Marie Antoinette syndrome is a phenomenon in which a person’s hair suddenly turns white (depigmentation). The condition’s name comes from the folk tale of French queen Marie Antoinette, whose hair is said to have suddenly turned white before her execution on October 16, 1793. People often assume that this syndrome is caused by pressure – perhaps this is most evident in the photos of the head of state before and after taking office. Compare President Obama before and after taking office, retiring. However, because the specific mechanism of graying hair has not been elucidated, it is not clear that 3 factors of aging, genetic factors and stress will affect gray hair to what extent. Recently, researchers from Harvard University published a study in the journal Nature that identified the mechanism by which rat hair turns gray prematurely under stress. The average human scalp has 100,000 hair follicles, and humans also have many different hair colors. Hair color is determined by melanocytes, which produce melanin that absorb light in various combinations. Melanocytes are derived from melanocytes (MeSC), located in the protruding part of the hair follicle. The hair growth cycle is divided into three phases, namely the anagen growth phase, the catagen resting phase, and the telogen long metabolic (shedding) phase. Hair growth cycle: growth phase, resting phase and shedding phase (from left to right). Melanocytes are produced during the growth phase. As a person ages, the melanin stem cells will gradually deplete, and the pigment produced will have a “salt-and-pepper” color, then turn gray, and finally white – the pigment is completely lost. in all hair follicles. At first, researchers suspected that stress would trigger an immune attack on melanin stem cells. But this was later proven to be a false hypothesis, as the mice lacked immune cells but remained mutated and had white spots. Stress increases the secretion of the hormone cortisol, so researchers are beginning to suspect that the hormone cortisol is responsible for the hair color change. However, when the cortisol-producing glands were removed in the mice, the mice’s fur would still turn white. Finally, the scientists focused on the sympathetic nervous system, the system in the body that is used to control the stress response in dangerous situations. Through studies, scientists discovered that melanocytes are located in the bulging part of the hair follicle, surrounded by neurons of the sympathetic nervous system, and release a neurotransmitter molecule. nerve is called norepinephrine. Melanin stem cell activity under normal and stressful conditions. As can be seen in figure a, under normal conditions, melanin stem cells (MeSCs) migrated from the bulge (in the direction of the red arrow) and differentiated into melanocytes during the analysis. From there, melanocytes synthesize pigment to make the regenerated hair dark. During the degenerative and resting phase, these stem cells begin to die. However, in the next growth phase, there will still be a large amount of new MeSC used to replace the dead stem cells. In figure b, the researchers found that external pressure stimulates and activates the sympathetic nervous system, increasing adrenaline release in the hair follicles. Norepinephrine then causes the MeSCs to completely transform into melanocytes, and none of the stem cells survive the growth phase in the next cycle. Since no new melanocytes are produced, the hair is naturally greyish white. The researchers also tested the effects of different pressures on the fading of the mice’s fur. At different stages of hair growth, they exposed the mice to three different stressors – pain, limited mobility, and psychological stress. All three of these factors induce MeSC depletion, which eventually leads to the appearance of white hairs. Previous popular theories believed that stress-induced hormonal changes (such as corticosterone) or autoimmune reactions were responsible for graying hair. The researchers examined these underlying mechanisms, first by blocking corticosterone signaling, and then by stressing the mice’s immune systems. In either case, corticosterone changes or autoimmune responses did not induce MeSC depletion. However, the researchers found that the expression of MeSCs depends on an adrenaline receptor, which responds to adrenaline. The adrenal glands are the main source of adrenaline. But surprisingly, the researchers found that removing these glands still did not prevent the mice’s coat color from turning gray under stress. Another source of adrenaline is the sympathetic nervous system (SNS), which is active in response to stress. The researchers demonstrated that the bulge area is internally connected by sympathetic neurons. Using neurotoxin molecules to destroy the SNS or prevent sympathetic neurons from releasing adrenaline could prevent hair from turning gray due to stress. Next, the researchers studied mice with activated sympathetic neurons and found that over-activating the SNS in these mice could cause hair to turn gray without stress. Taken together, these results indicate that adrenaline released from activated sympathetic neurons induces MeSC depletion. The red shows the melanin stem cells at the bottom of the hair follicles and the sympathetic nerves are shown in green around them. Therefore, the culprit behind Marie Antoinette Syndrome is adrenaline, but our problem is not over yet. Stress produces adrenaline which turns our hair gray, so can a silvery bangs help relieve stress? The team from Harvard University, led by Xu Yajie, believes that hair-whitening is actually a side effect of sympathetic nervous system stress processing: “For species like octopuses and geckos flowers have the ability to change color rapidly, the pigment cells in their body will be activated under the influence of the nervous system, but in today’s mammals, only melanocytes remain. very sensitive to the hormones secreted by the nervous system. Once the hormone is secreted in excess, these cells are inadvertently activated.” Gray hair color is not life-threatening, so in the process of evolution, this small defect has remained. In fact, in the face of stress, hair doesn’t actually turn completely white overnight, which is a slow process and lasts for several months. In addition to being associated with stress and age, gray hair can sometimes be related to experience, leadership, and trust. For example, when a male silverback mountain gorilla is fully grown, it will grow gray hair on its back and become the leader of the gorillas. After being subjected to enough pressure, individuals that are “dyed” white often have a higher status in the community than their age.

During the interview with Seventeen, members of the ITZY group shared the secret of daily skin care. Despite having a tight schedule and always having to wear heavy makeup, they still try to take time to care for their skin, drink plenty of water, and get enough sleep. Photo: Allure. Yeji share on Allure : “After debut, I have to wear makeup all the time. So I know it is important to take care of my skin.” Her skin care steps in turn are toner, essence, lotion, eye cream and lip mask. The ITZY team leader said lip balm is an important item that she always carries with her. Image: Kpopping. Lia Great attention to skin care and items used. She says her skin is sensitive to most beauty products. “It’s really hard to keep my skin in good condition if I have to wear a lot of makeup,” Lia said. Image: Itzy pics. Initially, Lia applies a 10-step skincare cycle to overcome blemishes. “I searched a lot of things and tried new products. Only a few of them really helped. So I focused on cleansing and moisturizing,” she says. Photo: Naver. Different from Yeji and Lia in terms of skin care, Ryujin said she only drinks enough water every day to keep her skin hydrated. The rest of the members also acknowledge the benefits of water for the skin. According to the Skinkraft, Drinking enough water helps maintain skin pH, prevents acne and premature aging. Image: Uhdpaper. In the interview with Seventeen , Yuna revealed that she always tries to take care of her eyelashes with specialized products. According to the Byrdie , women can use eyelash growth serum or nourish with coconut oil every night to have thick and long lashes. Image: Pantip, Kpopnchill. While, Chaeryeong cleaning is preferred. “I have a lot of facial cleansing products in forms like creams, foams, gels …”, she said. In addition, Chaeryeong also regularly changes the pillow cover to limit the face skin contact with bacteria. Image: Kpopping.

Chemotherapy Illustration. Not all chemotherapy causes eyebrow hair loss. There is usually a standard protocol that if you don’t lose your hair, you will lose your eyebrows. Infection If you have a fungal infection, scabies, syphilis and leprosy, your eyebrows will fall out from scratching a lot. Autoimmune disorders This causes hair loss all over the body, including the eyebrows. Immune disorders that cause brow loss include symptoms like lupus that can cause thinning of eyebrows and hair loss. Vitiligo can sometimes cause inflammation that is severe enough to cause hair loss and hair loss. In general, eyebrow hair loss often occurs with other symptoms more severe when lupus and vitiligo visit. Onions and honey to thicken eyebrows In onion contains a lot of sulfur, a compound that stimulates hair growth, enhances blood circulation very effectively. Honey contains many important vitamins that support the growth of eyebrows. Materials need to prepare: – 1/3 onions 1/2 teaspoon honey – Blender, sieve, bowl and spoon The ingredients you need to prepare Doing: – Onions peeled, washed, sliced ​​and then put in a blender, puree. Shred the onions to make this recipe – Use a sieve to remove the residue, separate the juice to the bowl. – Pour honey into a bowl and use a spoon to stir until a homogeneous mixture is obtained. The mixture after being obtained has a viscous form. Using: – Clean the eye area with warm water to enlarge pores, pat dry with a soft towel. – Use a cotton ball to dip in the mixture above, apply evenly over 2 rows of eyebrows from base to tip. Save the mixture overnight, rinse with cold water the next morning. Apply this method 3 times / week, after only 2 weeks, your eyebrows are both thicker and longer than seen.