Create super stem cells to overcome graft rejection

Potential multi-potential stem cells hold great promise in the field of regenerative medicine. Because they have the ability to reproduce indefinitely, as well as to develop into all other types of cells in the body such as nerves, heart, pancreas and liver, it can be considered as the only source of cells that can replace. For parts damaged or lost due to accident or illness …
The ability to regenerate any type of tissue

The team at Kyoto University Japan has created inducible pluripotent stem cells (iPS) that can overcome the immune system’s failure to accept transplanted cells in cell treatments. The research team is headed by lecturer Akitsu Hotta at the iPS Research and Application Center of Kyoto University. The team said they used gene editing to replace proteins on cell surfaces, which can cause the immune system to reject transplanted cells. According to the researchers, through animal testing and other means, they have confirmed that the iPS cells they generate reduce the risk of transplant rejection. IPS cells can be used to create cells that can regenerate any type of tissue in the body. Their method is able to generate 7 types of iPS cells and is applicable to more than 95% of the Japanese population. Previously, researchers at Keio University – Japan submitted a proposal to the Government for a clinical trial using iPS stem cells to treat patients with spinal cord injuries. Each year, about 5,000 people are said to lose the ability to move their limbs due to spinal cord injuries, the disease currently has no effective treatment. IPS cells can be used to create replacement cells for any tissue in the body. The team’s goal is to transplant cells into the patient so that these cells develop into nerve cells that transmit signals from the brain to restore the ability of the patient to move arms and legs. Japanese researchers have also made significant strides in their efforts to seek treatment for Parkinson’s disease (fibrillation paralysis). According to the group of researchers, for the first time in the world they have successfully transplanted iPS stem cells into the patient’s brain. “We did the transplant for the first time. The patient is recovering well now ”. GS. Ryosuke Takahashi at Kyoto University said. They performed this groundbreaking surgery recently, which implanted 2.4 million iPS cells into the brain of a 50-year-old male patient. The purpose of this procedure is to prevent Parkinson’s disease from causing depleted neurons. business. The research team will follow the patient for about 2 years to evaluate the safety and effectiveness of this method. Not stopping there, the above research group has developed iPS into the precursor cells of the reproductive cells. These cells were then cultured for about 3 months, in the same box as the oocytes isolated from the pups. The team claims to have obtained spherical cells with large cell nuclei. After analyzing the shape and characteristics of these cells, the team concluded that these are oocytes, the precursors of oocytes. The team says the work will help develop techniques for making human eggs from induction pluripotent stem cells. They can explain the cause of infertility through research on egg formation. Stem cells can develop into every other type of cell in the body. Breakthroughs … The pioneer in this technology is the laboratory of GS. Shinya Yamanaka at Kyoto University, Japan. In 2006, he published four genes with specially coded transcription factors that help transform from adult cells to multipotential stem cells. Together with Professor John Gurdon, he was awarded the 2012 Nobel Prize in Biomedical Sciences for “discoveries of adult cells that have the ability to be reprogrammed to become multi-potential stem cells”. Previous studies have concerned that reprogramming adult cells into iPS poses major risks, making the method limited in humans. For example, if a virus is used to alter the genotype in a cell, some oncogene expression genes are likely to be activated. However, scientists have announced the invention of a technology that helps to remove cancer-causing genes after multi-potential induction, making the application of iPS in the treatment of human diseases become more feasible. time is over. Currently, iPS cells are opening up a promising research direction in the treatment of genetic diseases in humans such as Down or polycystic kidney disease. In addition, iPS cells from impaired patients, which are not observed in iPS cells from healthy people, also provide additional physiological insights into these diseases. Nguyen Hung ( (Theo japantimes, nature) )