In the course of taking the drug, the drug can cause kidney toxicity, disrupt kidney function, affect other organs, and even be dangerous. Therefore, those who have, are suffering from kidney disease, especially kidney failure should be very cautious when using the drug.
The kidneys are the main organ for drug excretion, so the renal parenchyma is very sensitive to the drug. Drugs can cause kidney damage by the following mechanisms: Reduced renal perfusion, direct toxicity to renal tubular cells, renal interstitial damage, renal vascular obstruction, tubular obstruction, and manifestations of acute and chronic renal failure.
The liver and kidney are two organs that excrete drugs, some drugs are eliminated mainly through the liver, others are eliminated mainly by the kidneys. Therefore, when kidney disease, kidney function is impaired, the use of drugs in people with kidney disease has 3 risks, that is, nephrotoxic drugs that decrease kidney function worse.
Second, the drug is eliminated slowly and will accumulate in the body, causing an increased effect.
Third, causing homeostasis due to renal failure, thereby susceptible to drug toxicity even at the appropriate dose.
Some drugs are toxic to the kidneys
With a healthy kidney, when suffering from a certain disease, drugs must be used, the kidneys will be cleaned normally, but for people with kidney disease, especially kidney failure (all kidney functions have been impaired) when Taking certain medications puts you at risk of further kidney damage.
Some drugs can be toxic to the kidneys, especially long-term use, high doses and especially self-medicating for self-healing not under the prescription of the doctor. For example, some antibiotics of the amynoglycoside group (streptomycin, gentamycin, amikacin …), quinolone group (ciprofloxacin, ofloxacin …), vancomycin group, cyclin group, cephalosporin group 1, 2 or antifungal (amphotericin B, ketoconazole …) or Vietnamese, Oriental medicine of unknown origin; Contrast drug used for X-ray with high permeability or some cancer treatment chemicals (cisplatin, methotrexate …).
People with kidney damage should pay attention when using the drug.
In addition, some drugs are not directly toxic to the kidneys but cause kidney anemia, reducing glomerular filtration rate or if used long term will cause renal entity failure. For example, antihypertensive drugs, when used in overdose cause hypotension cause renal anemia and impaired glomerular filtration, especially the class of ACE inhibitors and angiotensin II receptor antagonists. Nonsteroidal anti-inflammatory drugs (indomethacin, diclofenac …), inhibiting prostaglandin synthesis are factors that cause vasodilation leading to kidney anemia.
Note when using drugs in people with kidney problems
We all know, drugs (Western medicine or Vietnamese medicine, Oriental medicine) all have a curative effect and all drugs that are put into the body pass through the kidneys and are filtered here. Therefore, when suffering from kidney disease, especially kidney failure, it is very important to check the function of the kidneys (that is, follow the test order of the doctor) before using the drug to know and know. the exact state of kidney disease, glomerular filtration rate and kidney function must be checked during drug use, especially when taking long-term medication.
Comply with the instructions and instructions when taking drugs of the doctor to avoid adversely affecting the kidneys.
Do not buy, take drugs by yourself or do not change the dosage by yourself or change the drug without consulting your doctor to avoid harming the kidneys due to improper use of the drug.
In addition, drink enough water every day to facilitate drug purification (there are drugs when used need to drink a lot of water to help the kidneys purify drugs better).
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