BioNTech Annual General Meeting Vaccine effective against mutants

Status: 06/22/2021 6:13 p.m.

BioNTech boss Sahin uses the vaccine manufacturer’s general meeting to spread good news: Production will be increased and the vaccine also protects against virus variants. In view of the growing spread of the delta variant of the coronavirus, which is considered to be more dangerous, many people are wondering how the effectiveness of the various vaccines is doing in this regard. At today’s Annual General Meeting, CEO Ugur Sahin gave the all-clear for BioNTech’s product: “There is currently no evidence that our vaccine needs to be adapted to the variants in circulation,” he said. That does not mean that the company is stopping development: According to Sahin, BioNTech is working on flexible processes in the areas of technology, production and approval.

Constant analysis

In order to be prepared and to be able to react quickly if a third dose should be required to boost existing vaccinations or to adapt to a new virus strain, BioNTech constantly analyzes the effectiveness of the vaccine against newly emerging variants, the CEO explained.

Sahin also commented on the subject of booster vaccinations: It is not yet known when and how often a booster will be necessary. But he assumes “that a third vaccination is of great value for boosting immunity,” said Sahin. Knowledge about the corona virus is steadily increasing. “We observe that immunity will decrease over time and new variants will emerge.”

Sahin against patent release

The one raised by US President Joe Biden and other politicians Request for the release of patents to enable license-free vaccine production in developing countries, the BioNTech boss rejected. It is important to be able to make the vaccine available worldwide “as quickly and as comprehensively as possible”. However, raw materials are currently the “limiting factor”, not patents.

BioNTech is working with partners to deliver the vaccine cheaply to developing countries. However, a patent release would not bring additional amounts of vaccine. The production of the vaccine is very complex and consists of around 50,000 work steps.

Production is increased

During the Annual General Meeting, Sahin also commented on production: The BioNTech boss confirmed that the company, together with its US partner Pfizer, is aiming for a production capacity of up to three billion vaccine doses this year.

In the coming year 2022 it should be more than three billion. BioNTech will manufacture at least half of this. To date, BioNTech and Pfizer have shipped more than 700 million doses of their Covid-19 vaccine to over 100 countries worldwide.

Dividend is possible

The shareholders should also benefit from the billions in sales generated with the corona vaccine. Chief Financial Officer Sierk Poetting said that in the next financial year it should be checked whether and in what amount a dividend is possible.

However, the strategic priority for 2021 is the reinvestment of the capital in order to further advance innovations in various therapeutic areas and technologies as well as our corporate development, said Poetting. The Mainz biotechnology company achieved a net profit of 1.1 billion euros on sales of 2.05 billion euros in the first quarter of this year .

New production facilities

There was also news from BioNTech outside of the Annual General Meeting. The European Medicines Agency’s Committee on Medicinal Products for Human Use gives the go-ahead for two more production facilities to manufacture the joint corona vaccine from Biontech and Pfizer.

One becomes accordingly in Reinbek, Schleswig-Holstein, operated by Allergopharma, the parent company of Dermapharm , the other in the Swiss stone from Novartis Pharma. The work can be started immediately, since no approval from the EU Commission is required

Professor, Doctor of Science Tran Duy Quy, Director of the Asia-Pacific Institute of Science and Technology Cooperation and Chairman of the Vietnam Orchid Association, said the above price is not virtual. “With mutant orchids such as: Lan Vinh Khang, Dai Cat, Ngoc Son Cuoc…, if you achieve all the strictest elements of a beautiful orchid, the price will fluctuate from 1-10 billion VND/cm kie. (seedlings develop from the eyes of the mother plant)”, Mr. Quy said. How much does a mutant orchid cost? “There is no set price for mutant orchids. The expensiveness of a mutant orchid depends on the rarity and beauty of each plant,” Quy said and said that there are about 35,000 species of orchids in the world, about 1,010 species in Vietnam alone, while mutant orchids have about 100 varieties. According to the professor, not every mutation will be expensive. There are mutant orchid varieties costing only a few tens of thousands of dong such as: Hac Vy Trang, Phi Diep Trang… These are popular orchids in the playing community and market, easy to find in nature, widely propagated. cobble. Orchid currently has about 35,000 different types in the world. Photo: Hainan. Meanwhile, Dai Ngan Butterfly, Juliet, Ngoc Son Cuoc, Pleiku Eyes… are some mutant orchids with very expensive market prices. The reason explained by Mr. Quy is that these orchids are created by nature over millions of years, and at the same time, the flowers that grow from these orchids reach perfection on very strict criteria. As an example of the white 5-petal mutant orchid Phu Tho, the President of the Vietnam Orchid Association said this orchid was found by a Central Circus in 1972 in Phu Tho. Then, they hand it over to the indigenous people to cultivate. “Currently, there are five white-petaled white berries in Phu Tho that are valued at 400-500 million VND/cm. But to have this price, the flowers from the tree must be perfect,” said Mr. Quy. Specifically, the tree structure must be clean – green (ie, no stains, no other colors); cotton must be pure white or clear as jade; horizontal “shoulder” – “wing” gourd; “eyes” are scratched like a girl’s eyelashes or must be very dark; hairy “lips”; The distinctive and special seductive fragrance “nose” must be so clean and white as snow. The “parts” of an orchid. Photo: HN When meeting the above criteria, according to Mr. Quy, a 5-petal white Phu Tho orchid can be sold for hundreds of billions of dong, depending on the height of the tree. “There are flowering mutant orchids that achieve all the requirements such as horizontal shoulders, gourd wings, fragrance… But if the nose of white flowers will cost a few billion, the nose of other crops will only be a few hundred thousand.” Mr. Quy shared. The professor said that currently, Vietnam has no council or agency or organization that accepts responsibility for pricing orchids. The price will be evaluated and given by the people in the playing community. The more people rate beautiful flowers, the higher the price. Therefore, recently, when the spread of orchids “bloomed”, the demand for orchids increased dramatically, leading to the price of orchids being “blown” higher than the real value. Mr. Quy said that this situation will decrease and end when the sudden supply of orchids balances with demand. Being deceived because of cheap greed, gullible gullibility According to the President of the Vietnam Orchid Association, there are two types of mutant orchids, natural mutations and artificial mutations. Natural mutation is a change in the nature of genes but occurs naturally, accumulated over millions of years and selected by nature, retaining the essence. Humans when finding this natural mutant will often use and propagate it. At the same time, the natural mutant orchid lines will have a very expensive price because of its rarity. Meanwhile, artificially mutated orchids are essentially changes to the plant’s genome but are influenced by humans. This has the disadvantage that the mutation in the gene can disappear and return to the original form (due to rapid artificialification, the gene structure is not stable). In addition, artificial mutations also have a very low probability of success, depending heavily on luck. “Artificial mutant orchid creators often orient mutations according to inherent standards such as horizontal shoulders, gourd wings, clean nose… But the results are rarely perfect, successful mutations but not recognized”, Mr. Quy shared. In the picture is kie lan (seedlings develop from the eyes of the mother plant). Photo: Hainan. Talking about the situation of scams when transactions spread suddenly recently, the professor said that people who are deceived are often greedy, inexperienced and gullible. “Scammers often use social networks to advertise. They take pictures, attach the name of mutant orchids and then sell them. These scammers often never dare to publicly disclose the exact name or address of the garden.” Mr. Quy commented when talking about transaction frauds spreading through the network. As for many cases, the victims went to the garden to see the mutant orchids with their own eyes, but when they bought the kies, they discovered they were cheated, Professor Quy said that the buyers were inexperienced. “It is not possible to detect or distinguish mutant orchids from normal orchids through kies. All kies are the same, only when flowering will they know if it is a mutant orchid or not,” the professor recommended. Experts give advice when dealing with orchids that need a paper contract, must find reputable places, come to the garden to see the tree and have the testimony of many people.

As of 7am on May 11, related to the National Hospital for Tropical Diseases 2, there were 89 Covid-19 cases, of which 78 were at the hospital, 23 were Hanoians and 55 were at other hospitals. other province. Previously, as the new Han Newspaper reported, on the afternoon of May 9, the Ministry of Health announced the results of gene sequencing of the National Institute of Hygiene and Epidemiology on 8 samples of patients with Covid-19 in 3 provinces and cities. streets: Hanoi, Hung Yen and Thai Binh. As a result, all 8 samples belong to the Indian variant B1,617.2. Step 1: Visit https://www.bluezone.gov.vn or download directly at App Store or CH Play. Step 2: Once downloaded, the application will ask for permission to use Bluetooth to record contact with other Bluezone installed users. If Bluetooth is not open, drag the status bar and turn on Bluetooth; or go to Settings, select Bluetooth and turn it on. Step 3: Once the installation is done, click Scan Around. If someone near you less than 2m has used Bluezone, the application will automatically identify these users and put them in the contact list.

According to posted information, one beauty specialist With the nickname on the social network Tiktok, Minke328, recently uploaded pictures and videos of him handling his chapped, chapped feet like the ground with long drought, attracting attention great online community. The client’s feet suffer from epidermal keratosis, which many people cannot help but shiver. Where this customer has hardened leg skin Specifically, the epidermis on the soles of the feet is extremely thick, opaque yellow, and is heaviest in the feet and heels. Worth mentioning, this epidermis turns horny and then cracked, looking creepy at first glance, like a mutant of the land in science fiction movies. To handle the problem, the Minke 328 used a specialized knife to cut the skin of the keratinized skin, thinning the dead epidermis. After the processing process, many epidermal debris piled up, indeed making the viewer not afraid and shiver. It is known that after being processed, the customers are extremely satisfied, not only more comfortable but also feel relieved and healthier. This beauty expert said that he mainly helps clients with skin problems such as feet, wax, and nails, mainly diseases (Paronychia) – a common infection under the surrounding skin. nail. Minke328 also regularly posts the treatment process on the social network Tiktok, attracting more than 3 million fans, watching. As reported by Good Morning Health, external irritation and dryness are the main causes of thickening of the skin, when the skin is stimulated by these effects, the epidermal tissue begins to trigger a defensive response to protects the feet and causes keratosis of the skin, significantly thickening.

It happened in early 2018 at the Oregon College of Health and Science in Portland, Oregon (USA). 26-year-old medical student Warren Nielsen and four friends in the group prepare to perform the surgery of the donated body in the autopsy room. The body that the Nielsen group operated on was that of Rose Marie Bentley, who died in 2017 at the age of 99. Rose died of natural causes, not illness or accident. Before her death, she expressed her wish to donate her body to medicine. The woman with visceral reversal and was the longest living person with the condition ever recorded. But as soon as she operated the donated body of Mrs. Bentley, Warren Nielsen and his group were very shocked. They felt something was very strange because what they saw seemed completely contrary to the theory learned in the syllabus. “ I know something happened, but it took us a while to determine the composition of her organs “, says Cameron Walker anatomy professor at the Oregon College of Health and Science. “ Bentley’s veins are on the left side, instead of pouring directly into the heart. Her veins continued across the diaphragm, along the thoracic vertebrae, up and around on the aorta before pouring into the right side of the heart. Our normal bodies are never like that “, Walker explained. A live image of Mrs. Bentley. It was not the only anomaly that surgeon Cameron Walker and his students found in Mrs. Bentley’s body. Her right lung had only two lobes, instead of the usual three, while her heart’s right atrium was twice the size of normal. A series of questions were asked: Why is Mrs. Bentley’s stomach on the right side and not the left side? Her liver is on the left, not the right side? Likewise, is the spleen on the right side instead of the left and organs that should be in the abdomen found in the chest cavity? And there are many other abnormalities inside the body, including part of the stomach protruding from the diaphragm and strange veins … Why? The cause of Bentley’s internal upheaval may come from a congenital condition called Situs inversus – in which most of the vital organs are reversed, almost like a mirror inside the body. The picture shows abnormalities in the internal position of Mrs. Bentley. That, along with a host of other bizarre anomalies, make Mrs. Bentley a “mutant” and it will make her name recorded in the history of world literature. This strange mutation can occur between days 30 and 45 of pregnancy, he added, but no one knows why. It is estimated that for every 10,000-22,000 births, only one will experience Situs inversus. Due to heart defects, only 5% to 13% of those children live beyond the age of 5 years. Records have been documented in a boy who lived to the age of 13 and one who lived until the age of 73. The reversal of the internal organs will affect the health of the person who has it, so the majority of children with Situs inversus do not survive to adulthood. So the fact that Mrs. Bentley lived to the age of 99 is almost an unbelievable miracle. Mutants with normal life Photo: Internet Mrs. Bentley has 5 children, 14 grandchildren, 31 great-grandchildren and 11 children, but no one, not even the 99-year-old old lady, knows about the strange mystery inside her body. Louise Allee, one of Mrs. Bentley’s five children, shared that her mother was a lover of science. Perhaps that is the reason why Mrs. Bentley decided to dedicate her body to research. “ My mom will think that’s a great thing she can do. She will smile in heaven when she learns about her difference, especially when the difference is so meaningful. “Said Louise Allee. An image of a young Mrs. Bentley. “ Despite suffering from chronic heartburn (possibly due to the abnormal stomach position) my mother never complained of any discomfort in her body. We have no reason to believe there was such a strange thing in my mother’s body. My mother is always very healthy. She often took us to Campfire Girls, fishing, swimming. My mother deserves to be a great swimmer “Mrs. Bentley’s third child, Ginger Robbins, said. In fact, there was a time when a doctor was unable to locate the appendix for Mrs. Bentley. At that time, the doctor only noted the family that her appendix was in an unusual position. The doctor also did not check on other organs, so things gradually went into oblivion.