CureVac vaccine not very effective Crash of a Bearer of hope

Status: 06/17/2021 12:31 p.m.

CureVac’s vaccine proves far less effective than hoped, with the biotech company’s stock plummeting. What does this mean for the vaccination campaign and German taxpayers?

From Angela Göpfert, tagesschau.de

For the company CureVac and its owners, dramatic scenes have taken place in the past few hours. The price of the Tübingen-based company listed on the US technology exchange Nasdaq had already halved in after-hours trading on the US stock exchange on Wednesday. This morning, the CureVac share then rushed in German retail by up to 52.4 percent.

Eight billion euros destroyed on the stock exchange

This destroyed around eight billion euros in market value within a few minutes. This melted down from over 15 to a good seven billion euros. The drastic course reaction shows how surprisingly, despite all previous doubts, such devastating study data as CureVac has now presented, came in the end – and how serious the consequences could be.

On Wednesday night, CureVac announced that its first-generation vaccine candidate was CVnCoV only an effectiveness of 47 percent against a Covid 19 disease of any severity. The company thus missed the intended statistical success criteria for approval.

Completely out of the vaccination campaign?

The study is to be continued, and the degree of effectiveness could change with higher case numbers. However, if the current trend continues, approval is unlikely. In this case, experts say CVnCoV would be a total flop for the company. For the German vaccination campaign, CureVac is therefore canceled until further notice. “According to these study results, it will be extremely difficult for CureVac to play a role at all in the current vaccination campaign”, told LBBW analyst Timo Kürschner tagesschau.de . According to the federal government, the setback for the Tübingen company does not upset the vaccinations in Germany. “This announcement has no effect on the speed of our vaccination campaign”said a spokesman for the federal health ministry.

Other manufacturers are still catching up

Industry observers believe that speed is just as important in vaccine development as it is in drug development. “Late bloomers like CureVac only have a chance if they have a better effect profile or fewer side effects”, explains pharmaceutical expert Kürschner.

“The more time that elapses, the more efficient the production of vaccines that have already been approved will be”says the pharmaceutical expert. “BioNTech & Co. are then more and more able to serve the required delivery quantities.” His conclusion: “We could get to a point where you actually no longer need the CureVac vaccine because the vaccination campaign is already so advanced.”

Hundreds of millions from the federal government

The severe setback for CureVac meanwhile has effects beyond the current vaccination campaign. It meets the German taxpayers – after all, the federal government has a stake of around 16 percent in the company and has supported vaccine development with a special program worth several hundred million euros. It is also a debacle for SAP co-founder Dietmar Hopp, who holds almost 50 percent of the shares.

Last but not least, the CureVac price disaster hits the countless private investors who have invested their money in the share. The paper of the company, which is legally based in the Netherlands, has been one of the most traded foreign stocks in the past few weeks on the Stuttgart Stock Exchange, where many private investors cavort.

Recently increased warning signs

Recently, there had been more and more indications that the CureVac vaccine could fail for the time being. Even when Health Minister Jens Spahn, according to media reports, deleted CureVac from the federal government’s planning for the current vaccination campaign, this could hardly affect the share.

The high market capitalization compared to rival companies was also a warning sign: Before the current price crash, CureVac had a higher market value than Novavax. The US manufacturer had already reported a Phase III study on Monday, according to which its vaccine had a has a high effectiveness of 90 percent .

Often high risk in the industry

For CureVac and its owners this is now the “Worst case” of a biotech company. At the same time, the CureVac case also shows the general risks facing the industry. Companies in this industry usually have very few active ingredients in their pipeline. If one then fails – for whatever reason – it often has fatal consequences for the entire company.

LBBW expert Kürschner also sees CureVac “a prime example of the risks involved in investing in biotech companies”. However, Kürschner does not fear negative consequences of the CureVac events for the German biotech industry. After all, there is a positive counterexample in the country. “I’m sure: BioNTech’s success story will outshine the rather negative course at CureVac.”

The beauties used to be labeled “mobile vase” on the screen. In Vietnam, Ngoc Trinh is a toddler entering the 7th art as a model, a famous hotgirl, inexperienced and quite young. At first, the audience glanced curious, curious at her, eagerly waiting to see what a “lingerie queen” could do when encroaching on the big screen. Ngoc Trinh is also not considered a gifted actor. But when transforming into the character, the beautiful Tra Vinh gradually captured the sympathy of the audience by her natural, simple acting with a bit of “banh beo”, as lovely as her true self. Gradually, people realized the maturity and progress of Ngoc Trinh through each role, only to nod in appreciation that her acting skills were indeed “not medium”. His first role brought himself to the big screen When she first hit the cinema lane in 2016, Ngoc Trinh was given a leading role in the film Waist 56 . Under the shaping hands of director Vu Ngoc Dang, a beauty born in 1989 caused controversy when she chose to put her own life on the big screen. The 56th waistline follows the character Trinh (played by Ngoc Trinh) – a girl from a poor country family in the southwestern region. Because they wanted to repay their parents’ debts, both Trinh and her siblings all asked to go to Saigon to work to earn money. Since then, Trinh accidentally fell in love with a modeling job – her dream since childhood. Although at this time, Ngoc Trinh does not have much acting experience, but her performance did not disappoint the audience. The beauty is appreciated for the natural, comfortable performance required by a professional actor. Along with that, perhaps because of the role that simulates her own life, Ngoc Trinh is quite well transformed, not making the audience feel the drama or “the audience cherishes”. Since then, movie-loving audiences began to see Ngoc Trinh with a different eye. A big breakthrough with Vu big chaos Despite being evaluated quite well after her first role, Ngoc Trinh is still a name that makes filmmakers consider a lot when choosing her as the main character. Therefore, it was not until 3 years later that she was invited to the next project with a landmark role in Vu Quy great chaos . In the film, Ngoc Trinh and Dieu Nhi transform into Trang and Hien – two close friends who have reached the age of adolescence. Under pressure to get married from their parents, both invited his friend Hoang (La Thanh) to join, and left home to go to dust. But going to dust exams must also have money to spend, not worry about starving to death. With business blood in her, Trang decided to set up a team specializing in wedding planning. With the help of Aunt Hai’s wedding with the dumb-faced singer Tai, the group began to work extremely smoothly. But every joy will end, at the last minute, will Trang and Hien find the true destination of their life? Belonging to the psycho-emotional genre, humor, Vu Quy great chaos has received many compliments from the audience when he debuted. In particular, playing the central character in the film, Ngoc Trinh proved not to be inferior to the stars from veteran to “professional people” in acting such as Viet Huong, Chi Tai, Dieu Nhi, La Thanh, … . This time, Ngoc Trinh was praised for her full role, a good transformation into a character with a completely different fate from herself. There is no reason for the audience to deny Ngoc Trinh’s efforts and a long success in acting field. The first time encroaching on the small screen If you pay close attention, the original shape of Ngoc Trinh from Waist 56 to Vu Quy great chaos All are images of an innocent “banh beo” girl, what to say to her from a peaceful and poor countryside. Undeniably, despite being beautiful and rich in real life, the “lingerie queen” is still very suitable when transforming into this character. However, it seems that Ngoc Trinh is not so crucified in one kind of role. Earlier this year, the beautiful Tra Vinh determined to “land” the small screen with the lead role in the first TV series – The mother learns to love . This time, the actress is not afraid to change her image completely as a single mother, having to take care of her children alone. That is Bang Di – a strong, modern girl with an extremely liberal concept of love. Ironically, she took on the responsibility of raising her 6-year-old son. Her life suddenly turned upside down when she both managed to be a single mother and struggled in a troubled, troubled love four. This time, Ngoc Trinh has completely shown her maturity through her role. Without the innocence and gentleness of a teenage country girl, her character now has the strong, sharpness of a modern woman. At the same time, the role does not simply bring a sense of joy, lightness or humorous laughter to the audience, but also contains inner tensions and entanglements in the character, requiring actors to have understanding. understanding, certain feelings about fate incarnated by themselves. Accepting the invitation to join this special role, Ngoc Trinh challenged herself to a new position – the role of a professional actor. It is difficult to say whether this role is truly excellent, capturing the hearts of the entire audience or not, but one thing is for sure that Ngoc Trinh has been seriously pursuing the path of acting. And her dedication and dedication to her role, despite her image, deserves to be recognized by the audience. After The mother learns to love At the end, Ngoc Trinh has not revealed new plans and projects in the film. Hopefully in the future, “the queen of underwear” will continue to return with many attractive roles, proving herself as one of the beautiful flowers of all colors – the scent of the Vietnamese entertainment industry.

Everyone knows that being a mother is a sacred ministry, an infinite happiness for a woman. But frankly speaking, on the journey of 9 months 10 days pregnant, for many people, that feeling of happiness “has not appeared”. Instead, it was a wealth of hardships, fatigue, and physical changes.

For example, for the first time, mothers have to experience morning sickness, discomfort when smelling things that smell and vomit. Then the body began to gain weight, getting heavier and heavier. From about the last 3 months of pregnancy until about to give birth, there continue to be other changes that make pregnant mothers extremely tired.

Here are some of the symptoms that mothers experience when they are about to give birth. It is not at all pleasant at all, but it is showing that the baby in the belly develops healthy, pregnant mothers need not worry too much:

Tension in the abdomen

In the months leading up to the birth, mothers often feel a tight stomach, but it is not painful but quite uncomfortable. Next is the rule, on average 1 hour no more than 10 times there will be pain. This is a very common phenomenon of false contractions, pregnant mothers need not worry too much about it.

From about the last 3 months of pregnancy until about to give birth, there continue to be other changes that make pregnant mothers extremely tired. (Illustration)

The cause of this condition is that nearing the due date, the baby’s head begins to slowly sink into the mother’s pelvis to facilitate a correct and convenient delivery. The mother’s stiffness and spasmodic pains indicate that the baby is “moving on” the correct process to prepare for birth. It shows that the child is developing steadily, healthy

Increase the frequency of going to the toilet at night, to the point that pregnant mothers are afraid to drink water

Mothers who are about to become pregnant in the first and second trimesters also go to the toilet often, and this feeling becomes clearer after entering the third trimester. Because of this, many mothers are afraid to drink water. Even so, they urinate quite a few times during the day and cannot sleep well at night when they often wake up to the toilet.

This condition is also caused by the much larger fetus, pressing on the bladder, creating pressure that makes pregnant women often feel sad to urinate and the bladder cannot store much water due to the cramped space. the baby grows up.

Mothers who are about to become pregnant in the first and second trimesters also go to the toilet often, and this feeling becomes clearer after entering the third trimester. (Illustration)

Because of going to the toilet, pregnant mothers are lazy to drink water, it is not good at all. Mothers still have to make sure to drink enough water every day. But don’t drink a large cup right away, but split it up into several times to reduce frequent defecation.

Pain occurs in many parts of the body

Low back pain and pubic pain manifest most clearly in the second trimester. After the fetus moves to a position to prepare for birth, the mother’s pelvis will be under greater pressure, the fetus is low, and the mother’s pubic bone will also be more painful. But that is also the message sent by the fetus “I am going to see you soon”. Therefore, give yourself a little bit of this uncomfortable pain as it is a sign that you are about to give birth.

Increase the amount of secretions

During the third trimester of pregnancy, expectant mothers continue to increase progesterone, leading to more secretion of the mother’s body. However, this translation has normal color and texture. In the event of an unusual or unpleasant color or odor, you should check it promptly.

In addition, pregnant mothers also pay attention to whether the secretions are red or brown or not. If the discharge turns like this, the amniotic fluid is most likely ruptured.

Despite such unpleasant things, this is a sign of the healthy development of the fetus and the coming date of birth. Besides, pregnant mothers also have some things that are more comfortable in the last months of pregnancy.

Low back pain and pubic pain manifest most clearly in the second trimester (Artwork)

First of all, pregnant mothers find it easier to breathe when the fetus starts to fall deeper, leaving a wider upper space so it is easier to breathe.

Second, the space around the mother’s stomach is also more spacious in the third trimester due to the deep decline of the fetus, preparing for the birth process. At that time, pregnant mothers will have more appetite and eat more comfortably. However, mothers should also control eating scientifically, not to gain too much weight.

Finally, psychologically, when you know that your baby is healthy and about to be born and meet each other, the mother will feel happy, excited and comfortable dealing with some of these short-term discomfort.