Debate about opening times Shop on Sundays until Christmas?

Status: 19.06.2021 2:58 p.m.

Brick-and-mortar retail suffered a lot in the pandemic, while online retailing gained tremendously. DIW, Städtebund and the trade association HDE are now calling for more flexible opening times to help stimulate the economy. The union ver.di warns. The President of the German Institute for Economic Research (DIW), Marcel Fratzscher, calls for opening hours to be relaxed in view of the difficult situation of many retailers. “A liberalization of the shop opening times is urgently required so that the stationary retail trade can assert itself in the competition against the online trade and secure jobs,” said Fratzscher to the “Handelsblatt”.

Flexibility required until the end of the year

The economist stood by the side of the trade association HDE. He had suggested leaving the shops open on Sundays at least until the end of the year. This gives retailers the chance to make up at least part of the sales lost during the lockdowns and would also be a signal to people that the city centers are open again. In addition, there should be more reliable rules for a legally secure occasional Sunday opening.

The Association of Towns and Municipalities also spoke out in favor of it. “We now have to do everything we can to ensure that our inner cities and town centers do not become deserted,” said managing director Gerd Landsberg to the “Handelsblatt”. “It would be a positive signal to allow additional Sunday opening hours.” Landsberg referred to the threatening situation of the trade and the danger for hundreds of thousands of jobs.

“Small but important signal”

Over 100,000 retail stores could close or not open at all, Landsberg said. This would put almost 500,000 jobs at stake. The online trade, on the other hand, was open 24 hours a day, seven days a week, and was able to increase its sales to over 72 billion euros last year due to the pandemic. Additional Sunday opening hours would therefore be “a small but important signal that the city centers and town centers have a future”.

“Development cannot be reversed”

Fratzscher explained: “Due to the pandemic, there was a massive shift towards online trading, which will not be completely reversed even after the pandemic.” However, fair competitive conditions did not mean that people could shop online 24 hours a day, seven days a week, but stationary retail trade had a “tight corset” and had to be closed on Sundays.

“Instead of sanctions or charges for online trading, politics should make stationary retailing more attractive,” said Fratzscher. In addition to more flexible shopping times, this also includes modern urban concepts that make inner cities more attractive again. “This not only has an immediate economic value, it is also very important from a social and societal perspective that people meet and come into contact with one another.”

Ver.di sees “general attack”

The FDP already supported the HDE’s advance as a suitable economic aid for the retail sector. The trade union ver.di, on the other hand, rejected him as an overly short-sighted “general attack on the trade workers, their families, but also on the Basic Law”.

The striped fish is a catfish with scientific name (Pangasius macronema), this is a fish with high economic value in the market. Photo: Le Hoang Vu. In the framework of the Science and Technology project, a group of researchers from the Faculty of Fisheries (Can Tho University) and graduate student Tran Dong Phuong An, for the first time successfully artificially reproduced freshwater striped fish. The striped fish is a catfish with scientific name (Pangasius macronema), this is a fish with high economic value in the market. Currently, this fish species occurs in the wild quite few and concentrated in provinces such as An Giang, Dong Thap, Vinh Long and Can Tho city. In order to develop the economy, recently, many farmers in some provinces in the upstream of the Mekong River have caught fish in the wild and brought back to raise them in rafts on the Tien and Hau rivers with industrial food for sale. commodity. Currently, striped fish is sold in the market at a high price of 120,000 – 130,000 VND/kg, while in restaurants the price is from 250,000 to 300,000 VND/kg. For the first time, successfully artificially reproduced freshwater striped fish. Photo: Le Hoang Vu. According to the project team, after nearly 4 years of research, this is the first time to successfully stimulate artificial reproduction of striped fish and it is expected that this breed will be replicated and provided to farmers in 2023. This was approved by the City Department of Science and Technology. Sponsored by Can Tho.

Resources: – 500 gr of young ribs – 1/2 red bell pepper – 1/2 green bell pepper – 1 tomato – Crispy flour – Vinegar – Chili sauce – Minced garlic Making: Step 1: Chop ribs to taste, soak in dilute salt water for 5 minutes, then rinse with water. Let dry. Step 2: Marinate the prepared ribs with 1/2 teaspoon of garlic powder, 1/2 teaspoon of main noodles, 1/2 teaspoon of salt and pepper, 1/2 teaspoon of paprika if you can use it spicy. Marinate 5 minutes. Then, put the crispy batter into the shirt evenly. Step 3: Bell peppers and diced tomatoes are not too small. Step 4: Heat oil for the ribs and fry on low heat until the ribs are cooked evenly. Crispy golden ribs, then remove to drain. Step 5: Make sweet and sour sauce Put in a bowl 2 tablespoons chili sauce, 3 tablespoons vinegar, 2 tablespoons sugar, 1 tablespoon ketchup, 1 tablespoon oyster sauce, and half a cup of water. Stirred. Sauté garlic for the bowl of mixed sauce. Taste sweet and sour, just add a little diluted tapioca starch to thicken. When the sauce boils to a moderate consistency, add the bell pepper and tomato. Stir briefly and then turn off the stove. Step 6: Put the fried ribs in the sauce, stir well, put on a plate. Serve with hot rice. Finished Products: Crispy ribs are rich on the outside, soft on the inside, sweet and sour sauce stimulates the taste buds. According to the Star

As reflected in the name of TIM-3, current research on it is mainly focused on T cells. TIM-3 is regarded as a marker molecule of T cell exhaustion in chronic viral infection and cancer models[2].

Although multiple drugs targeting TIM-3 have entered clinical trials[1], but The mechanism of blocking TIM-3’s anti-tumor activity is still a bit vague Because TIM-3 is also expressed on many other immune cells, do immune cells other than T cells participate in its anti-cancer effect, or even play a more important role?

On June 9, 2021, the Vijay K. Kuchroo team from Harvard Medical School published important research results in the journal Nature. They found Blocking TIM-3 on dendritic cells (DCs) may play a more critical role in enhancing anti-tumor immunity [3]!

Screenshot of the paper’s homepage

In order to understand the specific functional mechanism of TIM-3, the researchers used a large number of conditional knockout mouse models.They found that in After knocking out TIM-3 in CD4 and CD8+ T cells at the same time, tumor growth was inhibited to a certain extent, but not very significant ;and Specific knockout of TIM-3 in CD8+ T cells, regulatory T cells or NK cells does not affect tumor growth .

This result is a bit surprising, but the researchers quickly thought, would TIM-3 on myeloid cells have a more important function?

The researchers found through single-cell sequencing combined with flow cytometry that High expression of TIM-3 in DC1s and migDCs (migDCs) in tumors .in After specifically knocking out TIM-3 in DCs, tumor growth was significantly inhibited, and This effect is stronger than TIM-3 knocking out T cells .

Knock out TIM-3 in dendritic cells (gene name is Havcr2), the tumor is significantly suppressed

So, how does TIM-3 on DCs affect the anti-tumor immune response?

With the help of single-cell sequencing results, the researchers found that after knocking out TIM-3 in DCs, the number of CD8+ T cells infiltrated in the tumor increased. A more detailed analysis found that Early activation, effect, memory, memory precursor T cells increased , These T cells play a key role in the anti-tumor immune response[4].

Streaming analysis also confirmed that in After conditionally knocking out the TIM-3 of DCs, the memory precursor CD8+ T cells and effector T cells infiltrated in the tumor increased significantly .

After knocking out TIM-3 of DCs, memory precursor CD8+ T cells (TCF1) and effector T cells (CX3CR1, T-bet, Ki67) increased

One of the main functions of DCs is to promote the anti-tumor immune function of antigen-specific CD8+ T cells through antigen presentation[5].Further analyzing the myeloid cells in single-cell sequencing, the researchers found Some genes related to MHC class I antigen presentation are significantly elevated .

Mouse experiments also confirmed that after knocking out the TIM-3 of DCs, the proportion of antigen-specific CD8+ T cells in the tumor was significantly increased, and it had a stronger killing potential.Description Inhibition of TIM-3 can enhance antigen-specific immune response .

After knocking out the TIM-3 of DCs, the proportion of antigen-specific CD8+ T cells increases and has a stronger killing potential

After studying the mechanism at the cellular level, the researchers began to further explore more detailed molecular mechanisms.

The researchers first analyzed the interaction between CD8+ T cells and DCs based on single-cell sequencing technology. The results showed that after knocking out the TIM-3 of DCs, the ligand-receptor interaction scores of Il18–Il18r1 and Il18–Il18rap increased significantly.Analysis of cytokines in tumor homogenate also found Significantly increased levels of IL-1β and IL-18 .

Friends who are familiar with inflammasomes must be able to think that inflammasomes mediate the activation and release of IL-1β and IL-18. Does knocking out TIM-3 activate the inflammasomes?

Pattern diagram of inflammasome activation[6]

Sure enough, analyzing single-cell sequencing data, the researchers found that in the TIM-3 knockout DCs, inflammasome-related gene characteristics were significantly enriched.

Inflammasomes can be activated by pathogen-related molecular patterns (PAMP) and damage-related molecular patterns (DAMP)[7]Since the research here did not involve pathogens, researchers naturally wondered whether endogenous DAMP (such as reactive oxygen species, oxidized lipids, and oxidized DNA) activated the inflammasomes?

Researchers found that in TIM-3 knock-out DCs, the enrichment level of oxidative stress-related gene characteristics was significantly increased, and flow analysis also confirmed Increased ROS levels in DC1s and mDCs .Furthermore, the researchers treated mice with tumors with antioxidants (N-acetylcysteine) and found that The tumor suppressor effect brought by knocking out TIM-3 is completely eliminated, and the increase in IL-1β levels in the tumor is also completely eliminated .

After knocking out TIM-3, the level of ROS in DC1s and migDCs increased

So, is the activation of the inflammasome pathway the reason for the enhanced anti-tumor immune response?

Researchers used three ways to inhibit the inflammasome pathway (inhibition of caspase1, inhibition of NLRP3 inflammasome, inhibition of IL-1β/IL-18, friends can check the above schematic diagram), and found The anti-tumor effect enhanced by knocking out TIM-3 completely disappears, and the function-enhancing effect of CD8+ T cells is also eliminated .

Inhibition of the inflammasome pathway can eliminate the immune enhancement effect of blocking TIM-3

Overall, this study found that compared to T cells, TIM-3 on DCs may play a more critical role in tumor immunity , This discovery has a certain subversive significance to people’s previous cognition.

The author analyzes the mechanism from the perspectives of cell function changes in the tumor microenvironment and changes in molecular pathways in DCs, but this article still leaves many unanswered questions.

For example, how does knocking out TIM-3 lead to increased levels of oxidative stress in DCs? In addition, the experimental evidence of the relationship between oxidative stress and inflammasome activation in this article is still weak. In this model, is it possible that the inflammasome may be activated by other factors?

How does the activation of inflammasome affect the function of DCs and T cells? Is it possible that TIM-3 may affect the function of DCs through other mechanisms?For example, in the latest issue of Immunity, Brian Ruffell and others believe that Blocking TIM-3 contributes to the activation of the cGAS-STING pathway in DCs, thereby promoting the anti-tumor immune response [8].

Although TIM-3 still has a lot to be studied, it is worth looking forward to that many TIM-3 antibodies have entered clinical trials, including some domestic drugs. It is hoped that these drugs can be marketed as soon as possible and benefit more patients.

references

1. Siddiqui I, Schaeuble K, Chennupati V, et al. Intratumoral Tcf1(+)PD-1(+)CD8(+) T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity. Jan 15 2019;50(1):195-211 e10. doi:10.1016/j.immuni.2018.12.021

2. Roberts EW, Broz ML, Binnewies M, et al. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. Aug 8 2016; 30(2):324-336. doi:10.1016/j.ccell.2016.06.003

3. Terlizzi M, Casolaro V, Pinto A, Sorrentino R. Inflammasome: cancer’s friend or foe? Pharmacol Ther. Jul 2014;143(1):24-33. doi:10.1016/j.pharmthera.2014.02.002

4. de Mingo Pulido A, Hanggi K, Celias DP, et al. The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake. Immunity. Jun 8 2021;54( 6):1154-1167 e7. doi:10.1016/j.immuni.2021.04.019

New Zealand has the most expensive housing market in the world. (Source: stuff.co.nz) According to Bloomberg Economics, real estate prices around the world is exploding strongly, from which the warning will form a real estate bubble unprecedented since the 2008 financial crisis. Based on the key indicators used in Bloomberg Economics’ calculations, New Zealand, Canada and Sweden are ranked as the top countries, respectively. Expensive housing market best of the world. Meanwhile, the UK and US are also near the top of the risk charts. Bloomberg Economics economist Niraj Shah says there are multiple factors contributing to the rise in home prices to unprecedented levels worldwide, including record low interest rates, massive fiscal stimulus packages, and massive bailouts. Backup savings can serve as a down payment, limited housing stock and expectations of a strong recovery in the global economy. Besides, the trend of working from home to avoid infection COVID-19 causing more people to need more living space and many governments giving tax incentives to homebuyers also increase the demand to buy houses. According to calculations by Bloomberg Economics, the ratio of price to rent and price to income will help assess the sustainability of housing price increases. Bloomberg Economics analyzes that even as risk indicators rise, with interest rates remaining low, lending standards generally higher than before, and macro-prudential policies in place, the cause led to the real estate market collapse is not clear. Mr. Shah said that in the coming period, it is likely that the real estate market will witness a cooling, not a collapse. As interest rates start to rise and other measures are put in place to protect financial stability, the property market will face an “important test,” Shah said.

Part of this 58-year-old male patient’s vision has been restored, allowing him to recognize, count, locate and touch various objects displayed on the table in front of him. (Photo: New York Times) According to research results published on May 24, scientists in Europe and the US have applied optical genetic engineering to treat a patient who lost vision due to an inherited disease of photoreceptors. 40 years ago. This involves injecting them directly into the patient’s eye, combined with stimulation for several months by wearing light-emitting glasses, which convert images into pulses of light printed onto the retina. A 58-year-old blind man was able to partially restore vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy. The patient, who lives in France, was diagnosed with retinitis pigmentosa (RP), a degenerative eye disease that affects the retina at the back of the eye and causes it to stop working, almost 40 years ago. year. However, several months after the treatment, he was able to recognize, count, locate and touch various objects with the treated eye while wearing a pair of light-stimulating glasses. The researchers say that although their findings, published in the journal Nature Medicine, are still in the early stages, their work could be seen as a stepping stone to targeted treatments. new target for people with RP (RP – a condition in which the cells in the retina that receive light are disrupted, which can lead to total blindness). It is the most common inherited eye condition, affecting around 1 in 4,000 people in the UK. The researchers used a technique, called photogenetics, to genetically alter cells in the retina so that they produce light-sensitive proteins called channelrhodopsin. The treatment, which is done by injecting an eye into one eye, activates the gene that codes for a channelrhodopsin protein called ChrimsonR, which senses amber light. The team also developed specialized goggles equipped with a camera to capture and project visual images onto the retina at amber wavelengths of light. The patient then trained for several months as the genetically engineered cells began to stabilize. Seven months later, the patient began to show signs of improvement in vision, the researchers said. The team also said their patients were “excited” after this first experience of partial vision. With the aid of the light-stimulating glasses, the patient was able to locate, recognize, touch and count objects such as notebooks, pin boxes and glasses on a white table in front of him. The researchers also read the patients’ brain activity using a technique known as an electroencephalogram. A tortoise is alternately raised or removed from the table, and the patient must press a button to indicate whether it is there or not. The results from the experiments show that patients can recognize with 78% accuracy. Although this type of optical genetic therapy may be beneficial in restoring visual function in people with RP-related blindness, more results from this trial are needed, the researchers say. clearer picture of the safety and effectiveness of this approach. José-Alain Sahel, lead author of the study from France’s Sorbonne University and the National Center for Scientific Research, said: “It is important that blind patients suffer from various types of neurodegenerative diseases. and functional optic nerve would likely qualify for treatment. However, the effectiveness of the treatment depends on the extent of the patient’s optic nerve degeneration. He said it will take more time to study this method before it can be put into practice. Quynh Hoa According to The Irish Times

Part of this 58-year-old male patient’s vision has been restored, allowing him to recognize, count, locate and touch various objects displayed on the table in front of him. (Photo: New York Times) According to research results published on May 24, scientists in Europe and the US have applied optical genetic engineering to treat a patient who lost vision due to an inherited disease of photoreceptors. 40 years ago. This involves injecting them directly into the patient’s eye, combined with stimulation for several months by wearing light-emitting glasses, which convert images into pulses of light printed onto the retina. A 58-year-old blind man was able to partially restore vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy. The patient, who lives in France, was diagnosed with retinitis pigmentosa (RP), a degenerative eye disease that affects the retina at the back of the eye and causes it to stop working, almost 40 years ago. year. However, several months after the treatment, he was able to recognize, count, locate and touch various objects with the treated eye while wearing a pair of light-stimulating glasses. The researchers say that although their findings, published in the journal Nature Medicine, are still in the early stages, their work could be seen as a stepping stone to targeted treatments. New target for people with RP (RP – a condition in which cells in the retina that receive light are disrupted, which can lead to total blindness). It is the most common inherited eye condition, affecting around 1 in 4,000 people in the UK. The researchers used a technique, called photogenetics, to genetically alter cells in the retina so that they produce light-sensitive proteins called channelrhodopsin. The treatment, which is done by injecting an eye into one eye, activates the gene that codes for a channelrhodopsin protein called ChrimsonR, which senses amber light. The team also developed specialized goggles equipped with a camera to capture and project visual images onto the retina at amber wavelengths of light. The patient then trained for several months as the genetically engineered cells began to stabilize. Seven months later, the patient began to show signs of improvement in vision, the researchers said. The team also said their patients were “excited” after this first experience of partial vision. With the aid of the light-stimulating glasses, the patient was able to locate, recognize, touch and count objects such as notebooks, pin boxes and glasses on a white table in front of him. The researchers also read the patients’ brain activity using a technique known as an electroencephalogram. A tortoise is alternately raised or removed from the table, and the patient must press a button to indicate whether it is there or not. The results from the experiments show that patients can recognize with 78% accuracy. Although this type of optical genetic therapy may be beneficial in restoring visual function in people with RP-related blindness, more results from this trial are needed, the researchers say. clearer picture of the safety and effectiveness of this approach. José-Alain Sahel, lead author of the study from France’s Sorbonne University and the National Center for Scientific Research, said: “It is important that blind patients suffer from various types of neurodegenerative diseases. and functional optic nerve would likely qualify for treatment. However, the effectiveness of the treatment depends on the extent of the patient’s optic nerve degeneration. He said it will take more time to study this method before it can be put into practice. Quynh Hoa According to The Irish Times

Yogurt is very good for health. Photo: Internet. Yogurt is ideal if you want a late-night snack. Yogurt is an excellent source of calcium, which is known for keeping your bones strong, helping you sleep better. Eating yogurt at night can help reduce hunger the next morning. If yogurt is your snack of choice, choose plain and pair it with unsweetened fruit. Pistachios Pistachios stand out among other nuts due to their high sleep-promoting melatonin content. Although all plant foods are said to naturally contain this substance, few have as much as pistachios. Strawberry Strawberries are very healthy without a lot of calories. This fruit is an excellent source of vitamin C and contains a notable amount of melatonin. Cherry Some studies show that cherries can help you sleep better. What’s more, they have anti-inflammatory benefits and may protect against inflammation-related conditions like arthritis and heart disease. In a recent study, a small group of older women with insomnia drank 240ml of pure cherry juice with breakfast and 1-2 hours before bedtime. After two weeks, these people slept almost 1.5 hours more at night. Sweet potato Steamed or boiled sweet potatoes contain a small amount of starch but are rich in amino acids, calcium, zinc and other vitamins. This food has a good support in the process of weight loss and helps skin elasticity better. Eating 1 boiled sweet potato every night helps the body lose 5-7kg/month without losing too much energy. Note: Try to have dinner or a snack two to three hours before bed. Avoid fatty foods to stay healthy. Truc Chi (th)

– Salted tomato ingredients: 1 kg eggplant, 2 garlic bulbs, 1/2 galangal root, about 10 chili peppers, chili sauce, white sugar, vinegar, fine salt, rice water. – Steps to perform: + Buy the eggplant to pick up the stalk, cut it in half or three and soak it in salt water so it doesn’t darken, after about 20 minutes, take it out and continue to put it in water to wash the rice and soak it for another 2-3 hours. The process of soaking in salt water and water to wash the rice so that the eggplant will both release plastic, not blacken, and release toxins available in the fruit. + Preliminary preparation of other ingredients: galangal peeled, washed, half cut only half, then cut into small pieces and then crushed with peeled garlic and chili. If you don’t have a blender, you can finely chop them as small as possible. Pay attention to the amount of chili peppers added, so just eat, don’t make it too spicy, it will lose the taste of the pickled tomato dish. + Prepare the brine: Add 1/2 bowl of white sugar rice, 1 bowl of chili sauce rice, 3-4 tablespoons of white vinegar, 1 tablespoon of table salt, 3 tablespoons of boiled white water to cool, and mix well until smooth. sugar and salt dissolved. Taste is good, but you need to remember to add more sweet and sour taste to salt and eat. Pour the previously ground chili, galangal, and garlic mixture into the mix, seeing that this brine is a bit thick, not too thin or too thick. + Put the eggplant in a bowl of salted water, mix well and let it sit for about 5 minutes. Then turn it again and put it in the refrigerator, after half a day it is ready to eat. The finished product is pickled curry Crispy, eye-catching color, with enough sweet and sour taste of sugar, vinegar and very characteristic aroma of garlic and galangal. This dish is also very delicious with crab soup or white rice, which is a favorite dish from children to adults. has the effect of stimulating digestion, helping to eat more delicious, supplementing microorganisms for the digestive system and a large amount of fiber to help avoid diseases such as constipation, hemorrhoids … Invite readers to watch the video “Chaosing the tray of 1 million dishes with only a few dishes, not including rice and sticky rice”. Source: VTV TSTC. However, eggplant also contains a toxin solanin, which is available in tubers and legumes. If not cooked, this amount of solanin is even higher, so salted eggplant, especially with a short salting time, is even more advised not to eat too much. So, when salting, to be safer, you absolutely do not skip the steps of soaking the tomatoes as above to ensure less toxins in the eggplant. Besides, pregnant women, people with a history of heart disease, kidney disease, liver disease, gastritis are also advised not to eat salted eggplant.

Recently, the team upgraded the technique to power and program the multipoint biostimulator from a single transmitter. Thanks to new research, electrical and computer engineer Kaiyuan Yang and colleagues at the George R. Brown School of Engineering (Rice University) won an award at the Society of Electrical and Electrical Engineers’ Custom Integrated Circuits Conference death (IEEE). The researchers performed experiments showing that an alternating magnetic field can be controlled by a battery-powered generator outside the body. The transmitter can be mounted on a belt or harness, powering and programming two or more implants at least 60 millimeters away. The implant can be programmed with a delay measured in microseconds. That could allow them to coordinate the activation of multiple wireless pacemakers in individual heart chambers, says engineer Yang. “Our study shows that it is possible to program the implants to stimulate in a coordinated pattern. We sync every device, like a symphony. That gives us a lot of scope in stimulant treatments, whether it’s for the heart rhythm or the spinal cord.” The scientists also experimented using small implants. Each tissue is about the size and weight of a vitamin. Experiments performed on hydra vulgaris rodents have demonstrated that, for at least a short distance, such devices can stimulate two separate hydras to contract. Then, activate a fluorescent tag to respond to electrical signals and respond at controlled amplitudes along the rodent’s sciatic nerve. “A study on spinal cord regeneration showed that multipoint stimulation in a certain pattern helps restore the nervous system. Several clinical studies are underway, but all are using desktop devices. There is no implantable tool that can do this,” said engineer Yang. Lab devices, called MagNI (for electromagnetic nerve implantation). MagNI was introduced early last year as a cordless spinal cord stimulator for power and programming. That means the wire does not need to be passed through the patient’s skin. Because, putting the wire through the skin is a method that can cause infection.

The new initiative aims to attract tourists to revitalize the Maldives economy, which largely depends on tourism. (Source: MTN) Maldives is an archipelagic country in South Asia, famous for its tropical climate and pristine waters, and depends heavily on tourism. About 67% of the country’s gross domestic product (GDP) is sourced directly and indirectly from the tourism industry. Currently, visitors to the Maldives must provide a negative PCR test for Covid-19 and proof of hotel reservation in order to be admitted. Maldives Tourism Minister Abdulla Mausoom recently said that the Maldives Health Protection Agency is about to announce the lifting of the entry restrictions for tourists who have completed the vaccination. In addition, the country is preparing to implement the 3V strategy – “Visit, Vaccinate, Vacation” to attract and facilitate international tourists. However, the Maldives has not decided on the time of implementing this program. The government will give priority to the people first and foremost, ensuring that all are vaccinated with 2 doses of Covid-19 vaccine. When that process is completed, the country will be ready to vaccinate foreign visitors to visit and travel. To date, 53% of the island nation’s approximately 530,000 residents have received the first shot of the Covid-19 vaccine, which includes 90% of frontline travel workers. It is not clear if tourists will have to pay for the vaccine, but the leader said vaccine supplies should not be an issue for the Maldives. The island nation receives vaccine funding from India, China and the World Health Organization (WHO) COVAX program; In addition, they also ordered more vaccines from Singapore. This year, the Maldives has welcomed 350,000 visitors, mainly visitors from neighboring country India. In addition, a large number of visitors come here under the “workation” model, with longer stays to work remotely. Minister Mausoom said these long-stay guests will also receive two doses of the vaccine. The target for the whole year 2021 of the Maldives is to welcome 1.5 million visitors and 10 million hotel nights. (according to VOV / CNBC)

Along with a series of promotions, the stimulus package also includes many attractive tourist activities such as: Show “Dance on the clouds”, Festival of flowers and brocade in Sa Pa, Festival of Culture and Tourism Sa Pa in Hanoi, Carnaval itinerary to connect Lao Cai tourism with Ninh Binh – Hue – Da Nang – Hoi An, experience sports tourism in Bac Ha, experience culture and cuisine of Ha Nhi people (Bat Xat), Spiritual tour of Thuong Temple – Bao Ha Temple – Fansipan … Show “Dance in the clouds”. According to Mr. Ha Van Thang, Director of the Department of Culture – Sports and Tourism of Lao Cai province, the goal of stimulating demand is to restore the key economic sector of the locality to the influence of the Covid-19 epidemic, but the final destination is The same is a safe, friendly Lao Cai with quality services, not just the number of customers. “Lao Cai province does not expect to reach 5 million or more than 5 million visitors. We set a goal in this complicated Covid-19 situation, how to ensure the safety of visitors, to bring to the best products and maintain the tourism products of Lao Cai. Glad that Lao Cai is currently ranked 4th in the 15 most attractive destinations of Vietnam as recently announced by the Tourism Council “- Mr. Ha Van Thang said. Previously, in 2020, Lao Cai also held two major tourism stimulus campaigns in May and October, contributing to an increase of 150% in the number of tourists coming to the locality, helping many businesses and businesses to have was able to recover from the heavy losses caused by the Covid-19 epidemic. On this occasion, as soon as the stimulus package was released, many positive signals were received. Particularly, the rate of booking for the next 30/4 – 1/5 holidays has reached 100 %./.

The journey “According to the history – The silent footprints – Saigon Villa” will help young people learn the heroic stories of the nation’s history. At the same time, on this journey, young people also visit the places marked by the soldiers of the Saigon Rangers. Itinerary “According to history – Silent Footprints – Saigon Cave” took place in one day. Coming to this tour, young people will learn about the history of Saigon in the 1965-1975 period, explore the old Saigon cuisine, take pictures with the Saigon scenes in the 1960s – 1970s. Young people can even receive souvenirs for themselves. Young people visit the Saigon Villa Coffee Shop (Photo: Lam Giang) Specifically, the tour “According to history – Silent Footprints – Saigon Rangers” will take young people to visit the relics: Secret mailboxes – Floating cellars – Weapon vaults of Saigon Rangers; visit the Saigon Villa Museum – the first private smart museum of the city. HCM City. Here, young people can also chat with “historical witnesses”. In addition, when participating in this tour, young people can watch short films about the intelligence route and enjoy dishes associated with soldiers such as Korean broken rice or butter coffee with sauces. porridge quẩy. For young people interested in spiritual tourism on this occasion, there will be a tour “Back to the sacred place” when coming to Binh Chanh district, where the ancient pagoda of Bat Buu Phat Da is located. This is a temple with bold primitive and ancient features among the green eucalyptus forests, is one of the places of religious and belief activities that attracts a large number of people to come to Buddha, visit … In addition, Binh Chanh also has a incense making village with the age of nearly 100 years, located along the roads in Le Minh Xuan commune. Closer and more realistic, young culinary lovers can explore a lively Saigon in every experience from street food of all regions and the world; from the melodramatic music in the tea room, the youthful music on the acoustic stage to the performance of the opera art, the warm family show of the ethnic artists … In which, two stories were chosen to tell. This occasion is “Exchange with typical families of three generations in Ho Chi Minh City” – the family of Meritorious Artist Tuyet Mai, with three generations of studying bamboo flute performance; and enjoy the Art of Poetry Singing at Ta Quan Le Van Duyet’s Mausoleum (at 9am every Sunday).

Ms. Tran Thi Phuong Lan, Acting Director of Hanoi Department of Industry and Trade speaking at the conference. Photo: Phuong Anh / VNA Speaking at the Conference, Ms. Tran Thi Phuong Lan, Acting Director of Hanoi Department of Industry and Trade, said that during the Hanoi centralized promotion program, participating businesses are allowed to carry out the program. promotion, customer gratitude with promotion up to 100%. The program is expected to be a lever to stimulate consumption after the impact of the COVID-19 epidemic, creating conditions for a large number of people in the capital to access and purchase tens of thousands of products with deep discounts and quality. guaranteed across the city. Thereby, contributing to the domestic market development goal is associated with the campaign “Vietnamese people give priority to using Vietnamese goods”, promoting production and business, stabilizing prices, stabilizing the market, curb inflation, ensure social security in the capital area. According to Mr. Nguyen Bach Tung, representative of the Organizing Committee of the Program, this second year, Hanoi has implemented the centralized promotion program of Hanoi city. In 2020, the program has brought encouraging results with the revenue of businesses participating in the event increasing from 100% – 200%, the number of other visitors to visit and shopping increased from 200% – 315% compared to normal days. With the results achieved by the program, it contributes to economic development, boost consumption, and perform the dual task of preventing the COVID-19 epidemic and ensuring economic development. Representative of BigC Long Bien Trade Center said that the unit participated in the program and achieved unexpected results. Especially the program “HaNoi Midnight sale without sleep” has attracted a large number of customers to shop, the unit is also very passive, so it has not prepared enough goods to serve the shopping needs of people. This year, the unit continues to register to participate in the program and wants the Organizing Committee to promote the program earlier so that people know and the unit also prepares goods to better serve consumers. This year, the opening ceremony of the program will be held at 8:00 p.m. on April 29 at King Ly Thai To Monument Square, Hoan Kiem District and officially launch demand stimulus, discount and promotion activities focusing on the months. 5, 7 and November. The program has the participation of 30 promotional centers gathering together with 2,000 promotional points throughout Hanoi city. Besides, there will be a series of attractive stimulus events. Accordingly, expected from April 29, 2021 – May 1, 2021, the “Nha Xinh for you” stimulus event at the sidewalk of Dinh Tien Hoang street, Hoan Kiem district with the scale of 25-30 display booths. , promote and stimulate demand in the fields of construction, furniture, home decoration, real estate. Hanoi summer shopping tourism stimulus festival 2021 at 30-50 major tourist and shopping destinations in the area. The launching ceremony of the program is expected to be held on May 21, 2021 and there will be a tourist stimulating booth, summer shopping taking place in 03 days 21-23 at Times City Square / Royal City with the participation of tourism businesses, transportation, airlines, supermarkets, commercial centers … for consumers to experience shopping and promotion. In order to stimulate the promotion and consumption of products of the Program One commune per commune (OCOP) and also the highlight of 2021, Hanoi organized the 2021 Hanoi traditional product stimulus month, the theme “Hanoi. past and present “at about 50-100 business points of participating businesses in the area. The launching ceremony of the program is expected to be held on July 10 and there will be a booth to stimulate tourism, summer shopping taking place in 3 days from 10 to 12/7 at Bat Trang craft village with the participation of businessmen. organizations, individuals trading traditional products, craft villages, OCOP … In November 2021, the Department of Industry and Trade of Hanoi coordinated with the Center for Investment Promotion, Trade and Tourism, to implement the program of the Hanoi Promotion Month in 2021 and the special stimulus and promotion programs on the last occasion. The year includes the opening ceremony of the Promotional Month Hanoi year 2021 on October 29, 2021; the opening ceremony of the “Cash Free Day” event; event “Tourism Promotion Day” in 3 days October 29 – October 31, 2021 …

Therefore, the short and thin eyelashes are always the worry of the sisters. Currently, there are many artificial ways to make eyelashes longer, such as mascara, false lashes, or eyelash extensions, but they are harmful by making real lashes weaker.

There are 3 types of foods: green vegetables, green tea, fresh milk – these are the “super foods” that help your eyelashes grow faster and bring you beautiful, attractive eyes.

1. Drink green tea to lengthen your eyelashes

Green tea is the food that helps you own curled eyelashes.

Green tea is the daily drink of every Vietnamese family. Drinking green tea is not only good for health, keeping your mind alert, but also has the effect of lengthening eyelashes faster thanks to the flavonoid content.

How to use green tea to lengthen eyelashes: Take a cotton ball dipped in thick green tea and dab it evenly on the eyelashes, the flavonoids will absorb and stimulate the growth of hair follicles, making eyelashes grow thicker and longer.

2. Green vegetables to help lengthen lashes

Green leafy vegetables provide a lot of health benefits for skin, hair and eyelashes. Green vegetables contain proteins, minerals, vitamins and other nutrients that benefit hair growth and make hair look healthy and beautiful, increasing the growth and thickness of hair, eyelashes, and eyebrows.

3. Fresh milk also helps to lengthen eyelashes

Regularly drinking fresh milk is a safe way to lengthen your eyelashes.

Fresh milk helps to stimulate the eyelashes to grow faster, thicker thanks to the proteins and vitamins in fresh milk that provide nourishment for the eyelashes. Fresh milk also helps to grow thicker, darker eyebrows.

How to use fresh milk to lengthen eyelashes: Prepare a bowl of fresh milk and a few cotton balls, then dip the cotton ball into the bowl of milk, then rub on the eyelashes and note that every day should drink milk to increase nutrients for lashes to grow.

The role of collagen in the skin

Collagen is a fibrous protein that accounts for about 30% of the protein in the body, accounting for 70% of the skin structure. The collagen fibers are long and thin, intertwined, creating a collagen network. The collagen network is the foundation of the skin. Collagen plays a role in connecting skin cells, stimulating the metabolism of skin cells, creating elasticity, firmness for the skin, and healing wounds. Therefore, collagen is the main ingredient that helps firm, smooth skin, is the deciding factor for the beauty of the skin. In the skin, collagen is most concentrated in the dermis.

As collagen is deficient due to degradation over time, the collagen fibers under the skin degrade in both quantity and quality, and the skin faces an unrestrained decline. Because at this time, the skin’s frame is weakened, the resistance is poor, wrinkles appear, the skin is sagging, the folds and sagging are worse.

Collagen depletion is a natural process in the body. After the age of 25, the amount of collagen in the body is reduced in two trends:

Quantity reduction: Every year, the amount of collagen decreases by 1%. By the age of 30, the amount of collagen is significantly deficient. This causes the amount of collagen to decrease gradually, the collagen network structure becomes loose and weak. The skin begins to show signs old.

Loss of quality: Due to the degeneration of collagen fibers over time: Being stretched, flaky and broken makes the skin no longer able to maintain firmness, elasticity, and smoothness. Skin becomes dull, dry. Collagen reduction in each year is calculated as follows: After age 25: Skin has a shortage of collagen 1.5%; after the age of 30, there is a 15% shortage of collagen; After age 40, there is a lack of 30% of collagen and 45% of the amount of collagen after the age of 50.

Stress, stress reduces the natural collagen production.

What factors reduce collagen?

Age: Typically, collagen production begins to decline by about 1% per year, from the moment you begin your late teenage years. Depending on the person, this phase can start sooner or later.

Damage by UV rays: Many studies show that up to 90% of skin aging is caused by the sun and only 10% due to factors inside the body. The sun’s UV rays can damage the skin, depleting the collagen in the skin. UV exposure can damage collagen through a variety of mechanisms, including damaging the DNA of collagen-producing cells, as well as promoting the production of free radicals that directly affect collagen. collagen in the skin.

Smoking: Smoking cigarettes can cause many negative health effects, including accelerating premature aging. Smoking cigarettes can reduce the amount of oxygen reaching tissues, making them unable to regenerate, becoming damaged and dying. This can lead to premature wrinkle formation.

Inflammatory diet: Inflammation is one of the main “enemies” of tissues in the body, including collagen-derived connective tissue. Inflammatory diet is a diet high in sugar, simple carbohydrates, processed foods … that can stimulate the immune system, promote inflammation in the body. In particular, the high sugar content in the body causes collagen in the skin to harden, break open, weaken the skin, promote premature aging.

Stress, stress, insomnia: Excessive stress can trigger inflammation, reducing the body’s ability to naturally produce collagen. Stress also increases the hormone cortisol, which in turn contributes to reducing collagen production nature.

Genetics: Genetics is an important factor that can determine how much collagen the body breaks down and rebuilds. Therefore, if your grandparents, your parents keep beautiful, youthful skin for a long time, it is very likely that you will also inherit this.

How to supplement collagen? Skin Care

Facial massage: This is a simple yet effective way. Every day you perform a facial massage for about 10-15 minutes can stimulate collagen production and enhance blood circulation,

Use moisturizers for the skin: Natural home masks such as aloe vera mask, honey mask and egg yolk can be used to keep skin clean, firm and soft.

Lifestyle changes

Quit smoking and eat less sugar.

Protect your skin from the effects of UV rays: When on the street, you should use a hat, sunglasses, a mask, and a sunscreen to protect your skin, use sunscreen even when it is not sunny.

Enhance physical exercise to exercise sports: Exercise facilitates blood circulation, more deeply, brightens skin, radiant and even color. Regular exercise will help slow down the aging process as it promotes collagen production.

When the skin is full, collagen will become firm and youthful.

Recover collagen with food

Choose foods rich in vitamin C: Natural collagen supplement with fruits such as oranges, lemons, blueberries, and grapefruit provide your body with a plentiful amount of vitamin C. This is considered to be a powerful antioxidant that both removes harmful free radicals, stimulates the body to produce collagen, maintains skin elasticity and prevents skin aging. effective skin. Vitamin C is a key ingredient in the formation of collagen. If the body lacks vitamin C, the amino acids cannot connect to make collagen.

Dark green vegetables help replenish collagen: Dark green vegetables such as spinach, cabbage, asparagus, broccoli … contain many vitamins, minerals and antioxidants that help prevent Harmful free radicals, improve the skin’s resistance and stimulate the body to increase collagen production effectively.

Red fruits and vegetables: These foods are rich in the antioxidant active ingredient lycopene. This substance both acts as a natural sunscreen and helps stimulate the body to increase collagen production effectively. Therefore, you should increase your intake of red vegetables such as bell peppers, tomatoes, strawberries, carrots, berries, watermelon …

In addition, avocado, cowpea, soybeans, garlic … are very effective collagen recovery foods.