Part of this 58-year-old male patient’s vision has been restored, allowing him to recognize, count, locate and touch various objects displayed on the table in front of him. (Photo: New York Times) According to research results published on May 24, scientists in Europe and the US have applied optical genetic engineering to treat a patient who lost vision due to an inherited disease of photoreceptors. 40 years ago. This involves injecting them directly into the patient’s eye, combined with stimulation for several months by wearing light-emitting glasses, which convert images into pulses of light printed onto the retina. A 58-year-old blind man was able to partially restore vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy. The patient, who lives in France, was diagnosed with retinitis pigmentosa (RP), a degenerative eye disease that affects the retina at the back of the eye and causes it to stop working, almost 40 years ago. year. However, several months after the treatment, he was able to recognize, count, locate and touch various objects with the treated eye while wearing a pair of light-stimulating glasses. The researchers say that although their findings, published in the journal Nature Medicine, are still in the early stages, their work could be seen as a stepping stone to targeted treatments. new target for people with RP (RP – a condition in which the cells in the retina that receive light are disrupted, which can lead to total blindness). It is the most common inherited eye condition, affecting around 1 in 4,000 people in the UK. The researchers used a technique, called photogenetics, to genetically alter cells in the retina so that they produce light-sensitive proteins called channelrhodopsin. The treatment, which is done by injecting an eye into one eye, activates the gene that codes for a channelrhodopsin protein called ChrimsonR, which senses amber light. The team also developed specialized goggles equipped with a camera to capture and project visual images onto the retina at amber wavelengths of light. The patient then trained for several months as the genetically engineered cells began to stabilize. Seven months later, the patient began to show signs of improvement in vision, the researchers said. The team also said their patients were “excited” after this first experience of partial vision. With the aid of the light-stimulating glasses, the patient was able to locate, recognize, touch and count objects such as notebooks, pin boxes and glasses on a white table in front of him. The researchers also read the patients’ brain activity using a technique known as an electroencephalogram. A tortoise is alternately raised or removed from the table, and the patient must press a button to indicate whether it is there or not. The results from the experiments show that patients can recognize with 78% accuracy. Although this type of optical genetic therapy may be beneficial in restoring visual function in people with RP-related blindness, more results from this trial are needed, the researchers say. clearer picture of the safety and effectiveness of this approach. José-Alain Sahel, lead author of the study from France’s Sorbonne University and the National Center for Scientific Research, said: “It is important that blind patients suffer from various types of neurodegenerative diseases. and functional optic nerve would likely qualify for treatment. However, the effectiveness of the treatment depends on the extent of the patient’s optic nerve degeneration. He said it will take more time to study this method before it can be put into practice. Quynh Hoa According to The Irish Times

Part of this 58-year-old male patient’s vision has been restored, allowing him to recognize, count, locate and touch various objects displayed on the table in front of him. (Photo: New York Times) According to research results published on May 24, scientists in Europe and the US have applied optical genetic engineering to treat a patient who lost vision due to an inherited disease of photoreceptors. 40 years ago. This involves injecting them directly into the patient’s eye, combined with stimulation for several months by wearing light-emitting glasses, which convert images into pulses of light printed onto the retina. A 58-year-old blind man was able to partially restore vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy. The patient, who lives in France, was diagnosed with retinitis pigmentosa (RP), a degenerative eye disease that affects the retina at the back of the eye and causes it to stop working, almost 40 years ago. year. However, several months after the treatment, he was able to recognize, count, locate and touch various objects with the treated eye while wearing a pair of light-stimulating glasses. The researchers say that although their findings, published in the journal Nature Medicine, are still in the early stages, their work could be seen as a stepping stone to targeted treatments. New target for people with RP (RP – a condition in which cells in the retina that receive light are disrupted, which can lead to total blindness). It is the most common inherited eye condition, affecting around 1 in 4,000 people in the UK. The researchers used a technique, called photogenetics, to genetically alter cells in the retina so that they produce light-sensitive proteins called channelrhodopsin. The treatment, which is done by injecting an eye into one eye, activates the gene that codes for a channelrhodopsin protein called ChrimsonR, which senses amber light. The team also developed specialized goggles equipped with a camera to capture and project visual images onto the retina at amber wavelengths of light. The patient then trained for several months as the genetically engineered cells began to stabilize. Seven months later, the patient began to show signs of improvement in vision, the researchers said. The team also said their patients were “excited” after this first experience of partial vision. With the aid of the light-stimulating glasses, the patient was able to locate, recognize, touch and count objects such as notebooks, pin boxes and glasses on a white table in front of him. The researchers also read the patients’ brain activity using a technique known as an electroencephalogram. A tortoise is alternately raised or removed from the table, and the patient must press a button to indicate whether it is there or not. The results from the experiments show that patients can recognize with 78% accuracy. Although this type of optical genetic therapy may be beneficial in restoring visual function in people with RP-related blindness, more results from this trial are needed, the researchers say. clearer picture of the safety and effectiveness of this approach. José-Alain Sahel, lead author of the study from France’s Sorbonne University and the National Center for Scientific Research, said: “It is important that blind patients suffer from various types of neurodegenerative diseases. and functional optic nerve would likely qualify for treatment. However, the effectiveness of the treatment depends on the extent of the patient’s optic nerve degeneration. He said it will take more time to study this method before it can be put into practice. Quynh Hoa According to The Irish Times

The French Mastiff is a breed of dog that originated in France. They have an impressive appearance with a large, heavy, wrinkled head. Although very loyal and brave, they are the dog with the shortest life expectancy in the world because the intestines are very sensitive, so it can easily lead to death. Average life expectancy: 5-7 years 2. Chinese Hound – Pastoral dog Chinese Hounds have appeared for a long time in China and Southeast Asia, they are often kept in rural areas for the purpose of looking after the house and protecting the property of the owner. They are also very loyal and courageous, often accompanied by their owners to hunt, and can even help look after livestock. In fact, if cared for carefully, the life expectancy of this breed is very long, but many people do not care to protect them, plus dog theft rages in the countryside, so their lifespan is usually only a few years. Average life span: About 7 years 3. Great Dane (Germany) Different from the current characteristic that the breed has an extremely gentle personality, very shy, even afraid of plastic bags, in the past, the Great Dane dog was used to pull carts, protect, track traces. patch. Although considered very healthy, they often suffer from inherited diseases of the bones, lungs, heart and eyes. Average life expectancy: 6-7 years 4. Irish Wolfhound True to its name, the Irish wolfhound originated from its breeding purpose of hunting wolves, developed from hunting dogs in war and in everyday life. They are the tallest dog in the world, very similar to the Greyhound and very brave. However, because they often suffer from bone and cardiovascular diseases, especially gastric torsion, which is common in this breed, their life expectancy is usually not high. Average life expectancy: 6-8 years 5. Borzoi Dog The Borzoi is a Russian breed of hunting dog that specializes in hunting wolves, bred from a long-haired sheepdog. They were once loved by the Russian nobility and were often seen as gifts among the nobility. In Vietnam they are called poodles. This is a quite special dog in terms of personality, they are proud and especially loyal to their owners, quite discreet, quiet but also love to run. Average life expectancy: 7-8 years 6. Bern Mountain Dog The Bern Mountain Dog is a breed of dog originating from Switzerland, descended from wolves that were raised on farms to guard and pull carts. Unlike other hunting dogs, Bern mountain dogs are active but not too naughty, very friendly with people and other domestic animals. Average life expectancy: 6-8 years 7. Newfoundland Dog The Newfoundland dog originated in Eastern Canada, used for many different purposes such as pulling carts, carrying goods, and rescue. Therefore, they are considered “the most desirable dog breed in the world” and are also nicknamed “rescue dogs”. Although the Newfounfland dog has a massive, large body that easily scares others, the Newfounfland dog is extremely friendly and gentle. They also love to swim and are extremely fond of children. Average life expectancy: 8-10 years 8. Rottweiler The Rooster belongs to the Italian mastiff breed, often trained to become a working dog because of its strong health, intelligence, endurance and good fighting ability, and also has its own independence in character. In Vietnam, the Rooster is a favorite military dog. Average life expectancy: 8-10 years 9. Labrador retriever The Labrador (commonly known as the Lab), is a popular hunting dog in the United States and is often used to bring back prey to the owner during hunting. Their name is derived from the Portuguese word “labor”. On the body of this breed, there are still many characteristics of hunting dogs, such as very strong teeth, very large nose, sensitive to odors. They are very sensitive to eating, if the diet is not reasonable, they will lose a lot of hair. Their average lifespan is 8 – 12 years. The above is only information about the average life expectancy that these dogs usually reach. In fact, the true lifespan of a dog depends on the training, nutrition and care that people give them. According to Sohu