Author丨Fengse Fish and Sheep

Collected all the new crown machine learning “watch movies” papers, Nothing works for one article ? !

Just as the news that “two medical staff in Guangzhou tested positive for nucleic acid” once again affected the nerves of the big guys, a new study from the University of Cambridge also ignited a barrel of explosives on the Internet.

Since the beginning of the epidemic, many researchers in the field of machine learning hope to use the power of AI to help medical staff better protect themselves:

From January to October last year, more than 2,000 related papers were published.However, just when AI is more mature Watch a movie Field, Cambridge University’s conclusions are surprising:

The collected papers on the use of AI for medical image detection and diagnosis of the new coronavirus have major flaws and deviations, and there is no possibility of clinical use. The collected papers on the use of AI for medical image detection and diagnosis of the new coronavirus have major flaws and deviations, and there is no possibility of clinical use. The paper has been published on Nature Machine Intelligence. And such “cruel” results can be said to have stirred up waves with one stone. Experts and scholars have reposted the discussion, and it has also triggered heated discussions among netizens on social media. Many relevant practitioners said: “This has taught us an important lesson.” What is going on? Why can’t it be used? Specifically, the researchers at the University of Cambridge initially used the “machine learning model” and “CXR models” in the preprinted paper platforms such as bioRxiv, medRxiv, and arXiv, as well as the EMBASE and MEDLINE databases.(Chest X-ray photo)/CT image diagnosis, prediction” such keywords, collected 2212 Related studies. After excluding papers that lack external verification, ignoring data sources, or incomplete model training information, the papers that passed the preliminary screening were: 415 articles . And to further improve the requirements for papers, such as excluding RQS(Radioactive quality score)＜6, failed to pass CLAIM(Medical imaging artificial intelligence checklist)After the model, the papers selected for the final review stage are 62 Stories . And these 62 articles, Have no potential clinical application value . In response, one of the authors of the paper, Dr. James Rude from the University of Cambridge School of Medicine, said: The international machine learning community has made tremendous efforts to help respond to the Covid-19 epidemic. These early studies gave us some hope, but their method and reporting deficiencies are very common. None of the papers we reviewed achieved the robustness and repeatability necessary to support clinical applications. The international machine learning community has made tremendous efforts to help respond to the Covid-19 epidemic. These early studies gave us some hope, but their method and reporting deficiencies are very common. None of the papers we reviewed achieved the robustness and repeatability necessary to support clinical applications. Of the 62 papers, 55 were found to be at high risk of bias due to various problems, including relying on public data sets, many of which were suspected of being positive for Covid-19 and were not detected in CT images. △ Data indicators for each paper All of these models appear to be highly accurate in the study, and they are fully revealed as soon as they arrive in the clinic (for example, different types of patients or imaging scans obtained with different equipment). Behind this “annihilation” is mainly the problem of data sets. Many of these models are trained with very small sample data sets, and some data only come from one hospital. If you change a city to a hospital, this model will not work at all. There are also models that are trained based on the publicly available “Frankenstei Data Set”. The problem with such a large data set is that as time goes by, the data set continues to develop and incorporate new data. These changes are likely to make the original results impossible to reproduce. What’s more, the same data set is used for training and testing. Of course, this may not be deliberately done by researchers. For legal and commercial reasons, many medical data sets have to be Keep secret , There are really few large and diverse data for researchers to train and verify. This also makes the machine learning research produced in the health care field particularly difficult to replicate. MIT has done a study: The recurrence rate of medical AI papers is only 23%, compared with 58% in the field of natural language processing and 80% in the field of computer vision. But the data set is only one aspect. There are also problems with improper method design and lack of participation of radiologists and clinicians. For example, a training set with a model uses CT images of children as “non-Covid-19” data, and adults as “Covid-19” data. But in fact, children treated in pediatrics are very different from adults in terms of human anatomy. Such data settings are unreasonable, and the trained model will have large deviations. “Whether you are using machine learning to predict the weather or detect diseases, it is important to ensure that different experts work together and speak the same language so that you can focus on the right issues.” Unfortunately, many models do not allow radiology departments. Doctors and clinicians get involved. In addition, time limit It can also be interpreted as an “excus” for this series of questions. “These obstacles must be overcome, Otherwise, we will face a crisis of trust” Of course, behind the fact that a large number of such papers are published but all cannot be applied, it shows that the paper a There are also problems, such as the lack of in-depth understanding of machine learning by the reviewers, or blind trust in well-known institutions or companies, etc., which led to these papers being passed hastily. But the most important thing is the lack of review institutions Consistent standards To evaluate machine learning research in the medical field. Researchers at the University of Cambridge believe that a common set of standards must be established between authors and reviewers to ensure that the research really solves practical problems. Finally, although a large number of Covid-19 models have been found to be unable to be reproduced for clinical use, researchers at the University of Cambridge said that after some key modifications, these machine learning models can still become powerful tools in the fight against the new crown. They gave some conclusions and suggestions:

• Public data set May cause serious risk of deviation, use with caution;
• In order to make the model applicable to different groups and independent external data sets, the training data should be kept Variety and appropriate size ；
• In addition to higher-quality data sets, you also need Reproducible and externally verified In this way, the possibility of the model being promoted and integrated into future clinical trials can be increased.

Public data set May cause serious risk of deviation, use with caution; In order to make the model applicable to different groups and independent external data sets, the training data should be kept Variety and appropriate size ； In addition to higher-quality data sets, you also need Reproducible and externally verified In this way, the possibility of the model being promoted and integrated into future clinical trials can be increased. And said that these obstacles must be overcome, otherwise, where will people’s trust in artificial intelligence start?In addition, due to privacy restrictions, it is difficult to obtain medical data. In addition to federal learning, you can also refer to the latest published on the cover of Nature. Joint learning (Swarm Learning), A medical data sharing technology superior to federal learning. Is it okay for AI to watch movies? Facing the conclusion of the University of Cambridge, some netizens are worried: Today, the value and credibility of AI/ML are being diluted. When I hear words like “AI solution” and “AI driven”, I even feel nervous. Today, the value and credibility of AI/ML are being diluted. When I hear words like “AI solution” and “AI driven”, I even feel nervous. Some netizens believe that this is not unrelated to the current trend of “watering” papers in the field of machine learning. However, some netizens objectively analyzed that AI has indeed played a role in medical imaging, but they can’t replace doctors, they are more acting as doctors. assistant And at present, AI has no way to deal with some really difficult situations. And for what the article talks about data Many netizens agree with the question: Data is not the only problem, but it seems to be the most direct cause. It’s time to build a database like “Protein Bank” for AI models and data sets. Data is not the only problem, but it seems to be the most direct cause. It’s time to build a database like “Protein Bank” for AI models and data sets. In fact, no matter whether you are skeptical about AI medical care or not, now, at least like AI watching movies Such medical services have truly come to the public. Prior to this, colleagues of qubits had asked AI to take a CT scan at Zhongguancun Hospital. In the communication with first-line doctors, the chief doctor in charge of the physical examination center in the tertiary hospital also revealed to us that single-point applications such as the detection of lung nodules have been able to help doctors reduce the burden. There are even radiologists who said, “I don’t use it now (AI assisted viewing), and I’m not used to it.” Stat News commented on this: Machine learning is booming in the medical field, but it is also facing a credibility crisis.

Machine learning is booming in the medical field, but it is also facing a credibility crisis.

So, do you think AI medical care will work?

— Finish —

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Welcome to forward to the circle of friends.

May 11th of the Lunar Calendar

NowadaysLookSummer graduation song at station B

My colleague said it was taken at his alma mater

I miss my student days

While envious of colleagues

So there are so many stars in the school

In the end, he said he was used to it

I have seen many stars come to school in the four years of university

Here are the other big news today

# Sichuan Bitcoin mining farm collectively cuts off power netizens: Nice job

(China Fund News) It is reported that due to policy reasons, China and even Sichuan, the world’s most important gathering place for Bitcoin mining machines, will usher in a large area of ​​mining machines. According to calculations, the shutdown load is about 8 million kilowatts. Following Inner Mongolia and Xinjiang, Sichuan, which is dominated by clean energy and hydropower, also failed to become the last bastion of Bitcoin mining in China.

A document “Notice of the Sichuan Provincial Development and Reform Commission and the Sichuan Provincial Energy Bureau on the Cleanup and Shutdown of Virtual Currency “Mining” Projects” shows that for virtual currency “mining”, relevant power companies in Sichuan need to do so on June 20. The screening, clean-up and shutdown work was completed a few days ago.

According to data from btc.com, the current average computing power of the entire Bitcoin network is 126.83 EH/s, which is nearly 36% lower than the historical high of 197.61 EH/s (May 13). At the same time, Bitcoin mining pools with Chinese backgrounds such as Huobi Pool, Binance, AntPool and Poolin have fallen sharply in their computing power. The decline in computing power in the past 24 hours has been 36.64%, 25.58%, 22.17%, and 8.05%, respectively.

:plus! Big! force! degree!

# The supply chain has received the design proposal of Huawei Mate 50, and the delivery time is to be determined

(House of IT) According to China Securities Journal, Huawei Supply Chain Company stated that they have received Huawei Mate 50 mobile phone design. “Huawei did not say that it will cancel the release, but the time for mass production and supply has not yet been determined.”

At present, Huawei officials have not yet officially responded to the above news. However, some Huawei coefficient code bloggers said that they will not be cancelled, but will be postponed, and will do their best to launch this year.

According to the period of Huawei’s previous release of new products, the P50 series of mobile phones should have been released in March, and the Mate 50 series should be launched in September this year and equipped with a new generation of Huawei’s self-developed chips.

: Tears again.

# Xiaomi’s three new screens broke the news: MIX4 is FHD+ Huaxing screen, and there will be direct screens next year

(House of IT ) Digital blogger @ 数码闲聊站 recently broke a lot of information about new under-screen cameras and new folding screens from various manufacturers. Although some did not clearly indicate that they are Xiaomi, I believe there are still some small partners who can see it.

Although the news is complicated, there are actually three products about Xiaomi. Digital blogger @ ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ release, Mi MIX4 and MIX FOLD will be released this year. , The latter supports 90/120Hz for both internal and external screens, while the third model is a direct-screen model with 1080p + 90Hz refresh rate and will be released next year.

Combined with the news of @数码闲聊站, the MIX FOLD under-screen version will be equipped with Qualcomm Snapdragon 888 chip, with 5000mah battery, and the rear main camera is still 108MP; while Xiaomi MIX4 will use the upgraded version of the Huaxing Optoelectronics under-screen solution shown last year , The hyperboloid AMOLED screen is expected to be around 6.67 inches, or it will support high refresh rates.

: There are so many people looking forward to MIX4.

# my country’s new crown vaccination has more than 1 billion doses, all regions continue to go all out to ensure vaccine supply

(CCTV )The National Health Commission announced today (June 20) that as of June 19, 31 provinces, autonomous regions, municipalities, and Xinjiang Production and Construction Corps had reported a total of 1.010.48 million doses of COVID-19 vaccine.

my country’s new crown vaccination has more than 1 billion doses, and all localities continue to make every effort to ensure the supply of vaccines, increase the organization and implementation of vaccination, and introduce a number of convenient measures to facilitate the people’s vaccination.

At present, all localities are taking effective measures to ensure the smooth progress of vaccination work.

: The second shot is over!

Because of the more frequent mutations of the new coronavirus recently, “is the vaccine still effective?” has become a concern for everyone. If you want to add annual keywords to the new crown virus, then “mutation” is probably not inferior to “popularity.” “Preliminary research results show that my country’s existing vaccines can cope with the variant strains emerging in India.” Shao Yiming, a researcher at the China Centers for Disease Control and a member of the Vaccine R&D Team of the Scientific Research Group, said in an interview a few days ago that the domestic new crown vaccine still has a protective effect. . How can the domestic new crown vaccine be able to deal with the variant strains emerging in India? A reporter from Science and Technology Daily interviewed industry experts on this matter. The virus has changed Can the antibodies raised by the vaccine not drop? Today, when the antibodies in our body encounter the new coronavirus, it is very likely that we will whisper the phrase “you have changed.” In fact, it is difficult to stay the same, because it travels the world and meets different people and even animals. In the latest “Epidemiology Weekly Report” released by the World Health Organization on May 18, 10 variants were “named”, including 4 “needs of concern” that were first discovered in the UK, South Africa, Brazil, and India. The mutated strains also include 6 strains that “need attention” found in the Philippines, France and other places (slightly lower than the strains of concern). The report specifies the location of the virus mutation sequence change in detail. When the virus changes, can the antibodies raised by the vaccine fail to drop? Not necessarily, it depends on where the virus has changed. Most of the mutations of the concerned strains and the concerned strains fall on the key spike protein, which is responsible for allowing the virus to invade the cell. Its mutation may enhance the virus’s infectivity and may also invalidate existing vaccines, especially for the spike protein. Designed vaccine. “Relevant departments have previously shown based on sequence mutation predictions that although the mutation of the Indian strain falls on the spike protein, it may have little impact on the protective effect of the existing vaccine. Of course, this needs further experimental confirmation.” Said Lu Shan, project commissioner and deputy director of the Public Health and Modern Medicine Division of China Biotechnology Development Center, Ministry of Science and Technology. Changes in viral RNA sequence must pass at least three passes to affect the formation of a protein structure, including changes in coding amino acids, changes in protein folding, and changes in protein three-dimensional conformation. Therefore, from the perspective of sequence analysis, protein simulation, neutralization reaction prediction, etc., the mutation of the Indian strain has not reached the level of “cannot be reduced”. In addition, for the mutant strains that emerged in India, relevant departments are also conducting “practical drills” on them with neutralizing antibodies. Previously, similar studies were conducted on the mutant strains discovered for the first time in South Africa. “The Lancet-Microbe” published the results of two Chinese vaccines on April 13th. The 24 serum samples of vaccine subjects were tested for the neutralization activity of live virus, and wild-type virus strain HB02 and the virus strain BJ01 carrying the D614G mutation were used as controls. The results showed that the neutralization ability of the vaccine evoked antibodies was maintained at a percentage. It’s about sixty or seventy. Multi-party attention and continuous tracking of virus changes Shao Yiming said at the meeting that relevant departments and companies are closely following the mutation of the new crown virus. Once there are variant strains that cannot be dealt with by existing vaccines, we will have new vaccines into use. So, what does close tracking mean? If a new vaccine is needed, how quickly can it be developed? “Vaccine research and development teams continue to pay attention to virus mutations and carry out research and development of new vaccines based on virus mutations.” Lu Shan introduced, for example, the Academy of Military Sciences, Chinese Academy of Sciences, and related companies have gradually carried out. “The eighth edition of the prevention and control plan requires genetic sequencing of all imported cases and the first or early cases in the local epidemic.” Wu Liangyou, deputy director of the National Health Commission’s Disease Control Bureau, said at a press conference earlier that through gene sequencing dynamics Monitoring virus mutations can provide a scientific basis for subsequent studies on the impact of virus mutations on pathogen detection and vaccine protection. Source: Visual China These sequence information will be aggregated to the National Bioinformation Center (National Genome Science Data Center), the new coronavirus information database released by the center, which will continue to track virus mutations. The Chinese Center for Disease Control and other units continue to track the sequence changes of the new coronavirus and conduct in-depth virus mutation analysis. In addition to continuous gene sequencing and analysis for continuous tracking, vaccine research and development companies and research institutes will also conduct dynamic cross-protection experiments on newly emerging mutant strains. The above-mentioned “Lancet-Microorganism” published research is one of the typical studies of various units concerned about the strength of vaccines and viruses. For newly mutated strains, inactivated vaccines have a very quick way to deal with them. Shao Yiming introduced that as long as the virus of the new mutant strain is added to the feeding end, the entire production process does not need to be changed, and a new vaccine against the mutation can be produced. A reporter from Science and Technology Daily also contacted relevant units. In response, Dr. Hangwen Li, the founder of Sri Lanka Microbiology, said that the iterative vaccine development for mutant strains was carried out earlier. The serum produced in animal experiments can be tested by relevant national institutions to have a good neutralizing effect on the new coronavirus mutant strains of concern to the World Health Organization. At present, the iterative vaccine is improving related research applications to carry out a phase 1 clinical trial. Academician Zhong Nanshan judged in an interview not long ago: Due to the mutation of the virus, the new crown vaccine may be given regularly in the future like influenza prevention. So in response to mutations, the new crown vaccine may also be similar to the flu vaccine. After continuous research and development by the R&D team, several vaccines against variant strains of the new coronavirus have been produced, and the corresponding vaccines have been vaccinated. Source: Science and Technology Daily

Mexican beauty crowned Miss Universe 2020. Notably, the crown that New Miss Universe 2020 received is worth 5 million USD (equivalent to 115 billion VND). This Miss crown was made by jeweler Mouawad Jewelry. With this price, the Miss Universe 2020 crown becomes the most expensive crown in the history of world beauty pageants. The Miss Universe crown is made of white diamonds. (Photo: Philstarlife) As revealed by jeweler Mouawad, this year’s crown is handcrafted and extremely sophisticated. All stages from design, processing to fabrication are meticulously performed by famous jewelers. Every stage is meticulously crafted. (Photo: Philstarlife) The crown features 1,725 ​​white diamonds and three canary yellow diamonds. In particular, the most prominent is a 62.83 carat yellow canary diamond in the center. In the center of the crown is a 62.83 carat yellow canary diamond. (Photo: Miss Universe) This is the second time Mouawad has been chosen to make the Miss Universe crown. The first crown was for Miss Universe Zozibini Tunzi of South Africa when she won in 2019.

Miss Universe 69th: Miss Mexico Andrea Meza. Miss Mexico Andrea Meza brings to Miss Universe a costume inspired by a traditional craft village of this country called Alebrijje, which is a surrealist craft made of cardboard and paper. or wood. Colorful costumes with bold Mexican spirit. Miss Mexico Andrea Meza is 26 years old this year, she is 1m82 tall. 1st runner-up: Miss Brazil Julia Gama Miss Brazil wears a dress inspired by the cotton fields of her homeland. The outfit received mixed reviews because it showed too much skin. Miss Brazil, Julia Gama, she is 1m77 tall. 2nd runner-up: Miss Peru Janick Maceta Del Castillo Miss Peru Janick Maceta Del Castillo was the last-minute national costume change contestant. The outfit she performed on the official stage of Miss Universe was inspired by the Andes flamingo, the rarest flamingo in the world. Miss Peru, Janick Maceta Del Castillo, she is 1m77 tall. 3rd runner-up: Miss India Adline Castelino. Miss India Adline Castelino with set saree familiar in this country. The national costume has the pink color of the lotus, which is also the national flower of India. The costume is highly appreciated for its simplicity, no frills but true to the spirit of the national costume. In addition, Adline is extremely beautiful, she is praised for appearing like a princess. Miss India Adline Castelino, she is 1m69 tall. 4th runner-up: Miss CH Dominic Kimberly Jimenez. Miss Dominic Kimberly Jimenez in a sunflower-inspired outfit. This is the favorite flower of the Dominican people, grown a lot in the central part of the country. Miss CH Dominic Kimberly Jimenez, she is 1m78 tall.

According to the GMA News Online , it was created by luxury jewelry house Mouawad. The company director said the crown is set with a 62.83 carat yellow canary diamond in the center. Additionally, two included yellow canary diamonds on the sides add extra sparkle. The crown Miss Zozibini Tunzi once wore was handed over to the deserving person. Photo: Miss Universe. “While the central diamond represents power, the two smaller diamonds create a sense of harmony. The intertwined tree motifs represent the diaspora of women from around the world. It reminds us that solidarity makes us stronger than apart,” said director Mouawad. As a famous jewelry house, nothing can make Mouawad difficult. However, the inventor said that the biggest challenge when making this crown was to create the extraordinary, to understand and embrace the values ​​​​of Miss Universe. Accordingly, the person wearing this crown will represent ambition, diversity, community and beauty. Mouawad is a luxury jewelry, watch and accessory company founded in 1891 in Lebanon. David Mouawad is the founder, but the development of the brand worldwide depends on his son – Fayez Mouawad. The crown was invented by Mouawad. Photo: thepeachreview.com

Julia Gama – the beautiful representative of Brazil – is expected to become the new owner of the Miss Universe crown this year. However, she only stopped at the 1st runner-up. She shone in a dress with a bust, high split, and glittering sequins at the finale. Photo: Getty. During the contest, Julia regularly updated her body image. However, the color scheme of the beauties’ costumes often does not receive much support. Photo: Julia Gama. In the early days of her appearance, she always tried to make herself stand out through neon-tone dresses. Photo: Julia Gama. Closer to the finale, Julia is more restrained with neutral outfits. She creates accents with earrings, large bracelets or branded bags. Photo: Julia Gama. Before that, Brazilian beauties were associated with simple everyday clothes. Plain two-piece skirts or tight-fitting jeans are indispensable items, helping to flatter her figure. Photo: Julia Gama. The outfit that emphasizes the healthy features is chosen by Julia for stress-relieving trips. Photo: Julia Gama. Two-piece bikini with outstanding colors such as yellow and red is loved by Julia every summer. Although not sophisticated in design, the designs still ensure to respect the physical advantage of the 27-year-old beauty. Model work helps her gain more confidence when wearing sexy clothes. Photo: Julia Gama.

When Miss Universe Brazil became the 69th Miss Universe 1st runner-up, netizen Looking back at Julia Gama’s battle journey and discovering, she belongs to the group of contestants dressed in super casual. While Miss Thailand Amanda Obdam changed to 5 different outfits on her way to the US, the Brazilian contestant wore only two outfits, both of which were plain colors without textures and simple designs. During the whole competition, Julia Gama often appeared with the set Simple and discreet like this. Even the colors are very basic, not as vibrant as many other competitors. Of course, thanks to her perfect figure, she still stands out. Even when wearing dresses, Julia Gama also chooses designs that do not hug the figure. This blue dress was praised for being beautiful and elegant, but it made her unable to show off her figure. When wearing a neon green tight dress that stood out as a Miss contestant, Julia Gama again wore a closed coat. The other contestants always wear high heels, Julia Gama is not afraid to wear sneakers and a set Simple, healthy clothes like traveling. Some of the other costumes she wore in the contest were just harmonious and beautiful, not as outstanding or gorgeous as the ones that other contestants prepared. Not to mention Julia Gama also especially likes black, although this is a color that rarely appears in Miss contests. But despite having a not-so-great costume store, Julia Gama still scored strongly with the judges and won the 1st runner-up position, just missing a little bit of luck to reach the crown.

On May 20, the organizers of Miss Grand Indonesia announced that Sophia Rogan has become the new Miss, will represent the country at Miss Grand International at the end of this year. The appointment ceremony took place online, with the participation of Ivan Gunawan – Miss Grand Indonesia National Director, and Aurra Kharishma (left) – Miss Grand Indonesia 2020. Sophia Rogan was awarded the crown, the national ribbon and the strong support from the team. Homepage Miss Grand International has also updated her information. As such, Indonesia is one of the countries to announce the earliest representation for next season. Sophia Rogan poses with her predecessor. According to Angelopedia, after Aurra Kharishma’s 3rd runner-up, the Miss Grand Indonesia organizers have set strict standards for height and skills to choose the strongest representative to continue the series of achievements for Indonesia. Published information said that Sophia Rogan is 19 years old, 1.82 m tall with a standard body, the advantage of long legs. She is an Indonesian – English hybrid, so her face is not exactly Asian, still has her own charm for many people to remember and not be confused. Originally a fashion model, Sophia Rogan has a lot of experience in catwalk shows, poses and professional demeanor. Fans praise her for being beautiful in a natural, innocent way, but when she wears make-up, she becomes sharp and seductive. “I want to bring a positive outlook to the modeling profession. I want to be an inspiration. To do that, I constantly work, learn, create and dedicate. I hope to be able to do that soon. recognition is part of a change in the fashion and modeling industry,” Rogan told Angelopedia. The Indonesian beauty describes herself as an extrovert, loves nature, loves to explore different cultures. “Traveling not only soothes the spirit and soul, but also teaches you a lot of life lessons,” Rogan said. With a good foundation and existing strengths, Sophia Rogan is expected to shine in the upcoming competition.

Recently, a scientific study made women bewildered when it was announced that one birth will accelerate the aging process 11 years faster. This aging is studied from within the cell and the research is only done on a certain group of people, but in fact, it can’t be denied that postpartum women tend to have a tendency to lose their beauty, their physique is not as neat as they are. infancy. However, there are still mothers who are outside this rule and the beautiful crown princess of Malaysia – Khaleeda Bustamam is one of them. Khaleeda Bustamam (born 1993) has been married to Tunku Ismail Ibrahim, Crown Prince of Johor (Malaysia) since 2014. Right from the first days of being together, the Crown Princess has been loved and supported by many people. because of the knowledge base and beautiful appearance, noble temperament and open and close personality. The Crown Princess of Malaysia gave birth to her fourth princess a month ago. After getting married, the Crown Princess also gave birth to beautiful and lovely “children”. One month ago, she gave birth to her fourth child, a princess. Thus, the Crown Prince of Johor and his wife had two princes and two princesses. After giving birth, Khaleeda also quickly “re-exported” on social networks, showing warm and happy family photos. The figure of the Crown Princess after 4 births is also of great interest to many people. Accordingly, with full body photos, it can be seen that Khaleeda’s body is still quite chubby after giving birth, especially the second round is less slim. However, in return, her face was almost unchanged, broken, still maintaining a beautiful and youthful appearance. Her figure and beauty after 1 month of giving birth. Under the comment section, a large number of people have left praise for the beauty of the Crown Princess with 4 children: “She’s still so beautiful”, “She’s only been born for a month, but her aura is very good”, “She is neat and noble after giving birth”,… In terms of physique, Khaleeda will soon regain her neat and toned body because she has experienced 3 successful postpartum weight loss times. Recently on Instagram, the mother of 4 also updated the image of starting to return to the exercise regime after a month of rest. Her chosen subject is boxing. The baby has just turned a month, the Crown Princess has begun to practice to get in shape. Earlier during her pregnancy, Khaleeda also focused on diet and exercise to control weight. She mainly eats a variety of vegetables and fruits and drinks enough water. In terms of training, in the first 3 months, she continued to exercise in the gym with light weights, in the second 3 months, she gave up weight training and only practiced with bare hands. Until the last 3 months of pregnancy, to ensure the safety of the baby, she will only do gentle Pilates exercises. Her figure when pregnant for the 4th time. Young face, contours even without much makeup. In addition, taking care of the children by herself is also a method to help this pregnant mother stay active and full of energy, the body is not heavy and sluggish. Many nursing mothers said that they hope that after losing weight and getting in shape successfully, the non-Malaysian crown prince will continue to share the necessary secrets with everyone. A simple and effective way to lose weight for mothers after giving birth Cut calories: The best way to lose weight is to cut calories in your daily diet. – Eat a lot of “superfoods” ie foods rich in protein such as lean meat, chicken, beans, fish and calcium supplements from milk, yogurt, … Eat healthy snacks: Eat snacks that are low in fat and sugar, like fresh fruit or cereal. – Breastfeed or pump regularly. Drink plenty of water: When you’re dehydrated, your body won’t burn as many calories. Drink at least 1 glass of water each time you feed. – Get enough sleep: You should try to sleep at least 7 hours a day (not necessarily in a single time). When a mother does not get enough sleep, the risk of weight gain will increase higher than normal. – Do gentle, appropriate exercises. – Eat many meals, each meal is moderate.

This is considered a very convincing result because right from the beginning of the season, this beauty has always been present in all beauty rankings and is considered a “serious” opponent than ever. The representative of Mexico was excellently crowned Miss Universe 2020. Andrea Meza has a beautiful face, height of 1m82 and a toned body. Currently, she works as a model, makeup artist and runs a computer software company. Following Miss Universe 2020’s personal page, it can be seen that in order to have a toned physique, with a standard 3-round measurement, Andrea has regularly practiced sports such as running, climbing, boxing, exercises. doing cardio to burn fat… She often changes exercises to keep herself from getting bored. To have the perfect sexy body as it is now, Miss Universe 2020 Andrea Meza has worked very hard to exercise. The new Miss Universe loves climbing mountains. As well as not afraid to experience adventure games. Boxing is also applied by Andrea Meza to lose weight. Besides practicing many sports, the new Miss Universe also follows a strict diet. On her personal page, the Mexican beauty often shares photos of herself in the kitchen preparing nutritious, healthy and high-protein dishes. Sometimes she also fasts to purify her body. In addition, drinks such as smoothies from a variety of fruits, watermelon, cucumber, kiwi, tomato, mango… are also added to her diet by Andrea. Miss Universe 2020 implements a diet to own a sexy, toned body. The owner loves to eat a lot of green vegetables, fruits and minimize starch.

On the morning of May 14 (Vietnam time), 74 Miss Universe contestants entered the national costume contest. The representative of Albania – Paula Mehmetukaj – competed in the first contest with the outfit “Queen of the Earth and the sky”. The design has a long red skirt that symbolizes blood vessels, combined with small crystal stones – the so-called underground treasures. Mehmetukaj says she’s like an eagle spreading her wings in this outfit. The Australian beauty wears a black swan costume, which at first glance is simple but weighs nearly 9 kg and has 105 feathers made from bucket fabric. As she walked, the feathers began to rotate thanks to the small motor inside. It took over 100 hours for designer Nicola Yeung to complete this outfit. Miss Universe Barbados rocked the stage with her energetic, powerful steps. According to Missosology, the bodysuit is studded with hundreds of mirror pieces, plus the gorgeous feather skirt is a blend of sun, sea and sand images. Miss Universe contestants have meticulously prepared, monumental about national costumes. Contrary to 2019, the stage this season has an investment, is more spacious, and allows the girls to express themselves. Representatives of Colombia (left) and Costa Rica are two heavyweights of the Americas region. The national costume contest took place only a few hours after the closed interview round, but the girls still kept their confidence and showed their best in front of the judges. Appearing in a traditional sari, the Indian representative was warmly cheered. Since the start of the contest, this beauty has always been on the list of the best candidates for the crown. The same idea is birds, but the costumes of the contestants all bring the beauty and characteristics of their own country. Francisca Luhong James – representative of Malaysia – brought the model of the Kampung house on stage. The national costume weighs 45 kg, so James had to ask 2 more backstage staff to assist. Her performance took up about 3 minutes. Miss Universe Myanmar caused emotions with a simple appearance with the message “Pray for Myanmar”. She joined Miss Universe with only 3 suitcases but lost it. The beauty had no clothes to wear and had to ask for help from other contestants. Miss Universe Venezuela wore beautiful and sophisticated costumes, but disappointed because of the boring performance. As the last performer, Miss Khanh Van opened the cocoon, appeared charismatic with flexible catwalk steps and the highlight was a rhythmic swing. Before G, she had a problem with the supporting frame and cocoon, fortunately Khanh Van fixed it in time to step out on stage.

Prince Philip and Queen Elizabeth II have been happily married for 74 years. (Source: Getty Images) In a recent status on Twitter, the British Royal Family said, Prince Philip has always loved design work. In addition to overseeing and designing the Royal Yacht Britannia, he also designed an engagement ring and bracelet for Princess Elizabeth II (now Queen of England). Often the jewelry of the Royal family always has a story to celebrate. The ring Prince Philip used to propose to Queen Elizabeth II in 1947 was made from the tiara of his mother, Princess Alice of Battenberg, niece of Queen Victoria. Princess Alice, mother of Prince Philip. (Source: Getty Images) According to the Town and Coutry , in 1946, upon learning of her son’s intention to propose, Princess Alice gave Philip the tiara she had been given on her wedding day for him to use as a suitable ring for his fiancée. Prince Philip at that time collaborated with the famous London jeweler Philip Antrobus Ltd. to design your own 3-carat diamond ring surrounded by 10 smaller diamonds. The engagement ring has always been worn by Queen Elizabeth II. (Source: Getty Images) The diamonds themselves date back to the late Romanov dynasty. On her wedding day, Philip’s mother was presented with the tiara used on the wedding day of Tsar Nicholas II and Tsar Alexandra of Russia, the last rulers of the Russian Empire, who were also important persons. distantly related to her. Queen Elizabeth II wears an engagement ring and bracelet designed by Prince Philip. (Source: Getty Images) Not only that, Philip also chose the remaining diamonds in the crown to make a diamond bracelet to give as a wedding gift to Elizabeth II. The necklace was later gifted by the Queen to her granddaughter-in-law Kate Middleton. The Duchess of Cambridge wore the bracelet on her left hand during a reception for Chinese President Xi Jinping in October 2015. (Source: Getty Images) (according to Insider)

In addition, she also expressed her love for Prince Philip with jewels attached to her clothes or on her fingers. Prince Philip and Queen Elizabeth II. Engagement ring made from mother-in-law’s crown The British Queen’s engagement ring becomes special and historic when it is made from the crown of Princess Alice – Prince Phillip’s mother. This tiara was given by Tsar Nicholas II and Alexandra with the same jewelry set as a wedding gift to the heir to the British royal throne. Before proposing to Queen Elizabeth II, the deceased prince removed the diamonds on the crown to design a special engagement ring, with a 3-carat diamond placed in the middle and 10 smaller diamonds on both sides. He gave his wife the betrayal at Buckingham Palace, England. Engagement ring of the Queen of England. The bracelet marks the 5th anniversary of the wedding According to the Express The gold bracelet is studded with diamonds and rubies with the initials of Queen Elizabeth II and Prince Philip’s names engraved on the inside. This is a gift from the late prince to his wife on the 5th wedding anniversary. The jewelry is worn by the queen whenever she appears with the other half during major British royal events. Prince Philip presented a golden bracelet to the queen in 1952. Symbol for the relationship between the queen and the prince In 1946, Queen Elizabeth II was given a brooch before marrying Prince Philip. After that, the item became a symbol of their relationship. According to the The Telegraph A shipbuilder presented the queen with a chrysanthemum brooch made of platinum, diamonds and jade after she launched an oil tanker. Sometime after that, the accessory was named Honeymoon Brooch because the queen wore it on her honeymoon. After this, she continued to use it at the wedding anniversary party and during the time Prince Philip was hospitalized. The British Queen’s chrysanthemum brooch. The brooch is made from rubies The Scarab Brooch brooch made of gold, diamonds and rubies was given to the Queen of England by Prince Philip in 1966. This is a jewelry created by designer Andrew Grima. The Queen wears this accessory on many costumes while attending various events such as the 2008 trip to Slovenia. Queen Elizabeth II often used brooch made of gold and rubies. Heart-shaped accessories The Cullinan V brooch is made from an 8.8-carat diamond with smaller platinum stones. The public believes that the Queen of England wears heart-shaped accessories to commemorate her 70-year marriage. However, Vanity Fair argued that the queen’s item was related to British imperialism. She wears a heart-shaped brooch in response to protests calling for the demolition of the statue of Cecil Rhodes – former British Prime Minister of the Cape colony and founder of the diamond company De Beers – that took place in England at the time that point. Heart-shaped brooch on the British queens couple’s 70th anniversary.

When she first entered the Vietnamese showbiz, Miss Do Thi Ha was still quite awkward with sexy evening gowns. Posing in front of the lens of Miss Vietnam 2020 Not really diverse, possessing a radiant smile, but Do Thi Ha has yet to show off the most beautiful face. However, it is undeniable that she pays much attention to her personal image every time she appears in public. Do Thi Ha is well-groomed and chooses an emotional makeup style. Miss often wears prominent red outfits when attending events. She has also grown accustomed to high-cut, chest-cut dresses to create a more natural pose. When she appeared next to runner Nguyen Lam Diem Trang, Do Thi Ha showed off her youthful beauty, but she still needed to learn from her seniors about the charisma in front of the camera. Do Thi Ha’s charming beauty matches traditional ao dai outfits. After 3 months crowned Miss Vietnam, Do Thi Ha became more and more professional in fashion style to attend the event. Miss born in 2001 knows how to pose to show off her sexy body curves. Not only posting photos of the event with the well-groomed fashion, Miss Vietnam 2020 confidently showed off the street style and catwalk images with streetwear costumes on her personal page. In addition to the evening gown with vibrant red or white tones and creamy foundation, Do Thi Ha also offers herself in more fussy colors like cobalt blue, pastel blue with a bold embrace design. After half a year of coronation, Miss Do Thi Ha constantly strives to perfect her image in many different activities. She confidently wore sexy cut-out designs, posed more professionally and showed off her seductive facial features.

Not long ago, on her personal page, Miss Tieu Vy posted a series of extremely attractive white corset photos. Post by the queen has caused “internet storm” and received many interactions. Miss Tieu Vy pursues a sexy, hot image. Thousands of winged comments complimented Tieu Vy’s sensuality and physical beauty. Pursuing a sexy and daring fashion style, the girl born in 2000 surprised the public by revealing her strong personality and gradually changing her fashion sense. Miss Tieu Vy becomes increasingly sexy and hot after 2 years of coronation After the end of her term, Tieu Vy cut her long hair that was attached during her term of office. Possessing an outstanding beautiful face, the image of a queen with short hair also makes fans excited. Improving a variety of circumstances, Tieu Vy expresses her newness in each layout when appearing, from clear, gentle to sexy, luxurious. Pursuing a sexy fashion style, Tieu Vy does not hesitate to show off her hot curves. After 2 years of incumbent with a beautiful and standard image, Tieu Vy aims to be a versatile, colorful woman in her career. For Tieu Vy, being sexy needs the right place in the right place and suitable for the environment and events, not just wearing it according to your own preferences. After giving the crown to the new Miss, Tieu Vy still retains the image of a young person who wants to use her voice to spread positivity to the community and especially women. In her latest post, the beauty also showed her support for the “Feminist” movement with the statement: “As a woman, to love herself. Maybe you are not perfect but must know how to perfectly care and love ”. Her status line has quickly received a lot of responses from fans, helping women to become more confident and love themselves. Tieu Vy cried when talking about her 2 years incumbent:

Selected data on April 23 Tesla announced the accident vehicle data again late at night Tesla re-issued a document on the 22nd night, saying that it fully accepts the decisions of the State Administration of Market Supervision and the Zhengzhou City Market Supervision Administration, and does its best to actively cooperate with all relevant investigations, and earnestly fulfill its main responsibility for quality and safety, and provide consumers with High-quality and safe products and services. Tesla said that as of April 21 so far, it has provided complete driving data half an hour before the accident, and has proactively contacted relevant parties to communicate and report the relevant situation on many occasions. (China News Service) The torch relay of the Tokyo Olympics is now the first person infected with the new crown, a male police officer NHK reported on April 22 that the Tokyo Olympic Organizing Committee announced that a male police officer who had participated in the traffic control work of the Olympic torch in Xiangshan County on April 17 tested positive for the new crown. This is the first time a new crown-infected person has appeared among the staff of the Tokyo Olympic torch relay. The infected person is a male police officer in his 30s from the Transportation Department of the Takamatsu Kita Police Station. According to reports, during the course of his duty, the police officer did not have any contact with people along the torch relay. (Overseas Network) In the first quarter, Shanghai’s per capita income exceeded 20,000 yuan, and the per capita income of eight provinces exceeded the national level From the data point of view, in the first quarter of this year, the top ten provinces with per capita disposable income of residents were Shanghai, Beijing, Zhejiang, Jiangsu, Tianjin, Guangdong, Fujian, Shandong, Chongqing and Liaoning. Among them, the per capita disposable income of residents in the first eight provinces exceeds the national average, and these eight provinces all come from the eastern coastal areas. The per capita disposable income of Shanghai residents reached 21,548 yuan in the first quarter, making it the only province with more than 20,000 yuan. As Shanghai has a large number of multinational companies and financial institutions such as the Shanghai Stock Exchange, the headquarters economy, R&D and innovation are very prominent, which attracts a large number of talents, and these groups have higher incomes. (China Business News) The British government cuts 95% of aid to China, leaving 900,000 pounds Recently, British Foreign Minister Raab announced that in this fiscal year’s official development assistance funds, aid to China will be cut by 95%, leaving less than 1 million pounds. The Conservative Government has boldly stated that it will allocate 0.7% of the country’s income every year for international aid. According to the British “Mirror” report, due to the impact of the new crown natural disaster, the anti-epidemic “man-made disaster” and the economic shock of Brexit last year, this expenditure will be reduced to 0.5% this fiscal year. The US “Politician” News Network added that one-third of the UK’s official development assistance funds are still invested in the “Indo-Pacific” and South Asia. The aid funds to China will be cut by 95%, leaving 900,000 pounds (approximately 8.13 million yuan) to fund open society and human rights projects. Some netizens on Weibo ridiculed that the British aid is not as good as the one-year revenue of some Internet celebrity shops in Changsha. In July last year, the British Department of International Development announced that the British government directly and indirectly provided assistance to China of 71.6 million pounds in 2018. (Observer Network) South Korea imported kimchi in the first quarter from China Yonhap News Agency recently reported that the export value of kimchi in the first quarter of this year was 46.57 million U.S. dollars, breaking a single-season export record. Imports amounted to 38.5 million U.S. dollars, and the trade balance achieved a surplus of 8.068 million U.S. dollars, the highest since April 2009. According to reports, the export value of kimchi in the first quarter of this year increased by 54.3% year-on-year, and the import value increased by 7.4%. From the perspective of import and export volume, the export volume was 11,181 tons and the import volume was 67,940 tons. Exported kimchi was US$4,165 per ton, much higher than the US$567 of imported kimchi. All imported kimchi originates from China. From the perspective of the kimchi export market, exports to Japan were US$24.72 million, an increase of 67.9% year-on-year, exports to the US were US$8.46 million, an increase of 80.6%, and exports to Hong Kong were US$2.34 million, an increase of 50.3%. (Forbes Chinese website)

Source | People’s Daily Health Client

Author | Health Times reporter Li Xin

Editor | Hu Xin

On April 22, local time in Ottawa, Canada, the Canadian government announced that all commercial and private passenger flights from India and Pakistan will be prohibited from entering the country. The ban will take effect from 23:30 on April 22, Eastern Time, for a period of 30 days. And after the ban takes effect, passengers who fly to Canada through these two countries must obtain a negative test for the new crown virus from a third country before continuing to Canada.

According to the news published on the official website of the Canadian government, entering Canada must be tested for the new coronavirus and be quarantined for 14 days. The Public Health Agency of Canada has been monitoring case data and found that the proportion of virus carriers on flights to India and Pakistan is increasing recently.

On April 21, Quebec, Canada, discovered the first case of infection with the mutant new coronavirus B1617 found in India. Canadian Minister of Intergovernmental Affairs Dominic LeBlanc (Dominic LeBlanc) said on the 22nd that the implementation of these travel restrictions is to prevent the spread of the new crown pneumonia virus and its variants in Canada.

According to data from the Canadian government’s official website, from February 22 to April 19 this year, the Public Health Agency of Canada received a total of 274,822 incoming passengers’ arrival test results, of which 1.4%, or 3732 passengers, were tested for the new crown pneumonia virus. Was positive.

Toyota Crown Kluger is not the only surprise that the Japanese automaker brings to this Shanghai Motor Show, because sharing the stage with it there is also another Crown model, but instead of an SUV, Here’s a minivan again. Similar to the Crown Kluger SUV, the Crown minivan is also a brand-new “closed” model, not a completely new one. It is named the new Toyota Crown Vellfire 2021 and sold through a local joint venture with Toyota’s FAW. If the MPV Toyota Crown Vellfire makes you feel completely strange, then maybe the Alphard produced by the GAC-Toyota joint venture will remind you of something because they are essentially the same model but with a foreign style. slightly different. According to the manufacturer’s announcement, Crown Vellfire will be sold exclusively in the Chinese market together with its brother Crown Kluger. Strangely, Toyota doesn’t seem to have made a clear press release about the Crown Vellfire, and its launch at the Shanghai Auto Show this year was noisy either. Through some local sources, we know that the car will have 3 versions, the price of the Toyota Crown Vellfire 2021 ranges from 839,000 to 920,000 yuan (about 2.97 to 3.26 billion). All three versions are equipped with a hybrid powertrain with a 2.5-liter engine that produces a maximum capacity of 163 hp combined with a CVT gearbox. This 3-row minivan is the most expensive Toyota-branded product in the Chinese market and it retains the Toyota logo on the steering wheel while the Crown Kluger has a distinctively distinctive logo. In terms of appearance, the new model will adopt a different design style from Alphard. The overall shape of the Crown Vellfire looks a bit sportier, the front grille has beautifully decorated chrome strips, and the headlights on the sides adopt a detached design. The front of the car has a “crown” logo that matches the Crown brand name and represents the true position of this model, and the lower two sides are two large wind cavities that look extremely pit to create a visual impression for people. look. The rear of the car is decorated with glass doors with a large surface area, and similar to the top, there are also large shiny chrome strips. The rear lights also use a transparent lampshade design, plus a hidden exhaust layout that makes the overall new car look more prominent. For the interior, the Toyota Crown Vellfire uses a mechanical instrument panel and a 4-spoke multifunction steering wheel. Meanwhile, the touchscreen center looks quite large and is placed flat on the dashboard instead of floating like many other new models in China. The center console still retains some of the traditional buttons and knobs, but does not lose the luxury look. In terms of technology, this high-end minivan is equipped with a variety of safe driving assistance functions, including a forward collision early warning system with pedestrian detection, support for marine identification. signaling, lane departure warning, automatic long-distance headlight switching, adaptive cruise control, and much more. Video: Details of the new Toyota Crown Vellfire 2021 MPV.

Nepal reopened the spring mountaineering season in early April after closing mountaineering activities for a year. However, just a few weeks later, at least one mountaineer has been diagnosed with new crown pneumonia.

The climber’s name is Erlend Ness, from Norway. He was diagnosed just last Friday and is currently in hospital isolation. He is not sure where he contracted the virus, but it is very likely that he contracted it in a tea shop in the Khumbu Valley under Mount Everest.

Erlend Ness feels unwell at base camp

While preparing for the climb at the base camp, he experienced intense discomfort and difficulty breathing. On April 15, a helicopter took him from the base camp and taken him to the hospital in Kathmandu. Fortunately, he purchased new crown insurance in advance, including the rescue cost.

“Not many climbers used masks.” He recalled to an Associated Press reporter. According to a report by the mountaineering website Explorersweb, all climbers currently in the base camp have undergone two new coronavirus tests before leaving Kathmandu.

A Sherpa in his team has also been diagnosed with the new crown.

Erlend Ness in the hospital

In response, a senior mountain guide Austrian Lukas Furtenbach warned that Nepal should immediately check all climbers, guides and Sherpas and take safety measures. The virus is likely to have spread to hundreds of others and is now on Mount Everest. Spread among climbers camped in the base camp.

“We now urgently need to conduct large-scale testing in the base camp. Everyone must be tested, each team must be quarantined, and no contact between teams is allowed.” Furtenbach said. “Start now, otherwise it will be too late.”

He complained that only members of his team were still following the epidemic prevention guidelines, washing hands as usual, keeping a safe distance, doing virus tests every few days, and wearing masks. But the other climbers in the base camp didn’t care, and often invited people from other teams to parties.

Nepal’s economy is heavily dependent on Mount Everest climbing activities. According to the Kathmandu Post, the Nepalese government earns 4 million U.S. dollars each year by issuing Mount Everest climbing permits. According to data from the Nepal Mountaineering Association, 80% of Nepalese income comes from mountaineering activities and the tourism industry surrounding it. In 2019, 54,000 were directly employed by climbers who came to Mount Everest, including cooks, drivers and Sherpas who assisted in climbing.

Mount Everest is the “food and clothing parent” of many Nepalese

The traditional spring mountaineering activities start in April, and about 40 mountaineering teams come to Mount Everest at this time each year. And last year, due to the new crown epidemic, Mount Everest was closed, which was also a heavy blow to Nepal.

This year, after Nepal announced the resumption of spring mountaineering, hundreds of climbers are expected to try to reach the summit. The Nepal Immigration Department stated that all travelers entering Nepal must present a negative test report for the new coronavirus within 72 hours, or a certificate of completion of the new crown vaccination. Tourists from countries with variant strains need to be quarantined at the hotel for an additional 10 days.

(This article is from The Paper. For more original information, please download the “The Paper” APP)

After being presented as a documentary in China, the Toyota Crown Kluger 2021 officially debuted at the 2021 Shanghai Motor Show. This model has many similarities with the Toyota Highlander 2021. Toyota Crown Kluger is equipped with 2.5L hybrid powertrain and E-Four all-wheel drive system. Other specific information has yet to be revealed, but Toyota said the model is built on the same TNGA-K platform as the Highlander in the US market and is comparable in size. Specifically, the Toyota Crown Kluger also has 3 rows of seats, length x width x height, respectively 5,015 x 1,930 x 1,750 mm, wheelbase 2,850 mm. Vehicles equipped with 18-inch alloy wheels as standard and optional 20-inch wheels. The Toyota Highlander 2021 was also launched in China at the same time as the Crown Kluger, using the same hybrid powertrain and the E-Four drive system. This engine has a capacity of 189 horsepower, significantly lower than the capacity of 240 horsepower on the Highlander for the US market. In terms of appearance, the Toyota Grown Kluger has a different car head than the Highlander. The headlights are the same, but the Highlander has a trapezoidal grille and a Toyota logo on the chrome bar near the top edge of the grille, while the Grown Kluger has a crown emblem, similar to Toyota’s full-size sedans. The wheels of these two models also have a different design. It is likely that the Toyota Crown Kluger and Highlander 2021 in China will be equipped with Toyota Safety Sense 2.0 package with radar-active cruise control, lane departure warning, automatic headlights, lane keeping assist. road and traffic sign recognition. Toyota says both the Crown Kluger and the 4th-generation Highlander will go on sale in China by mid-year. Selling price has not been announced by the company.

The Toyota Crown Kluger will only be sold in the Chinese market At the 2021 Shanghai Motor Show, Toyota has officially launched the legendary Toyota Crown high-rise version, called the Crown Kluger. Although officially launched, the model parameters are still kept confidential and only confirmed to use the hybrid powertrain. According to previously leaked information, the Toyota Crown Kluger is a bit longer and taller than the Highlander but the width and wheelbase are the same. The Toyota Crown Kluger engine, still according to the website above, is a 198 hp 2.5-liter hybrid gasoline – slightly lower than the version available in North America and Europe (243 hp). Vehicle weight falls to approximately 2,000 kg. Toyota Crown Kluger will use a hybrid engine For China, this is a completely new model, but for the global market, this can be considered only a luxury version of the 7-seat Toyota Highlander SUV, which has been renamed. Because Toyota Crown Kluger is developed and looks almost similar to the 4th generation Highlander. Meanwhile in China, Toyota Highlander is still only sold 3rd generation. At the exhibition, the car is also considered by the manufacturer (a joint venture between Toyota and FAW in China) as a special luxury version sold in parallel with the old Highlander on the market. The interior space on the Toyota Crown Kluger is almost identical to the 4th generation Highlander In addition, if you want to own the Toyota Crown Kluger, customers outside of China will only be able to buy through private import channels. As confirmed by related parties at the show, the Crown Kluger SUV will only be sold in China. Toyota Crown Kluger will open for sale in China officially in mid-2021 with details announced at the same time.

The overseas new crown vaccine “thrombus gate” continued to ferment. Following AstraZeneca, Johnson & Johnson’s vaccine was also urgently stopped.

On April 13, the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA) issued a joint statement stating that in view of the fact that the U.S. has reported 6 cases of “rare and severe” thrombosis after being vaccinated by Johnson & Johnson, It is recommended to suspend vaccination of Johnson & Johnson’s new crown vaccine.

In this regard, vaccine expert Tao Lina (Vaccines and Science) told the reporter of China Times that even if it is finally confirmed that the vaccines of AstraZeneca and Johnson & Johnson have caused rare blood clots, it is necessary to weigh the pros and cons before making a decision.

As the vaccines of AstraZeneca and Johnson & Johnson are both adenovirus vector vaccines, CanSino shares continue to fall sharply. From April 14th to 15th at noon, Cansino A shares reported 349.16 yuan per share, a cumulative decline of about 8% during this period; Hong Kong stocks reported 270.8 Hong Kong dollars per share, a cumulative decline of about 14% during the period.

Johnson & Johnson Vaccines Was Urgently Stopped by the U.S.

According to the official website of the FDA, Johnson & Johnson’s vaccine was approved for emergency use on February 27 for use by people over 18 years of age. It was developed by Johnson & Johnson’s Janssen Pharmaceuticals. This vaccine is an adenovirus vector vaccine. It only requires one dose. The most common side effects are pain at the injection site, headache, fatigue, muscle aches and nausea. Most of these side effects occur within 1-2 days after vaccination, and are mild to moderate and last for 1-2 days.

The above 6 cases of adverse reactions occurred during the vaccination process of more than 6.8 million doses of Johnson & Johnson vaccine, all women aged 18-48, who developed cerebral venous sinus thrombosis and thrombocytopenia at the same time 6 to 13 days after vaccination. This side effect is “extremely rare” and the treatment is different from common blood clots.

On April 14, the CDC’s Immunization Practice Advisory Committee met to discuss these cases, and the FDA has also begun investigating these cases. At present, it has not been confirmed that there is a clear causal relationship between rare thrombotic events and Johnson & Johnson’s new crown vaccine. The two agencies recommended that states suspend continued vaccination against Johnson & Johnson until the complete investigation process is over.

In response, Johnson & Johnson issued a statement on the 13th, saying: “We have been reviewing these cases with European drug regulatory agencies. We have decided to proactively postpone the promotion of the vaccine in Europe, and suspend all clinical trials of the new crown vaccine, and update the research. The guidance of the participants and the participants.”

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said that the suspension of the Johnson & Johnson vaccine is out of cautious consideration, allowing relevant institutions to further understand the status of patients with adverse reactions and the mechanism of side effects. The probability of such side effects is extremely low, so those who have been vaccinated by Johnson & Johnson need not be anxious.

The health department recommends that people who experience severe headache, abdominal pain, leg pain, or shortness of breath within three weeks after receiving the Johnson & Johnson new crown vaccine should contact their healthcare provider.

At present, the suspension of Johnson & Johnson vaccination will not have a major impact on the progress of the new crown vaccination in the United States. Jeff Zienz, an expert on the US White House’s New Crown Epidemic Response Team, said that Johnson & Johnson vaccines account for less than 5% of the current US vaccination records. The US government is working with states and partners to help the Johnson & Johnson vaccines that have been booked. The patient should be rescheduled to receive Pfizer or Modena vaccine as soon as possible.

In fact, four days before the United States stopped Johnson & Johnson’s vaccination, the European Union has begun to review the safety of the vaccine. The vaccine was approved for conditional marketing in the EU in March, but has not yet been delivered. According to the plan, Johnson & Johnson will provide at least 200 million doses of the new crown vaccine to the EU within this year.

Following AstraZeneca’s footsteps?

It seems that Johnson & Johnson has followed in the footsteps of another multinational giant, AstraZeneca.

In March, due to the symptoms of bleeding, thrombosis and reduced platelet counts among medical staff in Denmark, Norway and other places after vaccination, nearly 20 countries including Germany, France, Denmark, Norway, Iceland, Italy, Thailand, Austria, etc. once called for a stop. Sleek vaccination.

On April 7, expert teams from the European Medicines Agency (EMA) and the World Health Organization (WTO) successively issued statements stating that the vaccine developed by AstraZeneca and the University of Oxford may be related to rare blood clots. The EMA Safety Committee (PRAC) believes that rare thrombosis with thrombocytopenia should be classified as a very rare side effect of the AstraZeneca vaccine. However, the overall benefits of the vaccine in preventing new coronary pneumonia outweigh the risk of side effects.

PRAC conducted an in-depth review of the 62 cases of cerebral venous sinus thrombosis and 24 cases of splenic vein thrombosis reported in the EU drug safety database as of March 22, 2021. Among them, 18 cases were fatal. These cases were mainly from the spontaneous reporting system of the EU and the United Kingdom. Approximately 25 million people have received the vaccine.

PRAC pointed out that thrombosis occurs in cerebral veins (cerebral venous sinus thrombosis) and abdominal veins (splenic vein thrombosis) and arteries, accompanied by low platelet levels and sometimes bleeding. So far, most of the reported cases have occurred in women under 60 years of age within 2 weeks of vaccination.

AstraZeneca said that it will update the vaccine product instructions and add information about the vaccine and “very rare” thrombosis on the new label. Together with the WTO and EMA, we are conducting unified observations on patients with symptoms after vaccination and conducting further research.

At present, many countries have announced adjustments to the AstraZeneca vaccination groups, including the United Kingdom, the Philippines, Australia, South Korea, Belgium, etc., but there are differences in age. The United Kingdom advises against vaccinating AstraZeneca for people under 30 years of age, Belgium suspends vaccinations for people 55 years of age and under, Australia suspends vaccinations for people under 50 years of age, and Spain, South Korea and the Philippines only for people over 60 years of age Get the vaccine.

Recently, the “New England Journal of Medicine” published two important studies at the same time, analyzing the symptoms of thrombosis and thrombocytopenia in patients after vaccination with AstraZeneca.

In the first study, the Norwegian research team reported that 5 cases of rare venous thrombosis and thrombocytopenia were found in more than 130,000 vaccinators. High levels of antibodies against PF4-polyanion complex were detected in the blood of all patients. This antibody can activate platelets, leading to abnormal formation of thrombus and a decrease in the number of free platelets.

In the second study, the German research team analyzed the clinical and blood test data of 11 patients who experienced thrombosis or thrombocytopenia after being vaccinated with AstraZeneca in Germany and Austria. Testing of patients’ blood samples also found high levels of antibody responses to PF4-heparin complex or PF4. Historical studies have shown that other factors besides heparin may also trigger symptoms very similar to heparin-induced thrombocytopenia.

China’s Cansino vaccine implicated

It is worth noting that the vaccines of Johnson & Johnson and AstraZeneca both follow the path of adenovirus vector technology. Now that one after another is involved in the “thrombus gate”, are other adenovirus vector vaccines still safe?

At present, in addition to Johnson & Johnson and AstraZeneca, the satellite 5 (Sputnik-V) developed by Russia, and the new crown vaccine developed by China’s Cansino Biotechnology Co., Ltd. also belong to the adenovirus vector technology path. However, according to public information, the adenovirus vectors used in these four vaccines are different. The AstraZeneca vaccine uses the chimpanzee adenovirus vector, the Johnson & Johnson vaccine is based on the Ad26 adenovirus vector, and the Cansino vaccine uses the Ad5 adenovirus as the carrier. The first dose of the Russian satellite 5 vaccine uses Ad26 as the carrier, and the second dose uses Ad5 as the carrier. Carrier.

Affected by this news, Cansino’s stock price plummeted, A shares fell by 13%, and H shares fell by 18%. CanSino Bio had to issue an emergency statement stating that the Ad5 vector used by the company’s new crown vaccine is a common adenovirus that infects humans, which is different from the adenovirus vector used by AstraZeneca and Johnson & Johnson vaccines. As of the 14th, about one million people vaccinated with Cansino vaccine have not received reports of serious adverse events related to thrombosis. After the company’s statement was issued, the decline in Cansino’s share price narrowed. As of the close, Cansino A shares closed at 356.20 yuan per share, the decline narrowed to 6%; the decline of Hong Kong stocks also narrowed to 8%.

CITIC Securities believes that this phenomenon has not been found among the millions of vaccinators of Cansino vaccine; this has not been found in the previous use of Ad5 in other vaccines and drugs; after all, Ad5 is a viral vector with a high infection rate in humans. It is different from AstraZeneca, Johnson & Johnson and Carrier, and the probability of thrombosis is very different.

So, is Ad5 adenovirus vector safer? Taolina said that there are some studies on the thrombocytopenia caused by adenoviral vectors, but these studies are based on the results of high-dose systemic therapeutic applications.

In September 2011, Yu Xiunan and other researchers from the First Affiliated Hospital of Harbin Medical University published an article “Research Progress in Adenovirus Type 5 and Thrombocytopenia” in the Journal of Modern Laboratory Medicine, which mentioned that thrombocytopenia Symptoms are a major side effect of high-dose systemic application of adenovirus as a vector for gene therapy of carriers. Adenovirus can bind to CAR receptors on platelets, and can also bind to integrin receptors on platelets. “Recent studies have found that adenovirus may cause activated platelets. Adenovirus-induced thrombocytopenia is considered to be dose-dependent, saturated and reversible, which is consistent with the ligand-receptor mechanism. There are multiple views on the mechanism.”

Regarding the Johnson & Johnson vaccine, “I’m still suspending the use and continuing to evaluate it, but compared to no vaccination, I am expressly willing to accept the adenovirus vector vaccine.” Taolina said.

Christopher Lee in Charles & Diana: A Royal Love Story (1982): The late actor Christopher Lee gives up his familiar villain roles to play Prince Philip in Charles & Diana: A Royal Love Story. The film has a main content about the love story and wedding between Prince Charles and Princess Diana. Donald Douglas in Diana: Her True Story (1993): Veteran actor Donald Douglas plays Prince Philip in Diana: Her True Story – production based on Andrew Morton’s account of Charles and Diana divorce . In the movie, apart from Douglas, two other famous actors, David Threlfall and Serena Scott Thomas, play Prince Charles and Princess Diana. David Threlfall in The Queen’s Sister (2005): David Threlfall – an actor famous for his role as the patriarch of Shameless – portrayed Prince Philip with integrity in the BBC film about Princess Margaret’s life. James Cromwell in The Queen (2006): James Cromwell plays Prince Philip, paired with star Helen Mirren – who then won an Oscar for acting with the film. The two portrayed as Queen Elizabeth II and Prince Philip in the film recounting the royal reaction to the death of Princess Diana in 1997. Matt Smith in The Crown (2016-2017): The star of the Doctor Who series – Matt Smith – received a prestigious Emmy nomination for his appearance in The Crown. He plays Prince Philip in the first season of the popular movie on the Netflix platform. Tobias Menzies – The Crown (2019-2020): Tobias Menzies was the replacement for Matt Smith to take on the role of Prince Philip in seasons 3 and 4 of The Crown. Like his predecessor, he received an award nomination for his role, but at the Golden Globe 2020. Tom Courtenay in The Queen’s Corgi (2019): The veteran actor who received an Oscar nomination twice – Tom Courtenay – voiced Prince Philip in The Queen’s Corgi. In the humorous cartoon, the character is quite confused by the love and affection that the queen has for her corgi dogs.

Tonglu is located in Hangzhou, which has been called the “paradise on earth” since ancient times, on the middle reaches of the Qiantang River. This city is famous for its “green mountains, beautiful waters, long history and secluded environment”. If you come to Tonglu, Hangzhou, you must visit the Yaolin Wonderland. The unique karst landform is very spectacular. It is one of the most famous karst caves in the country. It is the “Crown of Caves in the Country” and is a typical representative of karst caves in East China. The painter Ye Qianyu once praised it: rare in China, rare in the world. The Yaolin Wonderland, 80 kilometers away from Hangzhou, is also one of the top 40 tourist attractions in China and one of the top ten tourist attractions in Zhejiang Province. In 2002, it was listed as a national 4A scenic tourist attraction. There are more than 20 limestone caves distributed in Tonglu County. The most famous is the Yaolin Cave. According to historical records, as early as the Song Dynasty, the poet Ke Yuezhai compared this cave to a fairyland. In the 12th year of Guangxu in the Qing Dynasty, Yang Baoyi, the prefect of Tonglu County This cave was nominated as “Yaolin Wonderland”, which is said to be a playground for gods.

The Yaolin Wonderland was formed in a limestone cave 100,000 years ago. The entire cave is one kilometer in depth. According to the structure of the cave, it is divided into seven cave halls with a total area of ​​28,000 square meters. The Yaolin Wonderland was first discovered in the Sui and Tang Dynasties, and was isolated from the world by the collapse of the cave entrance at the end of the Qing Dynasty. It was rediscovered in 1979 and attracted the attention of travel enthusiasts from all over the world with its magical topography and magnificent stalactite scenes. It can be imagined that in ancient times, the caves under the lighting of torches and bonfires, which were underdeveloped with lights, could be compared to the beauty of a fairyland. Nowadays, under the colorful lighting, it is like a natural artwork. Although it is one step away from the world outside the cave, there is a difference between “the world and the fairyland”. The setting of lighting and storyline is an ingenious combination of modern technology and ancient caves. The strange rocks of different shapes, strange ponds, strange caves, and the gurgling sound of underground water from time to time, plus the lights in the cave, really look like a fairyland.

There are 3 cave halls in Yaolin’s Wonderland, and the stalactites in each cave hall look different. There are attractions in the cave such as Yingbin Gate, Yinhe Waterfall, Jinjiguan Waterfall, Juxian Hall, Qionglou Yuyu, Ganoderma Lucidum Mountain, and Zizhu Forest. The first cave hall is welcoming tourists from all walks of life by more than 50 vividly sized lions and proboscis elephants, so it is also called “the lion elephant welcoming guests.” The most worth visiting is the “Jade Pillar Optimus” with a height of about 14 meters and a diameter of about 4 meters, which stands on the raised cliff in the second cave hall, and the beautiful “Thirty Three Heavens” in the third cave hall. And “Yaolin Yufeng”. If you don’t have a bit of imagination, you will probably think that this is a pile of stones of different shapes, but when you look up on the scene, you will be deeply impressed by nature’s supernatural work.

It is said that Yaolin’s Wonderland is a strange and incomparable cave world, and its magic is that it provides a vast world for mankind’s infinite fantasy world. The stalactites formed over hundreds of millions of years are colorful and dazzling. “Yao Chi is originally in the human world, it can be laughed at by ordinary people.” The natural world gives birth to infinite reveries. Man and nature are an inseparable whole. At the same time, they are constantly thinking about the relationship between themselves and nature. This is the combination of nature and humanities. Charm.

The overview of the TDTU 2021 Student Beauty Contest Semifinals, the atmosphere became extremely exciting and excited by the enthusiastic cheers from many students.

With topics “The beauty of diffusion”, TDTU 2021 Student Beauty Contest is coming to the end. The semi-final round was held with three competitions: the Co-Performance, the Elective Costume and the Traditional Costume Contest, with the aim not only to spread the standard beauty and wisdom but also to honor the beauty. modern and dynamic students TDTU.

The judges attending the semifinal include: Nam Vuong Truong Ngoc Tinh, top 5 Miss Vietnam 2020 Pham Thi Phuong Quynh, MC Phan Ngoc Phuong Uyen, Mr. Nguyen Nha, Mr. Minh Trung Beauty, fashion director Ta Nguyen Phuc, designer Minh Tuan Nguyen.

Opening the program with the concurrent competition of the TOP 40 contestants in simple costumes: white T-shirt and dark pants, the good coordination created an atmosphere stirring performance at Thao. TDTU Defense School, bringing excitement to the audience.

In the second part of the contest – the optional outfit part, TOP 40 showed confidence when wearing the custom outfits according to their own personality to shine in the fullest way. Each individual is a different color, contributing to a unique and colorful Semi-Final night.

Each contestant brings their own unique outfits and personalities, making a distinctive mark on their own at the Costume Buffet competition.

And with the last part – the Traditional Costume competition, the contestants fully demonstrated pure charm in pink ao dai dresses and white trousers – shirts. That is the spread of pride. Students of Ton Duc Thang University have 5 characteristics of TDTU students: Discipline, politeness, professionalism, creativity and service.

Candidates confidently express themselves in the school’s traditional pink ao dai.

TOP 20 contestants entered the final round of TDTU 2021 Student Beauty Contest.

Candidates crowned for the highest position in the final night of TDTU Student Beauty will represent TDTU students in the upcoming activities taking place inside and outside the school. This year’s contestants are highly appreciated when there are many bright faces, it is difficult to predict the final results of the contest.

Who will touch the prestigious crown? The answer will be at the final night of TDTU 2021 Student Beauty, which will be held on April 23 at Hall A – Ton Duc Thang University (No. 19 Nguyen Huu Tho, Tan Phong Ward, District 7, Ho Chi Minh City)

Through 3 fascinating and no less dramatic rounds, the jury has excellently found 20 bright faces to enter the final round of the competition, including:

1. Le Thi Ngoc Hieu – SBD: 075

2. Pham Van Giau – SBD: 010

3. Tran Pham Hoai Nhi – SBD: 107

4. Vu Quoc Trung – SBD: 017

5. Nguyen Huynh Thu – SBD: 151

6. Van Chi Bao – SBD: 019

7. Mai Gia Han – SBD: 074

8. Tran Viet Ngu – SBD: 026

9. Luu Thanh Phuong – SBD: 094

10. Luu Bao Thang page – SBD: 040

11. Hoang Hien Trang – SBD: 156

12. Truong Van Nghi – SBD: 083

13. Truong Thi Thu Hue – SBD: 089

14. Le Viet Tai – SBD: 030

15. Nguyen Thi Thuy Huy – SBD: 042

16. Le Huynh Quang – SBD: 364

17. Nguyen Bao Suong – SBD: 062

18. Danh Vu Hao – SBD: 391

19. Truong Bao Long – SBD: 103

20. Hoang Hanh Nguyen – SBD: 136

Toyota Crown Kluger SUV version is expected to be released in China soon

The 7-seater Toyota Crown Kluger has been revealed to be available in the Chinese market. Although it has not been officially announced by Toyota, the first images of this model have appeared, suggesting that the car will most likely debut at the upcoming Shanghai Auto Show this month.

Earlier, information from Japan from late last year also said that the current Crown label will be attached to an SUV, expected to be released in 2022. The United States and China will be the first markets to sell. this model.

The report also adds that the Toyota Crown SUV version will be called the Crown Kluger, developed based on the Highlander model applying the TNGA-K platform. The platform is also used on the Harrier, which debuted in Malaysia last week.

At a glance at the published images, the Toyota Crown Kluger will have the same overall look as the Highlander, but the front grille will be less chrome plated. The Crown logo is located in the center of the heatsink. The design of the fog lights on the exterior of the two models will also be different.

The tail design of the Toyota Crown Kluger has many similarities with the Highlander

The rear end, it seems that the Toyota Crown Kluger will also use the same design as the Highlander. But the rear trunk and lower bumper will be redesigned to make a difference.

Documents from China also reveal that the Toyota Crown Kluger will have a length, width, a height of 5,015 x 1,930 x 1,750 mm and a wheelbase of 2,850 mm. It also uses 18-inch sport wheels or 20-inch alloys.

The powertrain is said to be a 2.5-liter hybrid technology engine that produces 189 horsepower, lower than a similar engine on the Highlander sold in the US market.

The leaked specifications are not exactly identical to those of the Highlander. The car is 5,015 mm long, 1,930 mm wide and 1,750 mm high. Compared with the Highlander sold in the US, the Crown Kluger is a bit longer and taller, the same width. The 2,850 mm wheelbase is also the common point of the two cars.

Toyota Crown Kluger

According to Autohome, the Toyota Crown Kluger will not be as powerful as the Highlander XSE. The Crown Kluger’s hybrid system uses a 2.5L petrol engine combined with an electric motor, for 189 horsepower, much lower than the 295 horsepower from the 3.5L V6 engine of the Highlander XSE. Even if compared to the Highlander XLE hybrid, the Crown Kluger is still 54 hp less.

There is no information about the interior design, however, it is likely that the car will be equipped with more advanced materials than the Highlander despite sharing the same design. This is supposed to match the name Crown which is a car symbol of luxury in Japan.

It is expected that the Crown Kluger model will be officially launched at the Shanghai Auto Show, which will take place from April 21 to 28.