and companies are closely following the mutation of the new crown virus. Once there are variant strains that cannot be dealt with by existing vaccines, we will have new vaccines into use. So, what does close tracking mean? If a new vaccine is needed, how quickly can it be developed? “Vaccine research and development teams continue to pay attention to virus mutations and carry out research and development of new vaccines based on virus mutations.” Lu Shan introduced, for example, the Academy of Military Sciences, Chinese Academy of Sciences, and related companies have gradually carried out. “The eighth edition of the prevention and control plan requires genetic sequencing of all imported cases and the first or early cases in the local epidemic.” Wu Liangyou, deputy director of the National Health Commission’s Disease Control Bureau, said at a press conference earlier that through gene sequencing dynamics Monitoring virus mutations can provide a scientific basis for subsequent studies on the impact of virus mutations on pathogen detection and vaccine protection. Source: Visual China These sequence information will be aggregated to the National Bioinformation Center (National Genome Science Data Center), the new coronavirus information database released by the center, which will continue to track virus mutations. The Chinese Center for Disease Control and other units continue to track the sequence changes of the new coronavirus and conduct in-depth virus mutation analysis. In addition to continuous gene sequencing and analysis for continuous tracking, vaccine research and development companies and research institutes will also conduct dynamic cross-protection experiments on newly emerging mutant strains. The above-mentioned “Lancet-Microorganism” published research is one of the typical studies of various units concerned about the strength of vaccines and viruses. For newly mutated strains, inactivated vaccines have a very quick way to deal with them. Shao Yiming introduced that as long as the virus of the new mutant strain is added to the feeding end, the entire production process does not need to be changed, and a new vaccine against the mutation can be produced. A reporter from Science and Technology Daily also contacted relevant units. In response, Dr. Hangwen Li, the founder of Sri Lanka Microbiology, said that the iterative vaccine development for mutant strains was carried out earlier. The serum produced in animal experiments can be tested by relevant national institutions to have a good neutralizing effect on the new coronavirus mutant strains of concern to the World Health Organization. At present, the iterative vaccine is improving related research applications to carry out a phase 1 clinical trial. Academician Zhong Nanshan judged in an interview not long ago: Due to the mutation of the virus, the new crown vaccine may be given regularly in the future like influenza prevention. So in response to mutations, the new crown vaccine may also be similar to the flu vaccine. After continuous research and development by the R&D team, several vaccines against variant strains of the new coronavirus have been produced, and the corresponding vaccines have been vaccinated. Source: Science and Technology Daily

More than half of adults in New York have had at least one dose of the vaccine. The number of Covid-19 cases and hospitalizations is plummeting. Museums reopen at 50% capacity, cinemas at 33%. Finally, people can sit at the bar to enjoy their favorite drink. The subway will operate 24/7 from May 17, New York Governor Andrew Cuomo said. Parks and outdoor areas get crowded. People are starting to take off their masks in public according to the guidelines of the US Centers for Disease Control (CDC). Rent seems to be stabilizing again. More and more tourists are booking outings. Mayor Bill de Blasio expects 80,000 workers to return to the office on May 4 and has set a target for the city to fully reopen by July 1. “We see a promising return. It feels great,” he said. People enjoy the warm weather in Central Park in New York. Photo: Ed Jones/AP. Optimism about the future While thousands of New Yorkers are suffering long-term health and economic impacts, and most offices are still empty due to the epidemic, things are returning to normal. This makes people optimistic about the future of the city – which suffered the hardest and earliest battle with Covid-19 in the US. After several months of scarcity and difficulty booking vaccination appointments, it is now easy for anyone to do so. By far, it’s the fun things that come back the fastest and most powerful. Over the past few months, Christina Hansen (40), a New York City coach driver for the past nine years, has picked up tourists from California, Texas, Florida and North Carolina. “There is still less work than before, but we are fine. New York is not dead and will never be dead,” Hansen said. MacDougal Street, with its many restaurants and bars in New York, is once again bustling with people. Christina Hansen (right) is delighted to welcome guests back. Photo: Paul Frangipane/Bloomberg. Tickets to next week’s Frieze New York Art Fair, which will bring together collectors from across the United States, are almost sold out. At the Reservoir bar and restaurant in Greenwich Village, locals have to wait about 30 minutes for a table. This place reopened in February, after being closed for almost a year. Another key factor to New York’s return is tourism. The city expects domestic tourism to recover in 2023. Total visitors will surpass the pre-pandemic level of 66.6 million/year by 2024. Devin Cooper (25 years old, living in Los Angeles) immediately booked a flight to New York when he learned that his company allowed employees to travel without being quarantined. He plans to come here in mid-May, when vaccinations are more complete. While it may not be possible to experience some of the city’s famous activities, Cooper says there’s still a lot to see and do. “New York doesn’t seem to have died. This time, I can’t watch Broadway shows and dine outside of restaurants, but it’s a small price to pay for safety during the pandemic,” he said. Slowly recovering Even as most of the art, dining and entertainment life that characterizes New York reopens, the future of work culture, as well as the fate of millions of square feet of office space, remains uncertain. . The subways are far from full, although they will reopen 24/7 hours from May 17, NBC New York news. Mayor Bill de Blasio said office workers would be “a key indicator” of New York City’s long-term return. Some are slowly returning to the workplace. New York will allow offices to increase capacity from 50% to 75% from May 15. Mohammad Naveed, 47, runs a coffee cart near Wall Street. This used to be a prime location that helped him sell about 500 cups of coffee a day. Now, he only sells about 30 cups. “This place is deserted, there are no people,” Naveed explained. During the pandemic, one store after another seemed to be empty. The sector is recovering fast, but it is still far behind. However, between May 2020 and February 2021, 67% of retail jobs, including restaurants, returned to New York state, according to the New York state executive’s office. Coffee carts near Wall Street struggled as offices closed. Photo: Paul Frangipane/Bloomberg. In the real estate sector, the rental market in the Manhattan area shows an early stage of recovery. According to real estate data firm UrbanDigs, new active listings have dropped, monthly leases are increasing, and prices appear to have bottomed out. The number of apartments for rent in New York City is more than double what it was before the pandemic, while maintaining low prices, data from real estate firm StreetEasy shows. StreetEasy economist Nancy Wu said: “The increase in remote work has changed the minds of many renters. Instead of seriously looking for apartments in Manhattan with a short drive to the office, they can afford to explore a host of other neighborhoods in boroughs that might not have been considered before.” Donovan Davis, 24, of Staten Island, waited in line in front of the Supreme store on Bowery Street for about 15 minutes to view the new spring collection and purchase the backpack. Davis was recently vaccinated. Stuck at home for the past year, he didn’t really want to shop until now. “The weather is warming up. I finally started going out and shopping.” Donovan Davis outside the Supreme store in New York on April 30. He only goes out shopping when he is vaccinated. Photo: Misyrlena Egkolfopoulou/Bloomberg. New Yorkers used to not appreciate the crowdedness of the city. The subway isn’t as busy as it used to be. But David felt the city was still alive and slowly returning to normal. “Every time I go out, it’s nice to see that there are still so many people there,” he said.

“I agree that vulnerable people want to wear masks as a precaution, but that’s their own choice,” Andrew said. When someone asked why he didn’t wear them when he went to public places such as supermarkets, subways, he lied, “I am exempt from wearing masks”. Many men refuse to wear masks because they consider it a sign of lack of masculinity and weakness. Photo: Cottonbro / Pexels. According to the The Independent Wearing a mask is the most important method to prevent the virus from spreading. The World Health Organization has been urging people to wear masks since June 2020, a scientific review published in July of the same year in the Journal of the American Medical Association described it as “an important important” in the fight against Covid-19. However, the disturbing fact is that there is a large number of people who refuse to wear masks like Andrew, the majority of which are men. A survey of 2,459 people in the US conducted by two academics at Middlesex University (London) and the University of Berkeley (California, USA) in May 2020 found that men are not only less likely to wear masks in public places. women, many of whom even consider wearing them “embarrassing, uncomfortable and a sign of weakness”. “Wearing a mask is a sign of weakness” Even when he tested positive for Covid-19 and had to be hospitalized, former US President Donald Trump still wanted to show that he did not need a mask, he took it off while standing on the steps of the White House after returning from the hospital. institute. “I don’t wear a mask like him. Standing a few dozen meters away, he was still wearing the biggest mask I’ve ever seen,” Trump said of President Joe Biden during the September 2020 debate. Trump seems to be implying that not wearing a mask means he is showing overwhelming strength against his opponent. Many men believe that only vulnerable people need to wear masks. Photo: Rex Features. A study conducted by the Kaiser Family Foundation, an American NGO that focuses on public health issues, found that 68% of women regularly wear masks when leaving the house, this number in men is 49%. Emma Lygnerud Boberg, gender and program development consultant at International Media Support (Denmark), said: “This is a trend that we have seen before, where men appear to be reluctant to adopt measures. preventive measures than women”. She further notes that this is also consistent with other data, like men wearing seat belts less often than women. Peter Glick, an expert at Lawrence University in Wisconsin, says that men seem willing to take greater risks in everyday life, and that there are toxic gender stereotypes that force men to flex their muscles and fear. hurt. “Men are socialized to be dominant and independent. All these characteristics are intended to reinforce patriarchal norms that present masculinity as a performance. Wearing a mask can be interpreted as It shows weakness in some men. It shows that they are openly afraid of this virus, which means breaking courage,” he told The Independent. Toxic gender stereotypes Preliminary research by James Mahalik, Boston College professor of Developmental Educational Psychology, and doctoral fellows Michael Di Bianca and Michael Harris suggests that individualist tendencies and skepticism toward science Education can be directly related to whether or not a person will accept wearing a mask. To find out why some men refused to wear masks, Mahalik surveyed 596 men across 49 states, of various ages, with incomes ranging from less than $10,000 a year to more than $200,000 a year. The survey asked each person to rate whether they identified certain masculinity standards and to express their thoughts on the Centers for Disease Control and Prevention (CDC) recommendations to minimize sexual harassment. spread of Covid-19. Toxic gender stereotypes are part of the reason some men don’t want to wear masks. In general, respondents felt positive about the Covid-19 prevention guidelines and said they adhered to them (since this was self-provided data, the researchers could not confirm that they actually wear masks all the time). Men who hold negative views on public health recommendations, such as social distancing and wearing face masks, also have traditional masculinity ideals revolving around emotional control, self-reliance, unity, and self-reliance. dominance, victory, power over women, and heterosexual self-expression. “We found that media masculinity saw less benefit from following CDC guidelines. They see more barriers, less trust in science, and they have less empathy for vulnerable or high-risk people,” Mahalik told Fast Company. Instead of trying to convince masculine men to change core elements of their identities, public health officials might consider reducing individualism in men by focusing on more socially friendly aspects of traditional masculinity.

A new graveyard filled with a new grave of Covid-19 victim in Manaus, Brazil. Photo: Sky News. More than 1.5 years since the attack of Covid-19, the world is now witnessing two opposing scenes. In some countries, such as the UK and the US, many people, after being vaccinated, happily hug their loved ones after a long separation. In India, Brazil, and most of South America, thousands of people desperately count down their time, suffering families watching their loved ones leave. Subjectivity is the biggest reason According to Dr. William Schaffner, an advisor to the US Centers for Disease Control and Prevention (CDC), although the pandemic has been around for nearly 1.5 years and the world has made every effort to repel the epidemic, Covid- 19 is still a big challenge. Mr. Schaffner told Zing There are 4 main causes for this condition. The first is the increasing emergence of new strains, which are able to spread more easily and quickly. Next, the health systems in many countries are weak or insufficient to care for and cure patients. The next reason is inadequate vaccine supplies. The ultimate cause lies in how each government responds to the epidemic, and the consciousness of its people. However, he said that the main reason why the epidemic in many places not only did not settle down, but also progressed more complicatedly, was the carelessness of people. “Subjectivity is the biggest reason for the current viral spread in most countries around the world,” Dr. Schaffner said. Zing . Professor Andrew Easton, University of Warwick, UK also agrees. “We are usually quite vigilant for a period of time, then we are distracted, subjective and relaxed, especially when there is nothing serious,” he said. Dr. William Schaffner, longtime advisor to the US Centers for Disease Control and Prevention (CDC). Photo: Vanderbilt University. Italy is the first country to suffer from a pandemic in Europe, with the first Covid-19 wave coming in March 2020. Despite heavy economic and human losses, the country quickly managed to control the epidemic and was hailed as a model for international learning. The ban was quickly lifted or eased in many places. The beaches, cafes, nightclubs, and dance floors get crowded. A lot of people do not wear masks regardless of whether they are on the street or at these venues. By November 2020, the number of infections in this country began to increase sharply. At one point Italy overtook England to become the country with the highest number of deaths because of Covid-19 in Europe. By the end of 5/5, Italy had recorded a total of over 4.06 million cases of Covid-19, of which over 122,000 deaths, according to data from Johns Hopkins University (JHU), USA. In Brazil, during the pandemic, President Jair Bolsonaro always underestimated the severity of the virus. He regularly calls for the lifting of restrictions and blockade orders, despite the country’s steadily increasing number of new infections and deaths. Peru, Mexico, and many other Latin American countries have a similar scenario: outbreaks – control – ban bans are lifted and people gather – more serious outbreaks. India is emerging as the most serious epidemic in the world today. Just three months ago, Indian leaders were happy to announce they had weathered the worst of the pandemic. Prime Minister Narendra Modi even declared the defeat of Covid-19, asserting that it is difficult for any country to match India’s success. At the end of March, the government allowed millions of Hindus to participate in this great religious festival. Social distancing measures are rarely implemented and very few people wear masks. In early April, millions of people also went to the Ganges to perform Hindu prayer rituals. Dr Vineeta Bal, an immune system researcher at the Indian Institute for Scientific Research and Education in Pune, commented that India’s current situation is due to “management failure, failure in planning. guesswork, failure in planning, with that is the thought that has conquered the virus “. India’s biggest religious festival in late March and early April is believed to be one of the causes of the current Covid-19 crisis in the country. Photo: Reuters. The race does not stop Reply to your interview Zing Dr. Schaffner agrees that the race between vaccines and viruses is unlikely to be over. “Viruses will not disappear. We will probably have to deal with it for many years to come. Like the flu, Covid-19 will live with us and we will have to deal with them, ”he said. With a good start, vaccines have given the world a lot of hope in quickly fighting a pandemic. However, in parallel with the vaccine development, new strains of the dangerous and “wiser” SARS-CoV-2 virus began to appear everywhere. Most notably, strain B.1.1.7 was first discovered in the UK and strain P.1 in Brazil. They are both believed to spread faster, and are already present in dozens of other countries around the world. Even the P.1 strain in Brazil is thought to be able to “elude” antibodies from the vaccine and potentially cause reinfection. The number of people dying from Covid-19 is constantly increasing, Brazil has to dig up the old grave to make room for the victim of Covid-19. Photo: AP. Variant B.1.617 in India has appeared in at least 17 countries and regions. This strain has the double mutation; of which, one mutation makes the virus more contagious, and the other makes it partially resistant to the vaccine. “Variants of the SARS-CoV-2 virus present serious challenges against Covid-19. More and more new strains emerge, capable of spreading more quickly and easily, causing rapid and widespread outbreaks, “said Dr. Schaffner. Zing . So far, as observed by Dr. Schaffner, current vaccines appear to be fully or partially effective against new strains. “However, if more new strains arise, they (mutants) are very likely to resist the current vaccine. Then we will need a new vaccine again,” said Dr. Schaffner. India’s temporary crematoriums burn around the clock because the death toll is so great. Photo: New York Times. Scientists are now working on production of second-generation vaccines that target current strains, he said. They are ready to use when needed. However, he warns that researching the new vaccine will be a long-term and ongoing job. “We will have to keep strain detection systems up and running. We will probably have to constantly make new vaccines, and people will have to get re-vaccinated each year to deal with new strains of the virus, ”Dr. Schaffner told Zing . A nation’s perils are the perils of the world According to Dr. Schaffner, people live in a connected world. Thus, a new strain threatens every country everywhere. “That is why the global need to join hands to overcome this pandemic,” said Dr. Schaffner. By the end of January 2021, the strain was first discovered in the UK, present in more than 70 countries and territories. These numbers with the strain in South Africa and the strain in Brazil are 31 and 37, respectively, according to the World Health Organization (WHO). This suggests that new strains of the virus, wherever they first appear, could quickly invade the rest of the world, threatening global health security. “Every country should anticipate major out-of-control outbreaks,” said Dr. Ashish Jha, Dean of the Department of Public Health at Brown University. Countries like the UK and the US are doing a very good job of vaccination. However, that also only deal with the current strains “. However, Dr. Schaffner said that the greatest hope now in dealing with the immediate pandemic is to distribute the vaccine in a balanced and efficient way around the world. “All countries need to work together to try if they want to succeed”, Mr. Schaffner stressed. The chaplain’s account of the funeral for 150 Covid-19 patients before cremation Every day, Hindu cleric RamKaran Mishra performs a funeral for about 150 people who have died of Covid-19 at the Ghazipur crematory facility east of New Delhi, India.

Laboratory – Center for high-tech medical diagnosis Thien Nhan Danang has enough capacity to confirm positive for Sars-CoV-2. Today, April 26, Dr. Do Thai Hung, Director of Nha Trang Pasteur Institute signed Decision No. 905 / QD-IPN on recognition of the laboratory – Center for high-tech medical diagnosis Thien Nhan Da Nang. confirmation of SARS-CoV-2 virus positive cases. This laboratory is responsible for confirming cases of positive for SARS-CoV-2 virus in Da Nang, to confirm for other localities upon request and report test data according to regulations. . Earlier on April 24, Nha Trang Pasteur Institute conducted an inspection and assessment of the testing capacity for SARS-CoV-2 virus of Thien Nhan Laboratory – Thien Nhan, Thien Nhan High-tech Medical Diagnostic Center in Da Nang. . Thien Nhan Da Nang High-Tech Medical Diagnostic Center has built a molecular biology laboratory according to international association standards, ensuring accuracy and safety in the process of receiving and manipulating tests. Sample / Solution Transport … Nha Trang Pasteur Institute has verified and recognized all the operating documents / procedures, equipment management, initial waste treatment in medical waste treatment, general testing procedures. test; fully equipped with chemicals, biologicals and materials for the SARS-CoV-2 confirmation test. In particular, people who test positive cases for SARS-CoV-2 virus meet the prescribed requirements, are well trained in screening testing techniques trained by Nha Trang Pasteur Institute. According to Mr. Ngo Duc Hai, Director of Thien Nhan High-tech Medical Diagnostic Center, is the first private medical unit in Da Nang to be licensed by the Department of Health of Da Nang City to coordinate the City Disease Control Center. Da Nang (CDC) tested for SARS-CoV-2 from August 2020. Over the past time, Thien Nhan laboratory has tested SARS-CoV-2 for more than 8,000 people, actively serving the Covid-19 epidemic prevention and control of Da Nang city and central provinces. Especially during the peak epidemic in Da Nang 8-2020, to meet the needs of safety in production, travel, exit … in accordance with regulations on prevention and control of Covid-19 epidemic. Thien Nhan hopes to contribute more to the proactively coping with the increasingly complicated Covid-19 epidemic in the world, serving the safety of production, travel, study and work of the people. local at home and abroad.

250 front-line medical staff of Can Tho Central General Hospital were vaccinated against Covid-19 in phase 1 At the injection site, in order to ensure the safety of vaccination, the hospital has arranged all parts and facilities from pre-injection screening, injection area, post-injection monitoring room and first aid facilities. necessary. The hospital is fully equipped with one-way facilities, ensuring 5K, emergency manpower by a team of doctors and nurses, Department of Active Rehabilitation – Anti-poison regularly during the vaccination. ensure emergency management for cases with post-injection reactions during vaccination. Health workers (HCWs) are instructed to complete information disclosure procedures to help ensure safety in pre-vaccination screening. The stage of vaccination is done by staff specializing in vaccination practice. The immunization officer also gives detailed instructions about abnormalities that need to return or immediately go to the nearest medical facility for treatment. Health-care workers are monitored in the follow-up room 30 minutes after vaccination, to promptly handle immediate reactions occurring after vaccination. If there are no abnormal symptoms, the health worker will be issued a certificate of vaccination against Covid-19 and continue to monitor the health for updates according to regulations of the Ministry of Health. 100 frontline health workers in Bac Lieu were also vaccinated against Covid-19 in phase 1 In Bac Lieu, Bac Lieu General Hospital also organized AstraZeneca vaccination for Covid-19 prevention phase 1 for 100 people who are the frontline medical team.

“This tuning is better for the current, unpredictable and ever-evolving threat of Covid-19. We continue to recommend that US citizens reconsider traveling abroad and postpone trips if possible, ”the ministry wrote in an email. In a media statement, the agency said the change does not “imply an assessment of the current health situation in a particular country”, but rather an advice for US citizens, in addition to information from the US Centers for Disease Control and Prevention (CDC). America warns people not to move to 80% of the countries of the world. Photo: Reuters. In addition to reflecting on travel health notices issued by the CDC, US State Department advisers are looking at logistical factors, such as travel restrictions for US citizens. If the passenger decides to go to the countries with a level 4 warning, the State Department recommends that they carefully read the information about the risks of arrival. The warning comes as the number of US passengers continues to increase and many countries around the world begin to open their borders to Americans. On April 19, Greece started to allow US citizens to re-enter if they have a negative test certificate for the virus or have been vaccinated. United Airlines has also announced new flights to Greece, Iceland and Croatia, starting in July. Earlier this month, the CDC said fully vaccinated people could move, and the risk this group poses is quite low. Even so, the agency said it still discourages movement as the number of new Covid-19 infections is still increasing in the US and globally. On its website, the agency recommends that residents postpone international trips until everyone is fully vaccinated. The agency warned: “Passengers who are fully vaccinated are less likely to become infected and spread Covid-19. However, international migration is still potentially risky and even fully immunized people are at risk of catching new virus strains and spreading them to the community ”.

CDC Can Tho receives vaccines. Photo: VNA broadcast Accordingly, the vaccine has been safely transported by the Pasteur Institute of Ho Chi Minh City to the Center for Disease Control in Can Tho City. Immediately after receipt, all of these vaccines were stored in cold storage by the unit and stored in accordance with regulations, as well as recommendations of the manufacturer. The system of cold chain for storing vaccines of the Center for Disease Control in Can Tho city today, including: refrigerators, specialized cold boxes, vaccine thermos bottles, automatic temperature monitoring devices … meet the standards. about vaccine preservation. Recently, the unit also received 4 additional dedicated vaccine storage cabinets TCW 4000 AC, each with a storage capacity of about 60,000 doses of AstraZeneca vaccine. The room COVID-19 AstraZeneca vaccine was researched and developed by Oxford University and the World Health Organization through approval for emergency vaccines on February 15. Updated to March 8, the vaccine has been used in 98 countries around the world. In Vietnam, the COVID-19 AstraZeneca vaccine has been conditionally approved by the Ministry of Health as a vaccine for urgent needs in the prevention and control of COVID-19 in Decision No. 983 / QD-BYT dated 1/2/2021. CDC Can Tho receives vaccines. Photo: VNA broadcast AstraZeneca vaccine is bottled in 10 doses / vial, 100 vials / box, stored at 2-8 degrees Celsius and not frozen. This vaccine is indicated for vaccination against people 18 years of age and older; Intramuscular injection, dose of 0.5ml. 2 doses of 2 doses are recommended, each 12 weeks apart. In 2 days, April 19-20, at the Center for Disease Control in Can Tho City (CDC Can Tho), the competent forces will pre-inject some people with the participation in monitoring and sharing experiences. of the Pasteur Institute of Ho Chi Minh City. On the basis of learning from experience, the forces will deploy simultaneous injections at fixed injection points in the city on April 22-24, including: 7 hospitals, City Center for Disease Control Can Tho and 9 district health centers. Priority subjects who have not yet been vaccinated will receive additional injections from April 27-29. The Center for Disease Control in Can Tho city notes that vaccinated people strictly follow the instructions of the Ministry of Health to ensure safety in vaccination against COVID-19. CDC Can Tho receives vaccines. Photo: VNA broadcast * Tuyen Quang province has received 4,500 doses of AstraZeneca vaccine for COVID-19 room from the National Institute of Hygiene and Epidemiology. These vaccines were transferred to the Center for Disease Control of Tuyen Quang province and stored in a cold chain system, at a temperature of 2-8 degrees Celsius. It is expected that all 4,500 doses of vaccine will be given priority to vaccinate phase 1 for free for those who are frontline anti-epidemic forces: People working in health facilities; people involved in epidemic prevention; army and police force. Mr. La Dang Re, Deputy Director of the Department of Health of Tuyen Quang province, said that the Department organized a training course for medical units in the province on COVID-19 vaccination; plan to organize 2 injections. In particular, the first phase injected about 1,000 doses at 3 points, which are Tuyen Quang Provincial General Hospital, Provincial Public Security Hospital and Phuong Bac Hospital. In order to prepare well for the vaccination work in the area, the provincial health sector has prepared manpower and equipment, ensuring that all injection sites are strictly arranged according to one-way regulations. Those who are vaccinated will be screened before first vaccination, monitored 30 minutes after injection, followed by 7 days to ensure safety. The Department of Health of Tuyen Quang province has directed the units to urgently make a list of priority subjects; organizing training courses, guiding the reception, use, preservation of COVID-19 vaccines and monitoring of post-injection adverse events; prepare sufficient human resources and equipment to meet the situations before deploying vaccination. From April 19, the functional forces will deploy vaccination in Tuyen Quang city; early May 2021 will be vaccinated in the districts of the province.

U.S. halts use of Johnson / Johnson vaccine

The implementation of johnson&johnson’s (J&J)one-dose Covid-19 vaccine was halted on April 13 when regulators announced they were reviewing rare cases of blood clots after receiving it. The move could prompt thousands of people expected to get the J&J vaccine this week to find an alternative.

The Food and Drug Administration (FDA) and the U.S. Centers for Disease Control and Prevention (CDC) both recommend halting the distribution of the J&J vaccine after recording 6 cases of cerebral vein sinus thrombosis (CVST).

Illustration: Reuters

Symptoms are noted in women between the ages of 18-48 and appear 6-13 days after the J&J. vaccine injection. “Among cases of coaalysis in the U.S., one person has died and one patient is in critical condition,” said Peter Marks, head of the FDA’s Center for Biological Research and Evaluation.

However, stopping the use of the J&J vaccine in the US when there are only a few cases of blood clots has raised questions about over-reactions.

Speaking at the White House on April 13, Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases, said that the CDC and FDA have acted “with extreme caution” and stressed that the decision to recommend stopping the use of the J&J vaccine is only temporary.

“I don’t think they made the decision in a hurry,” Mr. Fauci said.

Despite this, the move left those planning to get the J&J vaccine confused and raised concerns that it could cause hesitation over covid-19 vaccination.

Earlier, 15 million J&J vaccines were damaged due to production errors at a factory. In Colorado, three mass vaccination points stopped using the J&J vaccine last week after 11 people reported symptoms of nausea and dizziness after receiving the vaccine.

For regulators, halting the use of the J&J vaccine has made it difficult to meet the urgent need for vaccines during the pandemic. When investigating the issue, U.S. officials must also try to maintain public confidence in the vaccination program. The suspension of J&J vaccination shows that regulators are taking potential issues seriously, but if they can’t find an answer yet, it could make people more concerned about vaccinations.

Link between J&J vaccine and cerebral vein sinus thrombosis

Cerebral vein sinus thrombosis (CVST) is a condition in which blood clots are formed in the veins and sinuses of the brain. This is a rare form of a stroke. In the general population, this symptom occurs in about 5 out of 1 million people. Symptoms of CVST include headache, blurred vision, convulsions, and loss of body control.

However, there are a number of factors that cause regulators to pay attention to cases of CVST after a single dose of J&J. Mr. Marks explained that, patients with blood clots also have tinglet reduction, the condition of tinglets in the blood decreases to very low levels, leading to bleeding and bruising. The combination of blood clots and low tinglets prevents patients from using common anti-coaculation treatments such as heparin, a blood thinner. That’s why health officials want to halt J&J.J. vaccinations until concerns can be investigated and give new guidance if necessary.

In addition, another factor is the cases of blood clots that occur in young women, who usually do not face a high risk of suffering from this disease.

The suspension of the J&J vaccine has been reminiscent of many European countries suspending all or part of the Covid-19 AstraZeneca vaccination program due to fears of blood clots. In March, the European Medicines Regulator (EMA) halted distribution of the AstraZeneca vaccine before allowing it to continue. Later, regulators concluded the AstraZeneca vaccine did not increase the risk of blood clots.

“This is a safe and effective vaccine. The benefits of vaccines in protecting people from the risk of dying and hospitalization from Covid-19 are far greater than the possible risks,” EMA Executive Director Emer Cooke said at a press conference in March.

Both the AstraZeneca vaccine and the Johnson /Johnson vaccine are based on modified adenovirus vectors. Adenovirus is a separate virus designed to provide DNA instructions to cellsto make the mutable protein of SARS-CoV-2, the virus that causes Covid-19.

Nearly 7 million people in the U.S. who have been vaccinated with the J&J. Vaccine AstraZeneca are still under review and have not yet begun distribution in the U.S., even though the country’s government has purchased millions of doses of the vaccine.

The link between the J&J vaccine and symptoms of cerebral vein sinus thrombosis has not yet been clarified, but Vox has made several assumptions.

“Mutant proteins are produced using instructions from vaccines,” said Robert Brodsky, Director of hematological division at Johns Hopkins University. In some cases, mutating proteins can trigger the response of the immune system. That immune response can also damage the tinglets, causing symptoms such as blood clots.

In addition, if a spike in a protein can trigger this reaction, it is likely that the virus is intact that can also activate CVST in vulnerable people.

Rare complications that create major public health challenges

The Covid-19 vaccine has been tested on tens of thousands of people in clinical trials, and all three licensed vaccines in the U.S., Moderna, Pfizer/BioNTech, and Johnson & Johnson have all been proven safe, with levels of side effects being mild to medium.

Health workers prepare J&j’s Covid-19 vaccine shots in Detroit on April 12. Photo: AP

But as the number of people taking part in vaccine trials increased from thousands to millions, rare complications began to appear.

That happened to Pfizer/BioNTech after the vaccine was distributed to the market. Some people after vaccination experience a severe allergic reaction to the Pfizer vaccine. Similar problems also appeared with the Moderna vaccine. In January, the CDC estimated that the rate of allergic reactions to the Pfizer/BioNTech vaccine was 11.1 per 1 million vaccinations, while the rate of the Moderna vaccine was 2.5 per 1 million vaccinations.

Health officials have revised the vaccination process to screen people with a history of severe allergies. They also asked the person after vaccination to stay for 15 minutes for monitoring, as most allergic reactions occur during that time period.

Regulators can add screening criteria for people at higher risk for blood clots before getting the J&J vaccine.

It’s too early to say whether regulators will do the right thing when it comes to halting J&J vaccinations. Studying potential vaccine issues can boost people’s confidence in vaccinations, but can also cause confusion and fear of complications, making more people more vigilant.

What about those who have received the J&J vaccine?

Dr Fauci said that, for those who had received the J&J vaccine more than a month ago, they didn’t need to worry. However, those who have recently received the J&J vaccine and begin to have symptoms associated with cerebral sinus thrombosis should inform their doctor. “6-13 days after vaccination will be the time of symptoms,” Mr Fauci said.