Flipping the lab virus leaks

Viruses that cause smallpox, anthrax, and influenza have escaped research facilities, and sometimes with deadly consequences.

Researchers wear protective gear at the Wuhan Institute of Virology. Photo: Xinhua US President Joe Biden announced last week that the US intelligence community had questioned two possible origins of the COVID-19 pandemic: “Human contact with infected animals or a laboratory incident. “. He ordered a new investigation “to bring us closer to a final conclusion”. According to Bloomberg, no matter where the investigation leads, the history of laboratory safety shows that leakage of pathogens has happened, sometimes with deadly consequences. Smallpox virus leak By the late 1970s, smallpox had been eradicated from the wild, but research on the disease continues in several laboratories around the world, including one in Birmingham (UK). where a virulent strain of smallpox virus is handled. In the summer of 1978, a medical photographer working there named Janet Parker became ill. When pustules spread on her body, the local doctor diagnosed it as a severe case of smallpox. Victim Janet Parker in the smallpox virus leak from the laboratory. It was the third leak of the smallpox virus in that decade from a UK laboratory. The British government has drastically stopped the outbreak by urgently isolating hundreds of people and vaccinating many others. Thanks to those efforts, only one other person became infected, and that was Parker’s mother. However, the female photographer experienced a painful, lonely death in quarantine, and is believed to be the last known fatal victim of smallpox. But there are other victims of the incident. At that time the press mentioned the director of the laboratory in Birmingham, a smallpox virus expert named Henry Bedson. Although there was no evidence, the media still blamed him for the incident. Quarantined at home and in despair, Bedson slit his own throat and died shortly thereafter. The British government has organized a thorough investigation into the outbreak. An investigation found Mr Bedson may not have followed adequate safety procedures and speculated that Parker contracted smallpox from a virus that leaked into the gas pipeline. Technicians at a laboratory in Rockville, Maryland (USA), where smallpox vaccine is produced. A lawsuit later dismissed this explanation, and raised the disturbing possibility that Parker herself had entered one of the workspaces without proper protection. To this day, the debate over the Parker incident remains unresolved. Anthrax spores from the lab When laboratories let pathogens leak in a secret environment, it is much harder to confirm the source of the outbreak. A case in point is the anthrax outbreak in Sverdlovsk, a rather isolated city in the former Soviet Union. In 1979, rumors of anthrax killing dozens, even thousands, began to spread to the West. Later that year, Soviet newspapers confirmed some reports, noting that more than 100 people had contracted anthrax after eating contaminated meat, and over 60 had died. It was a tragedy, but perhaps unavoidable because anthrax is readily apparent in local animal populations. However, US intelligence officials are not convinced by that. Satellite images show disinfecting truck-like objects around the city, with a significant focus of activity on a mysterious military facility known as Complex 19. CIA analysts have reported hypothesized that the Soviet Union leaked a weaponized form of anthrax. The Soviets reacted indignantly to this allegation. In 1980, Russia’s official news agency Itar Tass published a rebuttal titled “A Seed of Deception,” accusing the US of making false statements to gain geopolitical advantage. Sverdlovsk was once one of the military secret cities of the Soviet era. Then, under the administration of President Ronald Reagan, the CIA sought to better handle what happened. They asked Matthew Meselson, a distinguished geneticist at Harvard who worked on the bioweapons ban program, to directly assess the evidence. Mr. Meselson was not convinced by the US intelligence findings. In the 1980s, he rejected another theory that the Soviet Union used some kind of fungal weapon in Laos – and he initially held the same view on the anthrax case, endorsing the main explanation. information from the Soviet Union, with one important caveat: Without a thorough investigation in Sverdlovsk, it would be impossible to know for certain what happened. Essentially, Mr. Meselson supported the explanation that the meat was tainted, judging it to be “completely reasonable and consistent” based on what was known about anthrax. He also arranged meetings with Soviet scientists to add credence to this interpretation, with slides of pathology samples taken from the victims. The US intelligence community, however, remains skeptical. And in this case, the intelligence agencies, not the scientists, turned out to be right. After the breakup of the Soviet Union, Meselson and other researchers finally had access to pathological samples taken from the victims’ lungs, which showed they had died from inhaling anthrax spores. Subsequent revelations added to the picture of what happened. Turns out Complex 19 is a biological weapons facility. Here they produce anthrax spores. According to the Laboratory Director of Complex 19 at the time, a filter connected to the spore dryer was clogged. This still happens often. The military officer in charge left a message for his replacement on the next shift but did not enter the logbook as is customary. When it came to the next shift, the replacement team looked at the notebook, saw nothing, and restarted the purifier. A series of anthrax spores quickly spread throughout the vicinity. Mr. Meselson eventually pieced together all the data and published a paper in the journal Science, which combined wind data with interviews, pathological samples and other evidence to describe the outbreak. Coal killed more than 60 people. That was in 1994, 15 years after the incident. Mysterious flu virus leak In addition, there is another incident that took place in the Soviet Union that is still a mystery. In the same decade that witnessed the leaks of smallpox in Britain and anthrax in the Soviet Union, there was also an unusual strain of flu at the time, called H1N1. Laboratory virus leaks have had deadly consequences. Photo: Atlantis In 1977, an H1N1 outbreak broke out on the border between China and the Soviet Union. The epidemic eventually spread worldwide that year, causing an unusual proportion of young patients. The mortality rate from epidemics is relatively low compared to some strains of influenza. But that’s not the problem. The worrying aspect of the epidemic is that this particular strain of H1N1 has not been present since 1950, when it was superseded by other strains of influenza. The appearance of that kind of “back in time” was confusing. Some researchers speculate that the virus may have “escaped” from a laboratory in the Soviet Union or China, but both countries deny this theory. However, the matter remains a puzzle for virologists. Many theories have been born and come to explain the so-called “frozen evolution”, among which the most prominent is the hypothesis that the virus spread to humans from a laboratory, possibly testing a vaccine to neutralize the disease. swine flu. A scientist involved in the development of a vaccine. Photo: Reuters The exact origin of COVID-19 may not be known All of the above incidents occurred in the 1970s. Laboratory safety was expected to have improved since then, but that has not always been the case. After the SARS outbreak in 2003, laboratories around the world began studying the virus. Since that time, there have been no less than 6 laboratory leaks of SARS. The first occurred at the National University of Singapore, where a student contracted the virus from a sample of the virus. This was followed by an incident in Taiwan/China, where a researcher contracted the virus, possibly during the disinfection of waste products from the laboratory. After that, several leaks happened at the National Institute of Virology of China. In one incident, a researcher infected her mother with the virus, and she died of SARS. In all cases, human negligence, mainly exacerbated by inadequate safety protocols, was the cause of the pathogen leakage. History has supported the theories being put forward that the current COVID-19 pandemic may not have a natural origin, but we are not in a position to rush into judgment. When it comes to lab leaks, the investigation and review process often takes a long time, and sometimes the answers remain unsatisfactory and incomplete. In the case of the COVID pandemic, we must prepare for the possibility that the world may never know the exact origins of a pandemic that has claimed millions of lives.