Biotech company Oxitec released its genetically modified mosquitoes in the Florida Keys, with the goal of stopping wild populations of disease-carrying mosquitoes in the area. This is the first time genetically modified mosquitoes have been released in the US.
Genetically modified mosquito larvae will be released in the US. Oxitec has previously released the aegypti Aedes mosquito in Brazil, the Cayman Islands, Panama and Malaysia, and the company has reported that the local strain of A. aegypti has reduced by at least 90%. A. aegypti can carry diseases such as Zika, dengue, chikungunya and yellow fever, and the release of genetically modified mosquitoes is one way to control this population without the use of insecticides. Oxitec’s genetically engineered mosquitoes are male, engineered to carry lethal genes; When genetically modified pests mate with wild female mosquitoes, the lethal gene is passed on to their offspring. Although the gene does not affect the survival of males, it prevents females from building an essential protein and thus causes them to die before adulthood. Only female mosquitoes bite humans (male mosquitoes only drink nectar), so denatured mosquitoes and their surviving males cannot transmit disease to humans. A. aegypti mosquitoes make up about 4% of all mosquitoes in the Florida Keys but cause the majority of mosquito-borne diseases in the area. The region typically spends $1 million a year on mosquito control, resorting to costly measures such as aerial spraying. Release of hundreds of millions of genetically modified mosquitoes could be a less expensive and more effective option, especially as mosquito populations become resistant to pesticides over time. Oxitec was approached by the local government in 2010, and after a decade of regulatory review and local feedback, both the board and the U.S. Environmental Protection Agency finally approved the plan. Release of genetically modified mosquitoes in the Keys. At the end of April, the company placed boxes of mosquito eggs at six locations in Cudjoe Key, Ramrod Key and Vaca Key, according to Nature. Over the next 12 weeks, about 12,000 newly hatched male mosquitoes will emerge from the box. This will be an initial test so Oxitec can collect data before conducting a second test with nearly 20 million mosquitoes later this year. The company will capture mosquitoes during the test to see how far the insects travel from their boxes, how long they live, and whether female mosquitoes actually pick up the lethal gene and die. To make it easier to track genetically engineered mosquitoes, Oxitec introduced a gene that causes the mosquitoes to glow under a specific color of light. The experiment was met with strong opposition from a small portion of Florida Keys residents, as well as the Florida Keys Environmental Alliance and Food Safety Center. Concerned that the boxes of mosquito eggs could be vandalized, Oxitec placed them in a secret place and did not reveal their exact location to the public. Questions remain as to whether genetically modified mosquitoes cause undesirable effects on mosquitoes, local animals, or the ecosystem at large. For example, after Oxitec released genetically modified mosquitoes in Jacobina, Brazil, genes from the insect were mutilated in local mosquito populations, suggesting that the lethal gene failed to kill some females before they can mate. According to a 2019 study published in the journal Scientific Reports, their hybrids did not carry the lethal gene, but instead carried genes from the original Cuban and Mexican mosquito populations used to create the modified mosquitoes. genes. It is unclear whether these new genes may have changed the biology of the mosquito. Molecular biologist Natalie Kofler, founder of E Edit Nature, an organization that advocates for the responsible use of gene editing, told Nature she hopes the Oxitec test will be conducted in a transparent and in a way that might make some community members feel better about the whole situation.
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