Marie Antoinette syndrome is a phenomenon in which a person’s hair suddenly turns white (depigmentation). The condition’s name comes from the folk tale of French queen Marie Antoinette, whose hair is said to have suddenly turned white before her execution on October 16, 1793. People often assume that this syndrome is caused by pressure – perhaps this is most evident in the photos of the head of state before and after taking office. Compare President Obama before and after taking office, retiring. However, because the specific mechanism of graying hair has not been elucidated, it is not clear that 3 factors of aging, genetic factors and stress will affect gray hair to what extent. Recently, researchers from Harvard University published a study in the journal Nature that identified the mechanism by which rat hair turns gray prematurely under stress. The average human scalp has 100,000 hair follicles, and humans also have many different hair colors. Hair color is determined by melanocytes, which produce melanin that absorb light in various combinations. Melanocytes are derived from melanocytes (MeSC), located in the protruding part of the hair follicle. The hair growth cycle is divided into three phases, namely the anagen growth phase, the catagen resting phase, and the telogen long metabolic (shedding) phase. Hair growth cycle: growth phase, resting phase and shedding phase (from left to right). Melanocytes are produced during the growth phase. As a person ages, the melanin stem cells will gradually deplete, and the pigment produced will have a “salt-and-pepper” color, then turn gray, and finally white – the pigment is completely lost. in all hair follicles. At first, researchers suspected that stress would trigger an immune attack on melanin stem cells. But this was later proven to be a false hypothesis, as the mice lacked immune cells but remained mutated and had white spots. Stress increases the secretion of the hormone cortisol, so researchers are beginning to suspect that the hormone cortisol is responsible for the hair color change. However, when the cortisol-producing glands were removed in the mice, the mice’s fur would still turn white. Finally, the scientists focused on the sympathetic nervous system, the system in the body that is used to control the stress response in dangerous situations. Through studies, scientists discovered that melanocytes are located in the bulging part of the hair follicle, surrounded by neurons of the sympathetic nervous system, and release a neurotransmitter molecule. nerve is called norepinephrine. Melanin stem cell activity under normal and stressful conditions. As can be seen in figure a, under normal conditions, melanin stem cells (MeSCs) migrated from the bulge (in the direction of the red arrow) and differentiated into melanocytes during the analysis. From there, melanocytes synthesize pigment to make the regenerated hair dark. During the degenerative and resting phase, these stem cells begin to die. However, in the next growth phase, there will still be a large amount of new MeSC used to replace the dead stem cells. In figure b, the researchers found that external pressure stimulates and activates the sympathetic nervous system, increasing adrenaline release in the hair follicles. Norepinephrine then causes the MeSCs to completely transform into melanocytes, and none of the stem cells survive the growth phase in the next cycle. Since no new melanocytes are produced, the hair is naturally greyish white. The researchers also tested the effects of different pressures on the fading of the mice’s fur. At different stages of hair growth, they exposed the mice to three different stressors – pain, limited mobility, and psychological stress. All three of these factors induce MeSC depletion, which eventually leads to the appearance of white hairs. Previous popular theories believed that stress-induced hormonal changes (such as corticosterone) or autoimmune reactions were responsible for graying hair. The researchers examined these underlying mechanisms, first by blocking corticosterone signaling, and then by stressing the mice’s immune systems. In either case, corticosterone changes or autoimmune responses did not induce MeSC depletion. However, the researchers found that the expression of MeSCs depends on an adrenaline receptor, which responds to adrenaline. The adrenal glands are the main source of adrenaline. But surprisingly, the researchers found that removing these glands still did not prevent the mice’s coat color from turning gray under stress. Another source of adrenaline is the sympathetic nervous system (SNS), which is active in response to stress. The researchers demonstrated that the bulge area is internally connected by sympathetic neurons. Using neurotoxin molecules to destroy the SNS or prevent sympathetic neurons from releasing adrenaline could prevent hair from turning gray due to stress. Next, the researchers studied mice with activated sympathetic neurons and found that over-activating the SNS in these mice could cause hair to turn gray without stress. Taken together, these results indicate that adrenaline released from activated sympathetic neurons induces MeSC depletion. The red shows the melanin stem cells at the bottom of the hair follicles and the sympathetic nerves are shown in green around them. Therefore, the culprit behind Marie Antoinette Syndrome is adrenaline, but our problem is not over yet. Stress produces adrenaline which turns our hair gray, so can a silvery bangs help relieve stress? The team from Harvard University, led by Xu Yajie, believes that hair-whitening is actually a side effect of sympathetic nervous system stress processing: “For species like octopuses and geckos flowers have the ability to change color rapidly, the pigment cells in their body will be activated under the influence of the nervous system, but in today’s mammals, only melanocytes remain. very sensitive to the hormones secreted by the nervous system. Once the hormone is secreted in excess, these cells are inadvertently activated.” Gray hair color is not life-threatening, so in the process of evolution, this small defect has remained. In fact, in the face of stress, hair doesn’t actually turn completely white overnight, which is a slow process and lasts for several months. In addition to being associated with stress and age, gray hair can sometimes be related to experience, leadership, and trust. For example, when a male silverback mountain gorilla is fully grown, it will grow gray hair on its back and become the leader of the gorillas. After being subjected to enough pressure, individuals that are “dyed” white often have a higher status in the community than their age.

In 2017, it was reported that the AI ​​had beaten the leading Go player in the world. Compared to chess or chess, go is characterized by a wide table with long moves, depending on the situation that the value of the stone (chess piece) changes. “Don’t lose to AI” is the opposite of nature Applying the same approach to chess as “memorizing all moves, calculating the most appropriate move” is difficult. Therefore, it was thought that the ability of computers to win against humans was in the future. However, AlphaZero, a Google DeepMind software released in October 2017, has become very powerful by deliberately self-learning rather than using data as gameplay profiles of previous players as models. . Moreover, not only Go but AlphaZero can play other games as well. Computers have gone away from human hands, can learn and grow up on their own. AI has evolved at such an amazing rate. Ray Kurzweil, who has authority in the field, says that 2045 will be the time to reach the “Technological Singularity”. Artificial intelligence will surpass human intelligence and the world will have big changes. Discussion about what to equip yourself to avoid being robbed of jobs by AI, to prepare in advance what you can do and AI is not spreading. However, for me that is not realistic. Predictions of “things the AI ​​can’t do” can also be overturned. Just by looking at the current rate of evolution, we can also confirm that a transformation beyond the ordinary human imagination will inevitably happen. Therefore, the mindset “Just trying to learn things that AI cannot do” will only create risks without enriching people’s lives. “Living and treating not failing with AI as the goal” is against the nature of the incident. Perhaps that is to give AI a human life. Whether AI or not, the story of “whether I live my life deeply or not” is the most important thing. To deepen humanity, I think it makes a lot of sense to read books about AI, predict the future. Surely you will be able to enrich humanity by deepening your thinking with books like “If AI possesses intelligence over the human brain, things like exchange information in a way. very ‘human’ is probably going to be a simple matter. If so, what will help man to become more ‘human’? What will he be pursuing from man? “. “If artificial intelligence had a reason beyond the human brain, would the expressions expressing the ‘human’ nature still be simple? If so, what will help people become more ‘human’? What am I going to pursue in human? ”, Surely you will enrich the human life. AI has evolved amazingly. Photo: in.springboard. For the human future We humans are “Homo sapiens = wise people”. Being able to share wisdom with others and pass it on to the next generation is the great point of Homo sapiens. If you go to a bookstore or library, the ancient East-West wisdom will fill in a narrow place. Great people have spent their whole lives searching for the truth or devoting themselves to sublimating in literary form, archived in book form, and can be read by anyone. Therefore, humans can make wisdom to progress. If you just talk to your family and friends, a monkey or a dog can do it too. Even ants are doing it too (they may not speak out loud, but they have a rich way of communicating). However, the animals and insects were incapable of knowing what people in other regions and eras were thinking. Not reading is a loss of pride as a “wise man”. If the capacity to concentrate weakens and man not only “does not read” but becomes “unreadable”, the future of mankind will no longer be bright. Again, I’m not saying that the Internet and the social network (SNS) are bad. These amazing tools are also something born of human intelligence. The point is to use them appropriately. However, it’s a waste to get completely bogged down in it and forget the joy of reading. Reading is a privilege to be enjoyed. It is also the most wonderful thing that can deepen our life. I think it is in the golden age of the Internet and today’s social networking, to once again focus on reading is essential.